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Conversion of natural plant nanovesicles into nutraceutical delivery system

Total Cost €


EC-Contrib. €






 nanoTOM project word cloud

Explore the words cloud of the nanoTOM project. It provides you a very rough idea of what is the project "nanoTOM" about.

surrounded    release    biology    populations    vesicles    membrane    characterization    biological    regarding    considerable    training    poorly    options    molecular    pipeline    vehicles    absorbed    bioactive    host    enhancement    biogenesis    have    transfer    biocargo    pharmaceutical    lack    active    expertise    omics    uniquely    protection    outreach    morphologically    food    of    cellular    secret    tomato    plant    create    concerted    events    bioavailability    vesicle    mechanism    nanovesicle    phospholipid    background    biosciences    drive    team    nanovesicles    strategy    compounds    extracellular    nanotom    researcher    expand    industrialization    bioresources    context    analytical    secretion    alternative    heterogeneity    edible    ibbr    architecture    nutraceutical    difficult    hampered    profiling    lycopersicum    cells    mammalian    interdisciplinary    chemist    medicinal    isolation    herbal    solanum    academic    ingredients    group    toxicological    encapsulation    novel    composition    nutraceuticals    plants    realize   

Project "nanoTOM" data sheet

The following table provides information about the project.


Organization address
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Novel encapsulation approaches to create alternative delivery options for nutraceuticals are emerging as a promising strategy to enhance the bioavailability of poorly absorbed active food ingredients. In this context, nanoTOM aims to exploit edible plant derived nanovesicles and use them as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. Plant cells secret phospholipid membrane-surrounded vesicles morphologically similar to mammalian extracellular vesicles. Exploitation of plant nanovesicles is promising although hampered by i) their difficult isolation and ii) the lack of knowledge of their biogenesis, molecular architecture, uptake and biological effects. The experienced researcher is a chemist with strong academic and pharmaceutical background in the isolation and analysis of bioactive compounds from medicinal plants who team-up with the Institute of Biosciences and BioResources (IBBR) with considerable expertise in extracellular vesicle research to realize a uniquely interdisciplinary research program. The research proposed here will realize the following concrete objectives: 1. Set-up an integrated analytical pipeline for the isolation, characterization, encapsulation, uptake and toxicological profiling of plant nanovesicles. 2. Use the pipeline to exploit different Solanum lycopersicum (tomato) nanovesicle populations regarding secretion mechanism, heterogeneity, biocargo composition, nutraceutical and encapsulation properties. Neither of these objectives have been addressed before and both have high potential to expand the knowledge in the field and to drive the research activity towards industrialization. The research objectives are integrated with concerted training objectives in plant, cellular and molecular biology and omics, outreach program, dissemination events and considerable knowledge transfer in the isolation and use of herbal nutraceuticals from the researcher to the IBBR host group.

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The information about "NANOTOM" are provided by the European Opendata Portal: CORDIS opendata.

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