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FluoroDendriNostic

Combined fluorinated polymer and poly-L-lysine dendrimer as new potential contrast agents for magnetic resonance imaging 19F

Total Cost €

0

EC-Contrib. €

0

Partnership

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 FluoroDendriNostic project word cloud

Explore the words cloud of the FluoroDendriNostic project. It provides you a very rough idea of what is the project "FluoroDendriNostic" about.

self    resonance    early    compounds    cancer    mri    molecular    alternative    techniques    fluoropolymer    bearing    spectroscopic    biocompatible    diagnosis    dendrimer    vitro    ultimate    phenomena    polymerization    regular    copolymers    biomedical    team    invasive    noise    arborescent    hydrogenated    fundamental    micelles    complementary    lysine    dgls    hydrophobic    good    materials    afford    nanoreactors    blocks    polymers    signal    researcher    fluoropolymers    contrast    assembly    suitable    tumors    supramolecular    shown    host    dendritic    polymer    functionalization    attractive    synthesize    technique    imaging    structures    aggregates    vesicles    platform    created    drug    powerful    cylinders    amphiphiles    19f    ratio    originally    vivo    combining    series    amphiphilic    purely    nanoparticles    of    dendrigrafts    organization    poly    fluorinated    coatings    magnetic    variety    solvent    structure    diseases    destructive    biosynthetic    immunogenic    agents    signature    expertise    copolymer    morphologies   

Project "FluoroDendriNostic" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.oreillygrouplab.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 38˙219.00
2    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 145˙235.00

Map

 Project objective

Early diagnosis of diseases, including tumors, is the ultimate goal of biomedical imaging. Magnetic resonance imaging (MRI) is a technique for non-destructive and non-invasive diagnosis of a number of diseases including cancer. Recently, contrast agents bearing 19F have been introduced as an attractive alternative to purely hydrogenated compounds, because of their high signal to noise ratio as result of their unique spectroscopic signature. This project aims to design, synthesize and characterize a series of novel fluorinated amphiphilic structures based on a fluoropolymer and a dendrimer (so called DendriGrafts, DGLs) based on poly-L-lysine. DGLs are a new type of arborescent biosynthetic polymer of regular and controlled structure. They have been shown to be biocompatible and non-immunogenic. It proposed that these DGLs to have potential as a powerful platform for the functionalization of hydrophobic polymers and to afford fluoropolymers for applications in 19F MRI. Combining DGLs and fluoropolymers in a good solvent for one of the blocks, is proposed to enable self-assembly of the amphiphiles into a variety of morphologies and molecular aggregates (including micelles, vesicles or cylinders). Increasing attention has been given to this type of supramolecular organization and to their potential use in applications such as coatings, drug delivery systems, nanoparticles or nanoreactors. Thus, this project will not only study the fundamental phenomena of self-organization of these novel copolymers but will also result in new materials suitable for application as novel agents in 19F MRI. Combining the complementary expertise from the Experienced Researcher in dendritic polymers, the host team in polymerization techniques and polymer self-assembly, a series of novel copolymer systems will be originally created in this project and finally studied by in vitro and in vivo.

 Publications

year authors and title journal last update
List of publications.
2019 Couturaud Benoit; Panagiotis G. Georgiou; Spyridon Varlas; Joseph R. Jones; Maria C. Arno; Jeffrey C. Foster; Rachel K. O\'Reilly
Poly(Pentafluorophenyl Methacrylate)-Based Nano-Objects Developed by Photo-PISA as Scaffolds for Post-Polymerization Functionalization
published pages: , ISSN: , DOI: 10.5281/zenodo.2545669
2019-05-25
2018 Jeffrey C. Foster; Spyridon Varlas; Benoit Couturaud; Joseph R. Jones; Robert Keogh; Robert T. Mathers; Rachel K. O\'Reilly
Predicting Monomers for Use in Polymerization-Induced Self-Assembly
published pages: , ISSN: , DOI: 10.5281/zenodo.2545666
2019-05-25

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