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transcriPTIon

Understanding transcriptional regulation in plant PAMP-triggered immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 transcriPTIon project word cloud

Explore the words cloud of the transcriPTIon project. It provides you a very rough idea of what is the project "transcriPTIon" about.

plasma    adaptive    survival    ideal    reprogramming    yields    membrane    candidates    pathogens    defence    regardless    detection    pathogen    leader    prepare    mechanisms    exploration    graduate    cells    cohesive    immune    lines    networks    agricultural    mode    sequencing    effect    mediated    independent    acting    chromatin    immunoprecipitation    lab    express    me    stress    immunoblotting    co    recognition    triggered    perceived    transcriptional    massive    array    scientific    transcription    communication    rna    individual    protein    microbial    techniques    molecular    pti    plant    constantly    generate    regulation    establishing    patterns    identity    pattern    signalling    transplanta    protection    seq    thaliana    fragmented    arabidopsis    prepared    host    unknown    opportunity    culminating    overexpressed    heretofore    mentorship    crop    broadly    biotechnological    strategies    vital    international    lack    collection    pamps    genes    activate    plants    pamp    utilize    events    tfs    receptors    exposed    inducibly    immunity    initial    elucidate    select   

Project "transcriPTIon" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.tsl.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-21   to  2018-09-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

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 Project objective

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host lab and institution in new techniques, scientific communication, and international collaboration make this an ideal opportunity to prepare me for a future as an independent research leader.

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