Opendata, web and dolomites

ASYMMEM SIGNED

Lipid asymmetry: a cellular battery?

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ASYMMEM project word cloud

Explore the words cloud of the ASYMMEM project. It provides you a very rough idea of what is the project "ASYMMEM" about.

focussing    explaining    mostly    quantifying    thermodynamic    fundamental    dynamic    reconstitute    implies    chemical    quantify    steady    microscopy    employ    regulating    linked    pave    store    quasi    local    tools    asymmetric    display    trans    machinery    sciences    equilibrium    serves    area    textbook    clear    situation    fuel    existence    almost    events    removed    biological    force    organisms    mechanistic    bilayer    structures    photochemical    asymmetry    biosensors    least    light    components    analysing    intense    perturbations    consequently    continued    virtually    localized    membrane    ground    hub    plasma    rapid    cellular    model    fusion    justification    energy    maintained    ultimately    break    life    cell    membranes    unknown    genetic    it    lipid    outer    monitoring    movement    leaflets    notion    motility    probes    vitro    remodelling    kinetics    inner    dynamics    protein    fission    basic    instance    function    evolution    driving    signalling    regard    timescales    suited   

Project "ASYMMEM" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙500˙000.00

Map

 Project objective

It is a basic textbook notion that the plasma membranes of virtually all organisms display an asymmetric lipid distribution between inner and outer leaflets far removed from thermodynamic equilibrium. As a fundamental biological principle, lipid asymmetry has been linked to numerous cellular processes. However, a clear mechanistic justification for the continued existence of lipid asymmetry throughout evolution has yet to be established. We propose here that lipid asymmetry serves as a store of potential energy that is used to fuel energy-intense membrane remodelling and signalling events for instance during membrane fusion and fission. This implies that rapid, local changes of trans-membrane lipid distribution rather than a continuously maintained out-of-equilibrium situation are crucial for cellular function. Consequently, new methods for quantifying the kinetics of lipid trans-bilayer movement are required, as traditional approaches are mostly suited for analysing quasi-steady-state conditions. Addressing this need, we will develop and employ novel photochemical lipid probes and lipid biosensors to quantify localized trans-bilayer lipid movement. We will use these tools for identifying yet unknown protein components of the lipid asymmetry regulating machinery and analyse their function with regard to membrane dynamics and signalling in cell motility. Focussing on cell motility enables targeted chemical and genetic perturbations while monitoring lipid dynamics on timescales and in membrane structures that are well suited for light microscopy. Ultimately, we aim to reconstitute lipid asymmetry as a driving force for membrane remodelling in vitro. We expect that our work will break new ground in explaining one of the least understood features of the plasma membrane and pave the way for a new, dynamic membrane model. Since the plasma membrane serves as the major signalling hub, this will have impact in almost every area of the life sciences.

 Publications

year authors and title journal last update
List of publications.
2018 Nicolai Wagner, Milena Stephan, Doris Höglinger, André Nadler
A Click Cage: Organelle-Specific Uncaging of Lipid Messengers
published pages: 13339-13343, ISSN: 1433-7851, DOI: 10.1002/anie.201807497
Angewandte Chemie International Edition 57/40 2019-08-29
2017 Alf Honigmann, André Nadler
The Next Frontier: Quantitative Biochemistry in Living Cells
published pages: 47-55, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b01060
Biochemistry 57/1 2019-08-29
2019 Milena Schuhmacher, Andreas T. Grasskamp, Nicolai Wagner, Benoit Lomardot, Jan. S. Schuhmacher, Pia Sala, Annett Lohmann, Ian Henry, Andrej Shevchenko, Ünal Coskun, Alexander Walter, André Nadler
Adressing lipid structural diversity in signalling: Photochemcial probes for live-cell lipid biochemistry (reprint)
published pages: , ISSN: , DOI: 10.1101/711291
2019-08-29
2019 Nicolai Wagner, Milena Schuhmacher, Annett Lohmann, André Nadler
A coumarin triflate reagent enables one‐step synthesis of photo‐caged lipid metabolites for studying cell signaling
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201903909
Chemistry – A European Journal 2019-09-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASYMMEM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASYMMEM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Aware (2019)

Aiding Antibiotic Development with Deep Analysis of Resistance Evolution

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More  

CARBYNE (2020)

New carbon reactivity rules for molecular editing

Read More