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in3 SIGNED

An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment

Total Cost €

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EC-Contrib. €

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Partnership

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 in3 project word cloud

Explore the words cloud of the in3 project. It provides you a very rough idea of what is the project "in3" about.

phd    esrs    compounds    expertise    identical    liver    animals    nm    data    designed    acquire    hone    training    man    drugs    cosmetics    15    backgrounds    assays    silico    adverse    students    quantitative    testable    protocols    significantly    cancerous    cheminformatics    stage    tissues    solving    secondments    cells    ideal    appropriately    scientific    create    chemicals    biokinetics    donor    skill    stem    brain    evaluation    human    computational    utilise    derive    safety    kidney    all    housed    improvements    agrochemicals    platform    vasculature    nanomaterial    tested    suffering    toxicology    burden    interdisciplinary    integrating    vitro    environment    strategy    hipsc    prediction    risk    software    standardised    chemical    species    genetic    in3    free    lack    graduate    packages    advantages    interaction    dependent    realisation    animal    carry    near    lung    accelerate    models    annotated    utilising    chosen    formats    techniques    collaborate    outcome    linked    pluripotent    material    mechanistic    skills    centrally   

Project "in3" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.estiv.org/in3/
 Total cost 3˙860˙843 €
 EC max contribution 3˙860˙843 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 510˙748.00
2    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI IT (MILANO) participant 516˙122.00
3    Department of Health UK (Leeds) participant 273˙287.00
4    LIVERPOOL JOHN MOORES UNIVERSITY UK (LIVERPOOL) participant 273˙287.00
5    NEWCELLS BIOTECH LIMITED UK (NEWCASTLE UPON TYNE) participant 273˙287.00
6    EDELWEISS CONNECT GMBH CH (BASEL) participant 265˙226.00
7    UNIVERSITE DE LAUSANNE CH (LAUSANNE) participant 265˙226.00
8    UNIVERSITE D'ARTOIS FR (ARRAS) participant 262˙875.00
9    EVERCYTE GMBH AT (WIEN) participant 255˙934.00
10    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 255˙374.00
11    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 250˙560.00
12    KEMIJSKI INSTITUT SI (LJUBLJANA) participant 234˙997.00
13    BIOTALENTUM TUDASFEJLESZTO KFT HU (GOEDOELLO) participant 223˙913.00
14    MEDIZINISCHE UNIVERSITAT INNSBRUCK AT (INNSBRUCK) participant 0.00
15    European Society of Toxicology in Vitro NL (Soesterberg) partner 0.00
16    European Union Reference Laboratory for Alternative Methods to Animal Testing IT (Ispra) partner 0.00
17    L'OREAL SA FR (PARIS) partner 0.00
18    NANOTECH PARTNER SRO CZ (PRAHA) partner 0.00
19    UNIVERSITAT KONSTANZ DE (KONSTANZ) partner 0.00

Map

 Project objective

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.

 Deliverables

List of deliverables.
Distribution of Recruitment advertisement and application form Other 2019-07-05 12:30:19
Establish in3 web page Websites, patent fillings, videos etc. 2019-07-05 12:30:19

Take a look to the deliverables list in detail:  detailed list of in3 deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Caroline Rauch, Elisabeth Feifel, Georg Kern, Cormac Murphy, Florian Meier, Walther Parson, Mario Beilmann, Paul Jennings, Gerhard Gstraunthaler, Anja Wilmes
Differentiation of human iPSCs into functional podocytes
published pages: e0203869, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0203869
PLOS ONE 13/9 2019-07-05

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The information about "IN3" are provided by the European Opendata Portal: CORDIS opendata.

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