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MATRICAN SIGNED

Matrix during cancer progression

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MATRICAN project word cloud

Explore the words cloud of the MATRICAN project. It provides you a very rough idea of what is the project "MATRICAN" about.

alterations    drive    leaving    orthotopic    transgenic    primary    patients    imaging    organs    mouse    proteomics    ms    situ    components    interactions    pancreatic    structure    validate    mice    lab    subsequent    stiffness    quantitative    validation    responsible    regulates    composition    normal    pathological    upregulated    combat    human    metastasis    evolution    spatio    perturbation    play    bearing    3d    biochemical    cancer    progression    scaffolds    structural    cells    intact    driving    spectrometry    stages    breast    fibrillogenesis    tissue    functional    repopulated    disease    models    deaths    strategies    mapping    decrease    tumours    live    impacts    tumour    erc    90    decellularise    matrix    critical    clinic    global    ecm    extracellular    fundamental    patient    metastatic    marked    ground    proteins    repopulation    cellular    structurally    samples    translated    relevance    mass    breaking    discovered    lines    benefit    cell    lack   

Project "MATRICAN" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://erlerlab.com/matrican/
 Total cost 1˙997˙500 €
 EC max contribution 1˙997˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙997˙500.00

Map

 Project objective

The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer patient deaths. In order to do this, my lab has developed a method to in situ decellularise organs leaving structurally intact ECM scaffolds for subsequent analysis or for repopulation to study cell-ECM interactions in situ. We have deployed our method to decellularise primary tumour and metastatic organs in mice bearing orthotopic breast cancer tumours for subsequent quantitative global mass spectrometry (MS) proteomics, spatio-structural mapping of ECM components in 3D, and live imaging of repopulated cells. We observed fundamental alterations in ECM composition and structure between normal and tumour, and primary and metastatic tissue. We have selected two ECM components specifically upregulated in metastatic organs for subsequent validation. We discovered a marked decrease in proteins associated with fibrillogenesis in metastatic organs and will investigate the impact of this on metastatic ECM stiffness. We will decellularise organs from transgenic mouse models of breast and pancreatic cancer, at specific stages during cancer progression to determine the evolution of global ECM composition and structure, and how this impacts on cell behaviour through functional perturbation. Finally, we shall validate relevance of findings to human disease through use of human cancer lines and analysis of human patient samples. The research proposed will provide ground-breaking insight into how the ECM regulates cellular behaviour during normal and pathological conditions, and will test new strategies to combat metastasis that could be translated into the clinic to benefit cancer patients.

 Publications

year authors and title journal last update
List of publications.
2019 Alejandro E Mayorca-Guiliani, Oliver Willacy, Chris D. Madsen, Maria Rafaeva, Stefanie Elisabeth Heumüller, Felix Bock, Gerhard Sengle, Manuel Koch, Thomas Imhof, Frank Zaucke, Raimund Wagener, Takako Sasaki, Janine T. Erler, Raphael Reuten
Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D
published pages: , ISSN: 1754-2189, DOI: 10.1038/s41596-019-0225-8
Nature Protocols 2019-11-14
2019 Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar
Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments
published pages: e201900304, ISSN: 2575-1077, DOI: 10.26508/lsa.201900304
Life Science Alliance 2/3 2019-08-06

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