Explore the words cloud of the ToxoPersist project. It provides you a very rough idea of what is the project "ToxoPersist" about.
The following table provides information about the project.
UNIVERSITE DE GENEVE
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙297˙606 €|
|EC max contribution||2˙297˙606 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
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|1||UNIVERSITE DE GENEVE||CH (GENEVE)||coordinator||2˙297˙606.00|
Toxoplasma gondii is the most successful obligate intracellular parasites infecting virtually all warm-blooded animals. A infection initiates with the dissemination of the fast-replicating tachyzoites. At the onset of the immune response tachyzoites convert into slow-growing bradyzoites that form cysts in the central nervous system and in striated and heart muscles. Encystation ensures life-long persistence and poses a significant threat of reactivation during immunosuppression and can lead to encephalitis and severe clinical manifestations. Despite the importance of encystation for pathogenesis and transmission, our insight into how T. gondii defies the immune responses to take up permanent residence in the immunocompetent hosts is rudimentary. We propose to determine the molecular mechanisms governing cyst wall formation and parasite adaption to encystation. We will capitalize on the increased sensitivity of -omics approaches, the power of the CRISPR/Cas9 genome editing, the high-resolution microscopy, and on the ex-vivo tissue examination by MALDI imaging mass spectrometry and NanoSIMS technologies.The specific objectives are to: 1. Identify the components of the Cyst Wall (CW), Parasitophorous Vacuole (PV) and PMV Membrane (PVM) of the cyst 2. Determine the parasite factors responsible for CW formation and maturation via targeted and unbiased approaches 3. Define the metabolic network of parasite that is able to initiate encystation and ensure persistence 4. Measure subversion of host metabolic functions by parasite effectors during encystation and persistence We anticipate fundamental discoveries on i) the regulatory and trafficking circuits that govern CW formation as a biological barrier during encystation ii) metabolic adaptation and subversion of host cellular functions during encystation. Ultimately, understanding parasite strategies and versatilities that ensures its parasitism in immunocompetent hosts and bottlenecks as new targets for intervention.
|year||authors and title||journal||last update|
GaÃ«lle Lentini, David J. Dubois, Bohumil Maco, Dominique Soldatiâ€Favre, Karine FrÃ©nal
The roles of Centrin 2 and Dynein Light Chain 8a in apical secretory organelles discharge of Toxoplasma gondii
published pages: , ISSN: 1398-9219, DOI: 10.1111/tra.12673
Pierre-Mehdi Hammoudi, Bohumil Maco, Sunil Kumar Dogga, Karine FrÃ©nal, Dominique Soldati-Favre
Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis
published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.13981
Pierre-Mehdi Hammoudi, Dominique Soldati-Favre
Insights into the molecular basis of host behaviour manipulation by Toxoplasma gondii infection
published pages: 563-572, ISSN: 2397-8554, DOI: 10.1042/ETLS20170108
|Emerging Topics in Life Sciences 1/6||2019-06-13|
Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M. Walker, Zenon A. Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A. Baker, Oliver Billker, Mathieu Brochet
Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06733-w
|Nature Communications 9/1||2019-06-06|
Karine FrÃ©nal, Damien Jacot, Pierre-Mehdi Hammoudi, Arnault Graindorge, Bohumil Maco, Dominique Soldati-Favre
Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii
published pages: 15710, ISSN: 2041-1723, DOI: 10.1038/ncomms15710
|Nature Communications 8||2019-06-06|
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