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Conversion of natural plant nanovesicles into nutraceutical delivery system

Total Cost €


EC-Contrib. €






 nanoTOM project word cloud

Explore the words cloud of the nanoTOM project. It provides you a very rough idea of what is the project "nanoTOM" about.

industrialization    host    realize    characterization    plants    events    edible    difficult    release    ibbr    expand    novel    nutraceutical    vesicle    create    absorbed    secret    transfer    biology    heterogeneity    profiling    hampered    solanum    lack    nanotom    enhancement    analytical    training    vehicles    chemist    extracellular    cellular    considerable    plant    alternative    have    concerted    bioavailability    surrounded    biocargo    bioactive    interdisciplinary    compounds    biogenesis    outreach    architecture    cells    uniquely    poorly    omics    vesicles    food    phospholipid    pharmaceutical    encapsulation    protection    active    mammalian    membrane    mechanism    researcher    ingredients    nanovesicles    options    morphologically    drive    nanovesicle    group    pipeline    herbal    nutraceuticals    tomato    populations    regarding    medicinal    academic    toxicological    strategy    context    composition    expertise    lycopersicum    biosciences    biological    molecular    team    of    background    bioresources    secretion    isolation   

Project "nanoTOM" data sheet

The following table provides information about the project.


Organization address
city: ROMA
postcode: 185

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Novel encapsulation approaches to create alternative delivery options for nutraceuticals are emerging as a promising strategy to enhance the bioavailability of poorly absorbed active food ingredients. In this context, nanoTOM aims to exploit edible plant derived nanovesicles and use them as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. Plant cells secret phospholipid membrane-surrounded vesicles morphologically similar to mammalian extracellular vesicles. Exploitation of plant nanovesicles is promising although hampered by i) their difficult isolation and ii) the lack of knowledge of their biogenesis, molecular architecture, uptake and biological effects. The experienced researcher is a chemist with strong academic and pharmaceutical background in the isolation and analysis of bioactive compounds from medicinal plants who team-up with the Institute of Biosciences and BioResources (IBBR) with considerable expertise in extracellular vesicle research to realize a uniquely interdisciplinary research program. The research proposed here will realize the following concrete objectives: 1. Set-up an integrated analytical pipeline for the isolation, characterization, encapsulation, uptake and toxicological profiling of plant nanovesicles. 2. Use the pipeline to exploit different Solanum lycopersicum (tomato) nanovesicle populations regarding secretion mechanism, heterogeneity, biocargo composition, nutraceutical and encapsulation properties. Neither of these objectives have been addressed before and both have high potential to expand the knowledge in the field and to drive the research activity towards industrialization. The research objectives are integrated with concerted training objectives in plant, cellular and molecular biology and omics, outreach program, dissemination events and considerable knowledge transfer in the isolation and use of herbal nutraceuticals from the researcher to the IBBR host group.

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The information about "NANOTOM" are provided by the European Opendata Portal: CORDIS opendata.

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