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TRAIN SIGNED

Tribbles Research and Innovation Network

Total Cost €

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EC-Contrib. €

0

Partnership

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 TRAIN project word cloud

Explore the words cloud of the TRAIN project. It provides you a very rough idea of what is the project "TRAIN" about.

individual    immune    tumourigenesis    complementary    skills    transferrable    progression    biobanks    backgrounds    biology    govern    plus    training    portfolio    complemented    pipeline    medical    obesity    cutting    models    prognosis    multidisciplinary    physiological    immunity    groups    substantially    tissue    genomics    chemistry    metabolic    proteins    worsened    clinical    integrative    alliance    family    cohort    mediated    disciplines    opportunity    adipocytes    cell    interface    adipose    regulators    serve    discovery    dysregulation    specialist    pseudokinases    prototypical    tribbles    translational    envisaged    uncover    inflammation    examples    academic    holistically    metabolocentric    individuals    integrating    prostate    metabolism    exposure    diseases    phd    expertise    smes    medicinal    context    cancer    human    disease    vivo    cancers    molecular    cells    functioning    edge    tackle    immuno    epithelium    thereby    sectors    diverse    gaining    students    career    reported    sophisticated    drug   

Project "TRAIN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://train-itn.eu
 Total cost 3˙818˙970 €
 EC max contribution 3˙818˙970 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 546˙575.00
2    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) participant 546˙575.00
3    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 510˙748.00
4    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 498˙432.00
5    FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO CLINICO SAN CARLOS ES (MADRID) participant 495˙745.00
6    UNIVERSITE DE NANTES FR (NANTES CEDEX 1) participant 262˙875.00
7    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) participant 247˙872.00
8    INTELLIGENT PHARMA SLU ES (BARCELONA) participant 247˙872.00
9    UNIVERSIDADE DA BEIRA INTERIOR PT (COVILHA) participant 238˙356.00
10    SEQOMICS BIOTECHNOLOGIA KORLATOLT FELELOSSEGU TARSASAG HU (MORAHALOM) participant 223˙913.00
11    Basque Biobank for Research ES (Bilbao) partner 0.00
12    DiverChim FR (ROISSY EN FRANCE) partner 0.00
13    Hospital du 12 Octobre ES (Madrid) partner 0.00
14    Labstract Ltd UK (Cambridge) partner 0.00
15    MRC Technology UK (London) partner 0.00
16    UNIVERSITATSKLINIKUM HEIDELBERG DE (HEIDELBERG) partner 0.00
17    University of Szeged US (CAMBRIDGE) partner 0.00

Map

 Project objective

This proposal was developed in the context of the medical need to tackle the clinical consequences of obesity-related diseases more holistically. Dysregulation of common molecular pathways that govern the physiological functioning of adipocytes, immune cells and prostate epithelium cells have been reported in immuno-metabolic disease (such as obesity) and several cancers. The individual projects described in the proposal will investigate regulators of these pathways with a focus on a recently described family of pseudokinases, namely tribbles proteins, which have a key role in controlling immunity, metabolism and cancer, and which here will serve as prototypical examples for integrative metabolocentric cancer research. Tribbles are envisaged to contribute directly to the development and progression of prostate cancer, the prognosis of which is substantially worsened in individuals with immuno-metabolic disease. We therefore propose a multidisciplinary research-training programme with an overall objective to uncover cell-specific aspects of tribbles-mediated control of immuno-metabolism and their impact on prostate cancer progression. We will approach this by integrating cell biology and sophisticated in vivo models of both immuno-metabolic disease and prostate cancer, complemented by specialist human disease biobanks, cutting-edge genomics approaches, plus a drug discovery pipeline. This will be carried out by an alliance of leading academic research groups and specialist SMEs with complementary backgrounds in inflammation, adipose tissue biology, tumourigenesis, genomics, translational models of human disease, medicinal chemistry and drug discovery. This will provide a unique opportunity for a cohort of PhD students to undertake Research Training at the interface of several disciplines and sectors, thereby gaining a diverse portfolio of R&D expertise and transferrable skills as well as exposure to several non-academic career pathways.

 Deliverables

List of deliverables.
8.1 Documents, reports 2019-08-20 18:04:14
7.1 Websites, patent fillings, videos etc. 2019-08-20 18:04:14
8.3 Documents, reports 2019-08-20 18:04:14
8.2 Websites, patent fillings, videos etc. 2019-08-20 18:04:14
5.2 Documents, reports 2019-08-20 18:04:14

Take a look to the deliverables list in detail:  detailed list of TRAIN deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Chiara Niespolo, Juan Salamanca Viloria, Oscar Villacanas Perez, Heather Wilson, Endre Kiss-Toth
Post-transcriptional regulation of trib1 by mirnas in primary macrophages
published pages: , ISSN: , DOI: 10.1136/heartjnl-2018-BCS.109
Heart Volume 104, Issue Supp 6 2019-08-20
2018 Laura Martinez Campesino, Jessica Johnston, Endre Kiss-Toth, Heather Wilson
TRIB3-mediated regulationof macrophage phenotype
published pages: , ISSN: , DOI: 10.1136/heartjnl-2018-BCS.113
Heart Vol 104, Issue Suppl 6 2019-08-20
2017 Jack P Green, Celine Souilhol, Ioannis Xanthis, Laura Martinez-Campesino, Neil P Bowden, Paul C Evans, Heather L Wilson
Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling
published pages: 324-335, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx213
Cardiovascular Research 114/2 2019-08-20
2018 Jessica M Johnston, Sheila E Francis, Endre Kiss-Toth
Experimental models of murine atherosclerosis: does perception match reality?
published pages: , ISSN: 0008-6363, DOI: 10.1093/cvr/cvy140
Cardiovascular Research 2019-08-20

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The information about "TRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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