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NANOTER

Development of Ultra-Sensitive Nanotherapeutic Anticancer Agents for Boron Neutron CaptureTherapy

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "NANOTER" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

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 Project objective

One of the major challenges in modern society is the early diagnosis and treatment of diseases. Cancer is one of the most relevant diseases worldwide because of its incidence, prevalence and mortality. Current cancer treatments do not only kill cancer cells but also healthy tissue. In order to overcome this situation, more effective and selective treatments are necessary. Neutron capture therapy (NCT) is a biologically targeted form of radiotherapy which exploits the potential of some specific isotopes to capture thermal neutrons producing charged particles suitable for the treatment of cancer. The range of the particles produced in NCT can be limited to the size of one cell. Therefore, provided that neutron capture species are selectively delivered to tumour cells, no damage will occur to the surrounding healthy tissue. Novel delivery agents suitable for NCT must be investigated that will allow a localised cancer treatment. NANOTER presents an innovative and previously unexplored approach to develop ultra-sensitive nanotherapeutic agents for NCT. Neutron capture species will be sealed in the interior of carbon nanocapsules (biocompatible closed-ended carbon nanotubes) and their behaviour against neutron irradiation experiments will be investigated and compared against other current materials for NCT. The interdisciplinary approach taken to develop the proposed research programme is expected to contribute to the development of alternative and previously unexplored nanoplatforms for NCT, enhancing the performance of current delivery agents for NCT.

 Publications

year authors and title journal last update
List of publications.
2018 Carla I. M. Santos, Inês F. A. Mariz, Sandra N. Pinto, Gil Gonçalves, Igor Bdikin, Paula A. A. P. Marques, Maria Graça P. M. S. Neves, José M. G. Martinho, Ermelinda M. S. Maçôas
Selective two-photon absorption in carbon dots: a piece of the photoluminescence emission puzzle
published pages: 12505-12514, ISSN: 2040-3364, DOI: 10.1039/C8NR03365J
Nanoscale 10/26 2019-06-13
2018 Concepcion Domingo, Alejandro Borrás-Caballero, Gil Gonçalves, Gregorio Marbán, Stefania Sandoval, Susana Pinto, Paula Marques, Julio Fraile, Gerard Tobias, Ana López-Periago
Preparation and characterization of graphene oxide aerogels: exploring the limits of supercritical CO2 fabrication methods
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201803368
Chemistry - A European Journal 2019-06-13
2018 Magdalena Kierkowicz, Elzbieta Pach, Ana Santidrián, Stefania Sandoval, Gil Gonçalves, Ester Tobías-Rossell, Martin Kalbáč, Belén Ballesteros, Gerard Tobias
Comparative study of shortening and cutting strategies of single-walled and multi-walled carbon nanotubes assessed by scanning electron microscopy
published pages: 922-932, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2018.06.021
Carbon 139 2019-06-13

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