Explore the words cloud of the SYNTOMAGX project. It provides you a very rough idea of what is the project "SYNTOMAGX" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||2˙291˙875 €|
|EC max contribution||2˙291˙875 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||UNIVERSITAT BAYREUTH||DE (BAYREUTH)||coordinator||2˙291˙875.00|
An immensely valuable asset to the field of synthetic biology would be a means to genetically endow magnetism to living organisms, which is still an unsolved challenge due to the lack of appropriate tools. In contrast, biomagnetism is innate to magnetotactic bacteria, mud-dwelling microbes which as geomagnetic sensors biomineralize iron nanocrystals with exceptional properties, the magnetosomes. However, transplantation of magnetosome biosynthesis has remained unachieved for many years, owing to its complexity and lack of knowledge of genetic determinants. Recently, my lab discovered relevant biosynthetic gene clusters and for the first time succeeded in expressing them in a foreign bacterium. Inspired by this major breakthrough, I now propose a step change approach for endogenous magnetization of diverse organisms based on bacterial magnetosome biosynthesis. By combining systematic genetic reduction with bottom-up redesign we will first minimize the pathway to make it universally portable. We will then reprogram E. coli into a chassis for plug-in expression of diverse magnetosome gene sets. By harnessing determinants of structurally diverse magnetosomes from various bacteria, we will reconfigure the pathway for mix-and-match generation of designer nanoparticles with tuned magnetic properties. Finally, we will attempt to reconstitute key parts of magnetosome formation in eukaryotic hosts by using yeast mitochondria as a universal model. The overall aim is to generate a versatile synthetic toolkit for genetic magnetization of different organisms. This would represent a quantum leap with tremendous impact on various fields of biomedical research and biotechnology. It might be exploited for bioproduction of tailored magnetic nanomaterials with novel and tunable properties. It could be further utilized to generate intracellular labels, tracers and actuators for magnetic manipulation and analysis of cells and organisms in the emerging field of magnetogenetics.
|year||authors and title||journal||last update|
Frank Mickoleit, Dirk SchÃ¼ler
Generation of nanomagnetic biocomposites by genetic engineering of bacterial magnetosomes
published pages: 86-98, ISSN: 2045-9858, DOI: 10.1680/jbibn.18.00005
|Bioinspired, Biomimetic and Nanobiomaterials 8/1||2020-02-27|
Frank Mickoleit, Dirk SchÃ¼ler
Generation of Multifunctional Magnetic Nanoparticles with Amplified Catalytic Activities by Genetic Expression of Enzyme Arrays on Bacterial Magnetosomes
published pages: 1700109, ISSN: 2366-7478, DOI: 10.1002/adbi.201700109
|Advanced Biosystems 2/1||2020-02-27|
Frank Mickoleit, Christian B. Borkner, Mauricio Toro-Nahuelpan, Heike M. Herold, Denis S. Maier, JÃ¼rgen M. Plitzko, Thomas Scheibel, Dirk SchÃ¼ler
In Vivo Coating of Bacterial Magnetic Nanoparticles by Magnetosome Expression of Spider Silk-Inspired Peptides
published pages: 962-972, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01749
RenÃ© Uebe, Noa Keren-Khadmy, Natalie Zeytuni, Emanuel Katzmann, Yotam Navon, Geula Davidov, Ronit Bitton, JÃ¼rgen M. Plitzko, Dirk SchÃ¼ler, Raz Zarivach
The dual role of MamB in magnetosome membrane assembly and magnetite biomineralization
published pages: 542-557, ISSN: 0950-382X, DOI: 10.1111/mmi.13899
|Molecular Microbiology 107/4||2020-02-27|
Oliver Raschdorf, Florian Bonn, Natalie Zeytuni, Raz Zarivach, DÃ¶rte Becher, Dirk SchÃ¼ler
A quantitative assessment of the membrane-integral sub-proteome of a bacterial magnetic organelle
published pages: 89-99, ISSN: 1874-3919, DOI: 10.1016/j.jprot.2017.10.007
|Journal of Proteomics 172||2020-02-27|
Daniel Pfeiffer, Mauricio Toro-Nahuelpan, Marc Bramkamp, JÃ¼rgen M. Plitzko, Dirk SchÃ¼ler
The Polar Organizing Protein PopZ Is Fundamental for Proper Cell Division and Segregation of Cellular Content in Magnetospirillum gryphiswaldense
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.02716-18
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