Protoeukaryotes
Multicompartmental Designs For Protocells
Total Cost €
0EC-Contrib. €
0Partnership
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0Protoeukaryotes project word cloud
Explore the words cloud of the Protoeukaryotes project. It provides you a very rough idea of what is the project "Protoeukaryotes" about.
Project "Protoeukaryotes" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF BRISTOL
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2018-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF BRISTOL | UK (BRISTOL) | coordinator | 183˙454.00 |
Map
Project objective
Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis. No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary and cutting edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof.Stephen Mann FRS) has made tremendous progress in the last few years.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/C8CC01129J |
Chemical Communications 54/29 | 2019-05-10 |
| 2018 |
B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann Enzyme-powered motility in buoyant organoclay/DNA protocells published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3 |
Nature Chemistry 10/11 | 2019-05-10 |
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