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GlySign SIGNED

Exploitation of Glycosylation Signatures for Precision Medicine

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GlySign" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.glysign.eu/
 Total cost 1˙552˙846 €
 EC max contribution 1˙552˙846 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EID
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 510˙748.00
2    LUDGER LIMITED UK (ABINGDON) participant 546˙575.00
3    GENOS DOO ZA VJESTACENJE I ANALIZU HR (OSIJEK) participant 495˙522.00
4    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) partner 0.00
5    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) partner 0.00
6    PROZOMIX LIMITED UK (HALTWHISTLE) partner 0.00
7    Stichting Sanquin Bloedvoorziening NL (Amsterdam) partner 0.00

Map

 Project objective

GlySign is a research training network for the translation of glycomic clinical biomarkers for Precision Medicine (PM). Complex, distinctive changes occur in the glycomics profiles or - Glycan Signatures - of human glycoproteins during progression of many chronic diseases including cancer and inflammatory conditions. The three beneficiaries of the GlySign Consortium have been instrumental in contributing to knowledge in this field through development of glycomics technology and discovery of clinically important novel glycan biomarkers in a variety of diseases. Glycan signatures have great potential for adding useful diagnostic and prognostic information in PM. However, advancement of this field is slow because (a) glycans have immense structural complexity resulting in major technical challenges for their analysis and (b) there is a lack of experts with required glycoanalytical skills. GlySign will address this gap by training six young scientists within an innovative training-by-research programme with high industrial-academic mobility to eventually push forward the translation of novel glycomics-based diagnostic tools into clinical practice. This will be achieved by further developing a range of selective and sensitive glycomics technologies for the analysis of samples from patients and healthy controls in close collaboration between industry/academia as well as clinical chemists and clinicians who will be the end users of GlySign’s final products. To this end, we will focus the training on clinical glycomics applied to four model diseases implicating changes in the glycosylation of circulating proteins specific to disease progression or subtype, i.e. diabetes, prostate cancer, fetal and neonatal alloimmune thrombocytopenia and rheumatoid arthritis. Due to its strong industrial and translational focus, GlySign will, moreover, fill a current gap in the market by establishing new in vitro diagnostic platforms for clinical exploitation of glycomic biomarkers for PM.

 Deliverables

List of deliverables.
Website established Websites, patent fillings, videos etc. 2019-03-20 15:56:20

Take a look to the deliverables list in detail:  detailed list of GlySign deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population
published pages: 1273-1287, ISSN: 1752-0363, DOI: 10.2217/bmm-2019-0005
Biomarkers in Medicine 13/15 2020-02-06
2020 Clemens Wittenbecher, Tamara Štambuk, Olga Kuxhaus, Najda Rudman, Frano Vučković, Jerko Štambuk, Catarina Schiborn, Dario Rahelić, Stefan Dietrich, Olga Gornik, Markus Perola, Heiner Boeing, Matthias B. Schulze, Gordan Lauc
Plasma N -Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study
published pages: dc191507, ISSN: 0149-5992, DOI: 10.2337/dc19-1507
Diabetes Care 2020-02-06
2019 Tanya M. Monaghan, Maja Pučić-Baković, Frano Vučković, Christine Lee, Dina Kao, Iwona Wójcik, Filip Kliček, Christos Polytarchou, Brandi Roach, Tom Louie, Peter Kim, Brandi Roach, Christos Polytarchou, Marcin Frankowski, Gordan Lauc
Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection
published pages: 1676-1678.e3, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.08.034
Gastroenterology 157/6 2020-02-06
2019 Najda Rudman, Olga Gornik, Gordan Lauc
Altered N‐glycosylation profiles as potential biomarkers and drug targets in diabetes
published pages: 1598-1615, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13495
FEBS Letters 593/13 2020-02-06
2019 Jiaonan Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, Jie Zhang, Jinxia Zhang, Hao Wang, Xiaoni Meng, Genadij Razdorov, Desmond Menon, Deqiang Zheng, Lijuan Wu, Youxin Wang, Manshu Song, Gordan Lauc, Wei Wang
Glycomics for Type 2 Diabetes Biomarker Discovery: Promise of Immunoglobulin G Subclass-Specific Fragment Crystallizable N-glycosylation in the Uyghur Population
published pages: 640-648, ISSN: 1557-8100, DOI: 10.1089/omi.2019.0052
OMICS: A Journal of Integrative Biology 23/12 2020-02-06
2017 Xia Shen, Lucija Klarić, Sodbo Sharapov, Massimo Mangino, Zheng Ning, Di Wu, Irena Trbojević-Akmačić, Maja Pučić-Baković, Igor Rudan, Ozren Polašek, Caroline Hayward, Timothy D. Spector, James F. Wilson, Gordan Lauc, Yurii S. Aulchenko
Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00453-3
Nature Communications 8/1 2019-04-18
2019 Eric Adua, Elham Memarian, Alyce Russell, Irena Trbojević-Akmačić, Ivan Gudelj, Julija Jurić, Peter Roberts, Gordan Lauc, Wei Wang
High throughput profiling of whole plasma N-glycans in type II diabetes mellitus patients and healthy individuals: A perspective from a Ghanaian population
published pages: 10-21, ISSN: 0003-9861, DOI: 10.1016/j.abb.2018.10.015
Archives of Biochemistry and Biophysics 661 2019-04-18
2018 Zejian Zhang, Manfred Wuhrer, Stephanie Holst
Serum sialylation changes in cancer
published pages: 139-160, ISSN: 0282-0080, DOI: 10.1007/s10719-018-9820-0
Glycoconjugate Journal 35/2 2019-04-18
2018 Cristina Menni, Ivan Gudelj, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Erim Bešić, Peter K. Joshi, Irena Trbojević-Akmačić, Phil J. Chowienczyk, Tim D. Spector, James F. Wilson, Gordan Lauc, Ana M. Valdes
Glycosylation Profile of Immunoglobulin G Is Cross-Sectionally Associated With Cardiovascular Disease Risk Score and Subclinical Atherosclerosis in Two Independent Cohorts
published pages: 1555-1564, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.312174
Circulation Research 122/11 2019-04-18
2018 Ivan Gudelj, Perttu P. Salo, Irena Trbojević-Akmačić, Malena Albers, Dragan Primorac, Markus Perola, Gordan Lauc
Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
published pages: 2034-2039, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2018.03.018
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/6 2019-04-18

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