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ToxoPersist SIGNED

Molecular Basis of Toxoplasma gondii Encystation and Persistence

Total Cost €


EC-Contrib. €






 ToxoPersist project word cloud

Explore the words cloud of the ToxoPersist project. It provides you a very rough idea of what is the project "ToxoPersist" about.

responsible    fast    intracellular    infection    vivo    versatilities    mass    power    sensitivity    bottlenecks    manifestations    animals    replicating    pvm    initiates    membrane    parasitism    governing    trafficking    host    form    anticipate    residence    technologies    nervous    parasite    reactivation    parasitophorous    transmission    discoveries    network    permanent    infecting    genome    slow    capitalize    vacuole    fundamental    crispr    imaging    muscles    adaption    onset    maldi    editing    initiate    parasites    microscopy    biological    toxoplasma    govern    cellular    successful    maturation    despite    resolution    components    barrier    heart    spectrometry    immune    rudimentary    life    wall    metabolic    nanosims    cyst    immunosuppression    pv    warm    regulatory    hosts    ex    molecular    cas9    pmv    strategies    circuits    severe    obligate    tachyzoites    persistence    poses    defies    unbiased    gondii    mechanisms    subversion    encystation    cw    bradyzoites    tissue    ultimately    convert    striated    clinical    effectors    central    encephalitis    blooded    ensures    omics    functions    cysts    pathogenesis    threat    virtually    intervention    immunocompetent    examination   

Project "ToxoPersist" data sheet

The following table provides information about the project.


Organization address
city: GENEVE
postcode: 1211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 2˙297˙606 €
 EC max contribution 2˙297˙606 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 2˙297˙606.00


 Project objective

Toxoplasma gondii is the most successful obligate intracellular parasites infecting virtually all warm-blooded animals. A infection initiates with the dissemination of the fast-replicating tachyzoites. At the onset of the immune response tachyzoites convert into slow-growing bradyzoites that form cysts in the central nervous system and in striated and heart muscles. Encystation ensures life-long persistence and poses a significant threat of reactivation during immunosuppression and can lead to encephalitis and severe clinical manifestations. Despite the importance of encystation for pathogenesis and transmission, our insight into how T. gondii defies the immune responses to take up permanent residence in the immunocompetent hosts is rudimentary. We propose to determine the molecular mechanisms governing cyst wall formation and parasite adaption to encystation. We will capitalize on the increased sensitivity of -omics approaches, the power of the CRISPR/Cas9 genome editing, the high-resolution microscopy, and on the ex-vivo tissue examination by MALDI imaging mass spectrometry and NanoSIMS technologies.The specific objectives are to: 1. Identify the components of the Cyst Wall (CW), Parasitophorous Vacuole (PV) and PMV Membrane (PVM) of the cyst 2. Determine the parasite factors responsible for CW formation and maturation via targeted and unbiased approaches 3. Define the metabolic network of parasite that is able to initiate encystation and ensure persistence 4. Measure subversion of host metabolic functions by parasite effectors during encystation and persistence We anticipate fundamental discoveries on i) the regulatory and trafficking circuits that govern CW formation as a biological barrier during encystation ii) metabolic adaptation and subversion of host cellular functions during encystation. Ultimately, understanding parasite strategies and versatilities that ensures its parasitism in immunocompetent hosts and bottlenecks as new targets for intervention.


year authors and title journal last update
List of publications.
2019 Gaëlle Lentini, David J. Dubois, Bohumil Maco, Dominique Soldati‐Favre, Karine Frénal
The roles of Centrin 2 and Dynein Light Chain 8a in apical secretory organelles discharge of Toxoplasma gondii
published pages: , ISSN: 1398-9219, DOI: 10.1111/tra.12673
Traffic 2019-09-02
2018 Pierre-Mehdi Hammoudi, Bohumil Maco, Sunil Kumar Dogga, Karine Frénal, Dominique Soldati-Favre
Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis
published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.13981
Molecular Microbiology 2019-06-13
2017 Pierre-Mehdi Hammoudi, Dominique Soldati-Favre
Insights into the molecular basis of host behaviour manipulation by Toxoplasma gondii infection
published pages: 563-572, ISSN: 2397-8554, DOI: 10.1042/ETLS20170108
Emerging Topics in Life Sciences 1/6 2019-06-13
2018 Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet
Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06733-w
Nature Communications 9/1 2019-06-06
2017 Karine Frénal, Damien Jacot, Pierre-Mehdi Hammoudi, Arnault Graindorge, Bohumil Maco, Dominique Soldati-Favre
Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii
published pages: 15710, ISSN: 2041-1723, DOI: 10.1038/ncomms15710
Nature Communications 8 2019-06-06

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