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FluoroDendriNostic

Combined fluorinated polymer and poly-L-lysine dendrimer as new potential contrast agents for magnetic resonance imaging 19F

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 FluoroDendriNostic project word cloud

Explore the words cloud of the FluoroDendriNostic project. It provides you a very rough idea of what is the project "FluoroDendriNostic" about.

regular    functionalization    materials    drug    expertise    polymers    blocks    ultimate    good    structure    magnetic    variety    copolymer    host    afford    micelles    vivo    series    vitro    assembly    purely    signature    suitable    amphiphiles    poly    of    fluorinated    biosynthetic    technique    cancer    team    fundamental    supramolecular    created    early    compounds    synthesize    cylinders    techniques    self    noise    polymerization    diagnosis    diseases    19f    fluoropolymers    amphiphilic    immunogenic    signal    nanoreactors    biocompatible    spectroscopic    alternative    organization    researcher    dendrimer    imaging    agents    resonance    combining    ratio    arborescent    molecular    fluoropolymer    attractive    dendrigrafts    solvent    bearing    phenomena    morphologies    tumors    mri    hydrophobic    polymer    destructive    originally    lysine    hydrogenated    invasive    powerful    vesicles    dgls    copolymers    contrast    dendritic    platform    biomedical    aggregates    nanoparticles    complementary    shown    coatings    structures   

Project "FluoroDendriNostic" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.oreillygrouplab.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 38˙219.00
2    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 145˙235.00

Map

 Project objective

Early diagnosis of diseases, including tumors, is the ultimate goal of biomedical imaging. Magnetic resonance imaging (MRI) is a technique for non-destructive and non-invasive diagnosis of a number of diseases including cancer. Recently, contrast agents bearing 19F have been introduced as an attractive alternative to purely hydrogenated compounds, because of their high signal to noise ratio as result of their unique spectroscopic signature. This project aims to design, synthesize and characterize a series of novel fluorinated amphiphilic structures based on a fluoropolymer and a dendrimer (so called DendriGrafts, DGLs) based on poly-L-lysine. DGLs are a new type of arborescent biosynthetic polymer of regular and controlled structure. They have been shown to be biocompatible and non-immunogenic. It proposed that these DGLs to have potential as a powerful platform for the functionalization of hydrophobic polymers and to afford fluoropolymers for applications in 19F MRI. Combining DGLs and fluoropolymers in a good solvent for one of the blocks, is proposed to enable self-assembly of the amphiphiles into a variety of morphologies and molecular aggregates (including micelles, vesicles or cylinders). Increasing attention has been given to this type of supramolecular organization and to their potential use in applications such as coatings, drug delivery systems, nanoparticles or nanoreactors. Thus, this project will not only study the fundamental phenomena of self-organization of these novel copolymers but will also result in new materials suitable for application as novel agents in 19F MRI. Combining the complementary expertise from the Experienced Researcher in dendritic polymers, the host team in polymerization techniques and polymer self-assembly, a series of novel copolymer systems will be originally created in this project and finally studied by in vitro and in vivo.

 Publications

year authors and title journal last update
List of publications.
2019 Couturaud Benoit; Panagiotis G. Georgiou; Spyridon Varlas; Joseph R. Jones; Maria C. Arno; Jeffrey C. Foster; Rachel K. O\'Reilly
Poly(Pentafluorophenyl Methacrylate)-Based Nano-Objects Developed by Photo-PISA as Scaffolds for Post-Polymerization Functionalization
published pages: , ISSN: , DOI: 10.5281/zenodo.2545669 		2019-05-25
2018 Jeffrey C. Foster; Spyridon Varlas; Benoit Couturaud; Joseph R. Jones; Robert Keogh; Robert T. Mathers; Rachel K. O\'Reilly
Predicting Monomers for Use in Polymerization-Induced Self-Assembly
published pages: , ISSN: , DOI: 10.5281/zenodo.2545666 		2019-05-25

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