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ILC_REACTIVITY SIGNED

Biological Determinants of ILC Reactivity for Immune Responses in Health and Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 ILC_REACTIVITY project word cloud

Explore the words cloud of the ILC_REACTIVITY project. It provides you a very rough idea of what is the project "ILC_REACTIVITY" about.

innovative    mouse    responsiveness    immediately    ongoing    combination    helper    dependent    active    datasets    intervention    human    implications    17a    biology    pathogen    transcriptional    light    immunological    hematopoietic    activation    individuals    receptors    family    gamma    th17    lymphoid    interleukin    ilc2    il    life    tissues    adult    collectively    adaptive    immune    single    shed    amounts    nk    activated    healthy    defense    humans    natural    parasitic    effector    cutting    promptly    checkpoints    vivo    thereby    viral    cells    ilcs    lack    prerequisite    first    ilc3    regulate    function    digital    cytokines    fetal    groups    nevertheless    th2    newly    tnf    previously    ctl    threshold    unclear    tissue    infections    harnessing    reactivity    prior    ilc1    models    play    clinical    alpha    killer    line    circulating    mucosal    share    determinants    ilc    immunity    biological    report    22    antigen    edge    homeostasis    diverse    bacterial    cell    roles    innate    normal    technologies    critical    functional    interferon    complementary    computational    disease    mice    13   

Project "ILC_REACTIVITY" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/fr/team/innate-immunity/
 Total cost 1˙899˙375 €
 EC max contribution 1˙899˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙899˙375.00

Map

 Project objective

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α and interferon-γ) and thereby contribute to the immediate, first-line immune defense against viral, bacterial, and parasitic infections. ILCs include the previously described natural killer (NK) cells and have a similar 'natural' effector function which is immediately available during immune responses and prior to that of adaptive immunity. Three groups of ILC (ILC1, ILC2, ILC3) have been described that share biological activities of T helper (Th)1, Th2 and Th17/22 subsets and CTL. ILCs are active during both fetal and adult life and play important roles in the homeostasis of mucosal and non-mucosal tissues. Nevertheless, how ILCs are integrated into ongoing immune responses remains unclear and this knowledge is a prerequisite for harnessing the clinical potential of these immune effector cells. This proposal will investigate critical checkpoints that can regulate ILC reactivity for immune responses in humans and mice. The four proposed objectives will be addressed using a combination of cutting-edge technologies including innovative mouse models that can report on ILC biology in vivo, single cell transcriptional and functional analysis of diverse circulating and tissue human and mouse ILC subsets, ‘digital’ pathogen-dependent ILC activation approaches and computational analysis of large immunological datasets from healthy, normal human individuals. Collectively, these complementary studies will shed new light on the biological determinants which condition ILC reactivity in humans and mice. Understanding how the threshold of ILC responsiveness is set prior to and during immune responses will have important implications for disease intervention.

 Publications

year authors and title journal last update
List of publications.
2018 Pedro M. Rodrigues, Ana R. Ribeiro, Nicolas Serafini, Catarina Meireles, James P. Di Santo, Nuno L. Alves
Intrathymic Deletion of IL-7 Reveals a Contribution of the Bone Marrow to Thymic Rebound Induced by Androgen Blockade
published pages: 1389-1398, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701112
The Journal of Immunology 200/4 2019-06-13
2018 Pedro Gonçalves, João Ricardo Araújo, James P Di Santo
A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease
published pages: 558-572, ISSN: 1078-0998, DOI: 10.1093/ibd/izx029
Inflammatory Bowel Diseases 24/3 2019-06-13
2019 Wei Xu, Dylan E. Cherrier, Sylvestre Chea, Christian Vosshenrich, Nicolas Serafini, Maxime Petit, Pentao Liu, Rachel Golub, James P. Di Santo
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials
published pages: , ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.02.022
Immunity 2019-05-22
2018 Dylan E. Cherrier, Nicolas Serafini, James P. Di Santo
Innate Lymphoid Cell Development: A T Cell Perspective
published pages: 1091-1103, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.05.010
Immunity 48/6 2019-04-18
2018 Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, Gérard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N.J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits
Innate Lymphoid Cells: 10 Years On
published pages: 1054-1066, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.07.017
Cell 174/5 2019-04-18

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