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Protoeukaryotes

Multicompartmental Designs For Protocells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Protoeukaryotes project word cloud

Explore the words cloud of the Protoeukaryotes project. It provides you a very rough idea of what is the project "Protoeukaryotes" about.

progress    quintessential    group    origin    constructing    bound    compartmentalization    harvesting    mann    programmed    clinical    expertise    date    sensing    polymers    chemical    metabolite    construction    issue    diagnosis    replication    multicompartmental    kumar    environment    self    regulation    species    interacting    frs    micromachines    broadened    compartments    perceived    hierarchical    gates    function    membranes    activate    leadership    functions    locomotion    compartment    regard    prof    apart    organelles    cutting    university    transport    parallel    perform    dr    responsive    hosting    selective    drug    organization    remote    networks    cellular    stimuli    bristol    protocells    metabolites    homeostasis    protocellular    feedback    literature    model    detoxification    edge    exchange    eukaryotic    living    enabled    complexity    artificial    disciplinary    few    nanochannels    ing    protocell    made    pavan    mimics    interaction    life    exists    exhibiting    levels    smart    light    tremendous    minimal    models    structural    membrane    cells    stephen    last   

Project "Protoeukaryotes" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis. No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary and cutting edge field of protocells in which the hosting group at the University of Bristol (under the leadership of Prof.Stephen Mann FRS) has made tremendous progress in the last few years.

 Publications

year authors and title journal last update
List of publications.
2018 B. V. V. S. Pavan Kumar, James Fothergill, Joshua Bretherton, Liangfei Tian, Avinash J. Patil, Sean A. Davis, Stephen Mann
Chloroplast-containing coacervate micro-droplets as a step towards photosynthetically active membrane-free protocells
published pages: 3594-3597, ISSN: 1359-7345, DOI: 10.1039/C8CC01129J
Chemical Communications 54/29 2019-05-10
2018 B. V. V. S. Pavan Kumar, Avinash J. Patil, Stephen Mann
Enzyme-powered motility in buoyant organoclay/DNA protocells
published pages: 1154-1163, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0119-3
Nature Chemistry 10/11 2019-05-10

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