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CuraBone SIGNED

Predictive models and simulations in bone regeneration: a multiscale patient-specific approach

Total Cost €

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EC-Contrib. €

0

Partnership

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Project "CuraBone" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE ZARAGOZA 

Organization address
address: CALLE PEDRO CERBUNA 12
city: ZARAGOZA
postcode: 50009
website: www.unizar.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://curabone.unizar.es/
 Total cost 1˙247˙425 €
 EC max contribution 1˙247˙425 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE ZARAGOZA ES (ZARAGOZA) coordinator 495˙745.00
2    MATERIALISE NV BE (HEVERLEE) participant 751˙680.00
3    AALBORG UNIVERSITET DK (AALBORG) partner 0.00
4    AnyBody Technology A/S DK (Aalborg) partner 0.00
5    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) partner 0.00
6    LOZANO BLESA HOSPITAL ES (Zaragoza) partner 0.00
7    MAZ HOSPITAL ES (Zaragoza) partner 0.00
8    RJAH ORTHOPAEDIC HOSPITAL UK (Oswestry) partner 0.00
9    TA INSTRUMENTS US (New Castle) partner 0.00

Map

 Project objective

Bone injuries represent a high cost for the European health system, requiring corrective surgery to fix the bones. Traditionally, their treatment relies on classical orthopaedic techniques but, nowadays, it is possible to design and fabricate custom-made implants. Thanks to the current advance in image-based technologies, the reconstruction of models that are exact copies of patient specific bones is possible. Thus, this methodology is appropriate for preoperative surgical planning, but currently lacks of a predictive capacity. It presents a low impact for quantitatively determine the effectiveness of different treatments on bone regeneration and, consequently, the patient recovery. CURABONE aims to bridge this gap, integrating and extending numerical simulation technologies based on image analysis to achieve a predictive methodology, to optimize patient-specific treatment of bone injuries and rehabilitation therapies. Therefore, CURABONE will focus on the establishment of a currently non-existent, but essential multi-validation platform at different scale levels for the creation of bone models. At organ level, patient-specific loads will be quantified from image-based analysis and musculoskeletal rigid-body modelling. At implant level, Finite Element analyses (FEA) of bone and implant/scaffold will be evaluated. At cell level, in-vitro experiments will be developed under controlled microenvironmental conditions in bioreactors to estimate the cell response under different mechanical conditions. All this information obtained from validation at different scales will be integrated in a computational model with a predictive capacity. Hence, CURABONE will not only develop patient-specific musculoskeletal modelling based on FEA and bone adaptive algorithms, but will also bring a step-forward to validate these models at different scales together with supervision of different orthopaedic hospitals expert on bone injuries.

 Deliverables

List of deliverables.
Integrative computer bone healing framework. Documents, reports 2019-07-22 16:45:49
Integrative computer degradation algorithm. Documents, reports 2019-07-22 16:45:47
Integrative computer bone remodelling framework. Documents, reports 2019-07-22 16:45:49
Loading conditions for the humerus and radius. Documents, reports 2019-06-27 14:17:43
Mid Term report Documents, reports 2019-06-27 14:17:43
Loading conditions for the femur and tibia. Documents, reports 2019-06-27 14:17:43
Progress report Documents, reports 2019-06-27 14:17:43
Career Development plans & Declarations on conformity Documents, reports 2019-06-27 14:17:43
Definition of requirements for ESRs recruitment and training Documents, reports 2019-06-27 14:17:43
CuraBone web site release Websites, patent fillings, videos etc. 2019-06-27 14:17:43
Data Management Plan Documents, reports 2019-06-27 14:17:43

Take a look to the deliverables list in detail:  detailed list of CuraBone deliverables.

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The information about "CURABONE" are provided by the European Opendata Portal: CORDIS opendata.

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