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transcriPTIon

Understanding transcriptional regulation in plant PAMP-triggered immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 transcriPTIon project word cloud

Explore the words cloud of the transcriPTIon project. It provides you a very rough idea of what is the project "transcriPTIon" about.

ideal    establishing    culminating    mentorship    immunoprecipitation    plasma    reprogramming    survival    constantly    strategies    heretofore    genes    networks    transcriptional    plants    plant    communication    thaliana    fragmented    mechanisms    yields    individual    international    cells    overexpressed    cohesive    immunity    agricultural    recognition    stress    lab    graduate    unknown    effect    techniques    vital    host    protein    identity    pamps    regulation    candidates    pamp    exploration    triggered    pattern    elucidate    acting    express    co    massive    generate    scientific    lines    transplanta    rna    signalling    immunoblotting    prepare    events    lack    independent    microbial    me    mediated    array    perceived    tfs    inducibly    regardless    immune    utilize    pathogens    mode    molecular    transcription    pathogen    defence    select    broadly    detection    adaptive    exposed    seq    chromatin    opportunity    patterns    biotechnological    receptors    membrane    pti    activate    initial    collection    crop    arabidopsis    protection    leader    prepared    sequencing   

Project "transcriPTIon" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.tsl.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-21   to  2018-09-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host lab and institution in new techniques, scientific communication, and international collaboration make this an ideal opportunity to prepare me for a future as an independent research leader.

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