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ES-Cat SIGNED

Directed Protein Evolution for Synthetic Biology and Biocatalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ES-Cat project word cloud

Explore the words cloud of the ES-Cat project. It provides you a very rough idea of what is the project "ES-Cat" about.

industrial    biotechnology    microfluidics    represented    complementary    protein    tool    benefits    efforts    screening    near    times    mechanisms    ribozyme    experimental    harvest    efficient    evident    handling    snap    groups    robotic    systematic    ready    lab    economic    perfection    proteins    enzymes    combining    bio    levels    academic    rational    space    display    seeing    molecular    rivaling    socio    biophysical    integration    evolution    move    sequence    functions    laboratory    diverse    biology    disciplines    brings    alternatives    engineering    kinetic    perform    nature    libraries    harnessing    structural    chip    cat    train    phage    network    screen    optimize    enzyme    fill    exploration    made    medicine    instead    biocatalyst    forces    creative    campaigns    machines    roles    directed    combine    tailoring    subsequent    shorten    liquid    darwinian    es    generation    throughput    manipulated    combinatorial    silico    skills    synthetic    applicable    remarkable    smarter    economy    reproduce    generate   

Project "ES-Cat" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://es-cat.online/
 Total cost 3˙827˙031 €
 EC max contribution 3˙827˙031 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 273˙287.00
2    MEDIMMUNE LIMITED UK (CAMBRIDGE) participant 546˙575.00
3    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 510˙748.00
4    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 501˙120.00
5    UNIVERSITAET GREIFSWALD DE (GREIFSWALD) participant 498˙432.00
6    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER DE (MUENSTER) participant 498˙432.00
7    JOHNSON MATTHEY PLC UK (LONDON) participant 273˙287.00
8    BEN-GURION UNIVERSITY OF THE NEGEV IL (BEER SHEVA) participant 260˙300.00
9    ENANTIS SRO CZ (BRNO) participant 232˙422.00
10    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 232˙422.00
11    Alzheimer's Research UK UK (LONDON) partner 0.00
12    Brain AG DE (Zwingenberg) partner 0.00
13    CAMBRIDGE ENTREPRISE LIMITED UK (CAMBRIDGE) partner 0.00
14    DROP-TECH LTD UK (Cambridge) partner 0.00
15    DSM FOOD SPECIALTIES BV NL (DELFT) partner 0.00
16    Enzymicals DE (GREIFSWALD) partner 0.00
17    GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. UK (BRENTFORD) partner 0.00
18    Kamada IL (Ness-Ziona) partner 0.00
19    NOVOZYMES A/S DK (BAGSVAERD) partner 0.00

Map

 Project objective

ES-Cat will use directed evolution as a tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. Instead of seeing rational and combinatorial approaches as alternatives, we combine them in this network to achieve a ‘smarter’ and more efficient exploration of protein sequence space. By harnessing the forces of Darwinian evolution and design in the laboratory we want to (i) screen large and diverse libraries for proteins with improved and useful functions, (ii) optimize existing proteins for applications in medicine or biotechnology and (iii) provide a better understanding of how existing enzymes evolved and how enzyme mechanisms can be manipulated. This Network brings together leading academic and industrial groups with diverse and complementary skills. The range of methodologies represented in ES-Cat allows an integrated approach combining in silico structural and sequence analysis with experimental high-throughput screening selection methods (phage-, ribozyme and SNAP display, robotic liquid handling, lab-on-a-chip/microfluidics) with subsequent systematic kinetic and biophysical analysis. This integration of methods and disciplines will improve the likelihood of success of directed evolution campaigns, shorten biocatalyst development times, and make protein engineering applicable to a wider range of industrial targets. It will also train the next generation of creative researchers ready to fill roles in tailoring enzymes and other proteins for industrial application in synthetic biology efforts to move towards a bio-based economy, rivaling advances that are being made in the US and allowing the EU economy to harvest its evident socio-economic benefits.

 Deliverables

List of deliverables.
Open Day Other 2020-03-23 11:31:14
Social media presence (Facebook) Websites, patent fillings, videos etc. 2020-03-23 11:31:13
Website, ESR webpages and CamTools operational Websites, patent fillings, videos etc. 2020-03-23 11:31:13

Take a look to the deliverables list in detail:  detailed list of ES-Cat deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Stanislav Mazurenko, Jan Stourac, Antonin Kunka, Sava Nedeljković, David Bednar, Zbynek Prokop, Jiri Damborsky
CalFitter: a web server for analysis of protein thermal denaturation data
published pages: W344-W349, ISSN: 0305-1048, DOI: 10.1093/nar/gky358
Nucleic Acids Research 46/W1 2020-03-23
2018 Lenka Sumbalova, Jan Stourac, Tomas Martinek, David Bednar, Jiri Damborsky
HotSpot Wizard 3.0: web server for automated design of mutations and smart libraries based on sequence input information
published pages: W356-W362, ISSN: 0305-1048, DOI: 10.1093/nar/gky417
Nucleic Acids Research 46/W1 2020-03-23
2018 Danielle Dahan, Ioannis Tsirkas, Daniel Dovrat, Melanie A Sparks, Saurabh P Singh, Roberto Galletto, Amir Aharoni
Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures
published pages: 11847-11857, ISSN: 0305-1048, DOI: 10.1093/nar/gky1065
Nucleic Acids Research 46/22 2020-03-23
2018 Daniel Dovrat, Danielle Dahan, Shachar Sherman, Ioannis Tsirkas, Natalie Elia, Amir Aharoni
A Live-Cell Imaging Approach for Measuring DNA Replication Rates
published pages: 252-258, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.06.018
Cell Reports 24/1 2020-03-23
2018 Koen Beerens, Stanislav Mazurenko, Antonin Kunka, Sergio M. Marques, Niels Hansen, Milos Musil, Radka Chaloupkova, Jitka Waterman, Jan Brezovsky, David Bednar, Zbynek Prokop, Jiri Damborsky
Evolutionary Analysis As a Powerful Complement to Energy Calculations for Protein Stabilization
published pages: 9420-9428, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b01677
ACS Catalysis 8/10 2020-03-23
2018 Pavel Vanacek, Eva Sebestova, Petra Babkova, Sarka Bidmanova, Lukas Daniel, Pavel Dvorak, Veronika Stepankova, Radka Chaloupkova, Jan Brezovsky, Zbynek Prokop, Jiri Damborsky
Exploration of Enzyme Diversity by Integrating Bioinformatics with Expression Analysis and Biochemical Characterization
published pages: 2402-2412, ISSN: 2155-5435, DOI: 10.1021/acscatal.7b03523
ACS Catalysis 8/3 2020-03-23
2018 Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-21887-9
Scientific Reports 8/1 2020-03-23
2018 Dana Koslawsky, Marianna Zaretsky, Ron Alcalay, Ohad Mazor, Amir Aharoni, Niv Papo
A bi-specific inhibitor targeting IL-17A and MMP-9 reduces invasion and motility in MDA-MB-231 cells
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.25526
Oncotarget 9/47 2020-03-23

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