Explore the words cloud of the in3 project. It provides you a very rough idea of what is the project "in3" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||3˙860˙843 €|
|EC max contribution||3˙860˙843 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||STICHTING VU||NL (AMSTERDAM)||coordinator||510˙748.00|
|2||ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI||IT (MILANO)||participant||516˙122.00|
|3||Department of Health||UK (Leeds)||participant||273˙287.00|
|4||LIVERPOOL JOHN MOORES UNIVERSITY||UK (LIVERPOOL)||participant||273˙287.00|
|5||NEWCELLS BIOTECH LIMITED||UK (NEWCASTLE UPON TYNE)||participant||273˙287.00|
|6||EDELWEISS CONNECT GMBH||CH (BASEL)||participant||265˙226.00|
|7||UNIVERSITE DE LAUSANNE||CH (LAUSANNE)||participant||265˙226.00|
|8||UNIVERSITE D'ARTOIS||FR (ARRAS)||participant||262˙875.00|
|9||EVERCYTE GMBH||AT (WIEN)||participant||255˙934.00|
|10||UNIVERSITEIT UTRECHT||NL (UTRECHT)||participant||255˙374.00|
|11||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||250˙560.00|
|12||KEMIJSKI INSTITUT||SI (LJUBLJANA)||participant||234˙997.00|
|13||BIOTALENTUM TUDASFEJLESZTO KFT||HU (GOEDOELLO)||participant||223˙913.00|
|14||MEDIZINISCHE UNIVERSITAT INNSBRUCK||AT (INNSBRUCK)||participant||0.00|
|15||European Society of Toxicology in Vitro||NL (Soesterberg)||partner||0.00|
|16||European Union Reference Laboratory for Alternative Methods to Animal Testing||IT (Ispra)||partner||0.00|
|17||L'OREAL SA||FR (PARIS)||partner||0.00|
|18||NANOTECH PARTNER SRO||CZ (PRAHA)||partner||0.00|
|19||UNIVERSITAT KONSTANZ||DE (KONSTANZ)||partner||0.00|
All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.
|Distribution of Recruitment advertisement and application form||Other||2019-07-05 12:30:19|
|Establish in3 web page||Websites, patent fillings, videos etc.||2019-07-05 12:30:19|
Take a look to the deliverables list in detail: detailed list of in3 deliverables.
|year||authors and title||journal||last update|
Caroline Rauch, Elisabeth Feifel, Georg Kern, Cormac Murphy, Florian Meier, Walther Parson, Mario Beilmann, Paul Jennings, Gerhard Gstraunthaler, Anja Wilmes
Differentiation of human iPSCs into functional podocytes
published pages: e0203869, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0203869
|PLOS ONE 13/9||2019-07-05|
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The information about "IN3" are provided by the European Opendata Portal: CORDIS opendata.
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