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Protoeukaryotes

Multicompartmental Designs For Protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Protoeukaryotes project word cloud

Explore the words cloud of the Protoeukaryotes project. It provides you a very rough idea of what is the project "Protoeukaryotes" about.

locomotion    protocells    perform    stephen    transport    drug    nanochannels    made    interaction    tremendous    regulation    smart    exists    last    issue    enabled    complexity    apart    membrane    interacting    prof    cells    literature    stimuli    compartment    structural    artificial    few    replication    models    living    edge    dr    model    selective    life    metabolite    broadened    detoxification    membranes    minimal    frs    parallel    leadership    mimics    responsive    polymers    mann    homeostasis    expertise    feedback    light    functions    chemical    organelles    protocellular    protocell    function    gates    hierarchical    constructing    programmed    cellular    university    group    progress    clinical    remote    disciplinary    eukaryotic    networks    kumar    bristol    origin    exhibiting    ing    date    organization    levels    construction    multicompartmental    environment    pavan    activate    diagnosis    perceived    exchange    hosting    regard    micromachines    sensing    cutting    self    compartmentalization    quintessential    compartments    bound    species    harvesting    metabolites   

Project "Protoeukaryotes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis. No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary and cutting edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof.Stephen Mann FRS) has made tremendous progress in the last few years.

 Publications

year authors and title journal last update
List of publications.
2018 B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann
Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells
published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/C8CC01129J
Chemical Communications 54/29 2019-05-10
2018 B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann
Enzyme-powered motility in buoyant organoclay/DNA protocells
published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3
Nature Chemistry 10/11 2019-05-10

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