Explore the words cloud of the ES-Cat project. It provides you a very rough idea of what is the project "ES-Cat" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||3˙827˙031 €|
|EC max contribution||3˙827˙031 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-03-01 to 2021-02-28|
Take a look of project's partnership.
|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||273˙287.00|
|2||MEDIMMUNE LIMITED||UK (CAMBRIDGE)||participant||546˙575.00|
|3||RIJKSUNIVERSITEIT GRONINGEN||NL (GRONINGEN)||participant||510˙748.00|
|4||UNIVERSITE CATHOLIQUE DE LOUVAIN||BE (LOUVAIN LA NEUVE)||participant||501˙120.00|
|5||UNIVERSITAET GREIFSWALD||DE (GREIFSWALD)||participant||498˙432.00|
|6||WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER||DE (MUENSTER)||participant||498˙432.00|
|7||JOHNSON MATTHEY PLC||UK (LONDON)||participant||273˙287.00|
|8||BEN-GURION UNIVERSITY OF THE NEGEV||IL (BEER SHEVA)||participant||260˙300.00|
|9||ENANTIS SRO||CZ (BRNO)||participant||232˙422.00|
|10||FAKULTNI NEMOCNICE U SV. ANNY V BRNE||CZ (Brno)||participant||232˙422.00|
|11||Alzheimer's Research UK||UK (LONDON)||partner||0.00|
|12||Brain AG||DE (Zwingenberg)||partner||0.00|
|13||CAMBRIDGE ENTREPRISE LIMITED||UK (CAMBRIDGE)||partner||0.00|
|14||DROP-TECH LTD||UK (Cambridge)||partner||0.00|
|15||DSM FOOD SPECIALTIES BV||NL (DELFT)||partner||0.00|
|17||GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.||UK (BRENTFORD)||partner||0.00|
|19||NOVOZYMES A/S||DK (BAGSVAERD)||partner||0.00|
ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.
|Open Day||Other||2020-03-23 11:31:14|
|Social media presence (Facebook)||Websites, patent fillings, videos etc.||2020-03-23 11:31:13|
|Website, ESR webpages and CamTools operational||Websites, patent fillings, videos etc.||2020-03-23 11:31:13|
Take a look to the deliverables list in detail: detailed list of ES-Cat deliverables.
|year||authors and title||journal||last update|
Stanislav Mazurenko, Jan Stourac, Antonin Kunka, Sava NedeljkoviÄ‡, David Bednar, Zbynek Prokop, Jiri Damborsky
CalFitter: a web server for analysis of protein thermal denaturation data
published pages: W344-W349, ISSN: 0305-1048, DOI: 10.1093/nar/gky358
|Nucleic Acids Research 46/W1||2020-03-23|
Lenka Sumbalova, Jan Stourac, Tomas Martinek, David Bednar, Jiri Damborsky
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information
published pages: W356-W362, ISSN: 0305-1048, DOI: 10.1093/nar/gky417
|Nucleic Acids Research 46/W1||2020-03-23|
Danielle Dahan, Ioannis Tsirkas, Daniel Dovrat, Melanie A Sparks, Saurabh P Singh, Roberto Galletto, Amir Aharoni
Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures
published pages: 11847-11857, ISSN: 0305-1048, DOI: 10.1093/nar/gky1065
|Nucleic Acids Research 46/22||2020-03-23|
Daniel Dovrat, Danielle Dahan, Shachar Sherman, Ioannis Tsirkas, Natalie Elia, Amir Aharoni
A Live-Cell Imaging Approach for Measuring DNA Replication Rates
published pages: 252-258, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.06.018
|Cell Reports 24/1||2020-03-23|
Koen Beerens, Stanislav Mazurenko, Antonin Kunka, Sergio M. Marques, Niels Hansen, Milos Musil, Radka Chaloupkova, Jitka Waterman, Jan Brezovsky, David Bednar, Zbynek Prokop, Jiri Damborsky
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization
published pages: 9420-9428, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b01677
|ACS Catalysis 8/10||2020-03-23|
Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova, Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova, Jan Brezovsky, Zbynek Prokop, Jiri Damborsky
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization
published pages: 2402-2412, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b03523
|ACS Catalysis 8/3||2020-03-23|
Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-21887-9
|Scientific Reports 8/1||2020-03-23|
Dana Koslawsky, Marianna Zaretsky, Ron Alcalay, Ohad Mazor, Amir Aharoni, Niv Papo
A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.25526
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The information about "ES-CAT" are provided by the European Opendata Portal: CORDIS opendata.
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