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in3 SIGNED

An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

in3 project word cloud

Explore the words cloud of the in3 project. It provides you a very rough idea of what is the project "in3" about.

mechanistic all standardised tissues carry human genetic toxicology formats material cancerous backgrounds quantitative environment cosmetics biokinetics students risk interdisciplinary software graduate nanomaterial centrally vitro interaction in3 kidney compounds liver drugs computational chemicals significantly dependent man platform testable near ideal packages assays scientific tested integrating chemical appropriately outcome lack animal esrs collaborate phd models evaluation safety hone stage species create prediction free realisation cells protocols strategy silico training acquire burden linked housed brain expertise animals chosen improvements accelerate nm annotated advantages skills lung agrochemicals skill 15 vasculature cheminformatics hipsc secondments solving techniques identical donor adverse data stem utilising derive designed pluripotent suffering utilise

Project "in3" data sheet

The following table provides information about the project.

Coordinator	STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.estiv.org/in3/
Total cost	3˙860˙843 €
EC max contribution	3˙860˙843 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING VU STICHTING VU Organization address address: DE BOELELAAN 1105 city: AMSTERDAM postcode: 1081 HV website: www.vu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	510˙748.00
2	ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Organization address address: VIA MARIO NEGRI 2 city: MILANO postcode: 20156 website: www.marionegri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	516˙122.00
3	Department of Health Department of Health Organization address address: Quarry House, Quarry Hill city: Leeds postcode: LS2 7UE website: www.dh.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Leeds)	participant	273˙287.00
4	LIVERPOOL JOHN MOORES UNIVERSITY LIVERPOOL JOHN MOORES UNIVERSITY Organization address address: RODNEY STREET 2 EGERTON COURT city: LIVERPOOL postcode: L3 5UX website: www.ljmu.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	273˙287.00
5	NEWCELLS BIOTECH LIMITED NEWCELLS BIOTECH LIMITED Organization address address: 1 TIMES SQUARE SCOTSWOOD ROAD city: NEWCASTLE UPON TYNE postcode: NE1 4EP website: http://www.newcellsbiotech.co.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	273˙287.00
6	EDELWEISS CONNECT GMBH EDELWEISS CONNECT GMBH Organization address address: HOCHBERGERSTRASSE 60C city: BASEL postcode: 4057 website: http://www.douglasconnect.com/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	265˙226.00
7	UNIVERSITE DE LAUSANNE UNIVERSITE DE LAUSANNE Organization address address: Quartier Unil-Centre Bâtiment Unicentre city: LAUSANNE postcode: 1015 website: www.unil.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	265˙226.00
8	UNIVERSITE D'ARTOIS UNIVERSITE D'ARTOIS Organization address address: RUE DU TEMPLE 9 city: ARRAS postcode: 62000 website: www.univ-artois.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (ARRAS)	participant	262˙875.00
9	EVERCYTE GMBH EVERCYTE GMBH Organization address address: MUTHGASSE 18 city: WIEN postcode: 1190 website: www.evercyte.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	255˙934.00
10	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	255˙374.00
11	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	250˙560.00
12	KEMIJSKI INSTITUT KEMIJSKI INSTITUT Organization address address: HAJDRIHOVA 19 city: LJUBLJANA postcode: 1000 website: http://www.ki.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	234˙997.00
13	BIOTALENTUM TUDASFEJLESZTO KFT BIOTALENTUM TUDASFEJLESZTO KFT Organization address address: AULICH LAJOS UTCA 26 city: GOEDOELLO postcode: 2100 website: www.biotalentum.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (GOEDOELLO)	participant	223˙913.00
14	MEDIZINISCHE UNIVERSITAT INNSBRUCK MEDIZINISCHE UNIVERSITAT INNSBRUCK Organization address address: CHRISTOPH PROBST PLATZ 1 city: INNSBRUCK postcode: 6020 website: www.i-med.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (INNSBRUCK)	participant	0.00
15	European Society of Toxicology in Vitro European Society of Toxicology in Vitro Organization address address: n.a. city: Soesterberg postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Soesterberg)	partner	0.00
16	European Union Reference Laboratory for Alternative Methods to Animal Testing European Union Reference Laboratory for Alternative Methods to Animal Testing Organization address address: n.a. city: Ispra postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Ispra)	partner	0.00
17	L'OREAL SA L'OREAL SA Organization address address: 14 RUE ROYALE city: PARIS postcode: 75008 website: www.loreal.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	partner	0.00
18	NANOTECH PARTNER SRO NANOTECH PARTNER SRO Organization address address: VACLAVSKE NAMESTI 808 66 NOVE MESTO city: PRAHA postcode: 110 00 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA)	partner	0.00
19	UNIVERSITAT KONSTANZ UNIVERSITAT KONSTANZ Organization address address: UNIVERSITATSSTRASSE 10 city: KONSTANZ postcode: 78464 website: www.uni-konstanz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KONSTANZ)	partner	0.00

Map

Project objective

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering. While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The project aims to accelerate the realisation of animal-free safety assessment and to graduate 15 PhD students with the ideal skill sets to carry out the strategy designed in in3 in the near future.

Deliverables

List of deliverables.
Distribution of Recruitment advertisement and application form	Other	2019-07-05 12:30:19
Establish in3 web page	Websites, patent fillings, videos etc.	2019-07-05 12:30:19

Take a look to the deliverables list in detail: detailed list of in3 deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Caroline Rauch, Elisabeth Feifel, Georg Kern, Cormac Murphy, Florian Meier, Walther Parson, Mario Beilmann, Paul Jennings, Gerhard Gstraunthaler, Anja Wilmes Differentiation of human iPSCs into functional podocytes published pages: e0203869, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0203869	PLOS ONE 13/9	2019-07-05

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The information about "IN3" are provided by the European Opendata Portal: CORDIS opendata.

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