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Protoeukaryotes

Multicompartmental Designs For Protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Protoeukaryotes project word cloud

Explore the words cloud of the Protoeukaryotes project. It provides you a very rough idea of what is the project "Protoeukaryotes" about.

metabolites    species    drug    exchange    kumar    quintessential    compartments    homeostasis    exists    compartmentalization    bristol    smart    leadership    apart    harvesting    artificial    tremendous    diagnosis    micromachines    complexity    environment    parallel    pavan    regulation    model    membranes    made    stephen    expertise    stimuli    university    broadened    structural    metabolite    membrane    organelles    sensing    exhibiting    chemical    self    perceived    clinical    ing    group    networks    interacting    function    bound    selective    mimics    protocell    feedback    few    disciplinary    frs    gates    interaction    detoxification    hosting    locomotion    organization    functions    protocellular    cells    programmed    living    multicompartmental    date    hierarchical    activate    enabled    replication    construction    prof    polymers    compartment    issue    remote    origin    light    last    responsive    mann    edge    cellular    regard    dr    levels    eukaryotic    life    perform    cutting    models    progress    constructing    minimal    nanochannels    literature    transport    protocells   

Project "Protoeukaryotes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis. No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary and cutting edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof.Stephen Mann FRS) has made tremendous progress in the last few years.

 Publications

year authors and title journal last update
List of publications.
2018 B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann
Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells
published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/C8CC01129J
Chemical Communications 54/29 2019-05-10
2018 B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann
Enzyme-powered motility in buoyant organoclay/DNA protocells
published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3
Nature Chemistry 10/11 2019-05-10

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