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chemos SIGNED

Chemical Hematology: breaking resistance of hematological malignancies through personalized drug trials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 chemos project word cloud

Explore the words cloud of the chemos project. It provides you a very rough idea of what is the project "chemos" about.

immune    bone    treatment    lymphoma    investors    intend    retrospective    service    broad    individual    commercialization    screening    compounds    score    cell    thousands    incorporate    grant    automated    aspires    population    fluorescent    time    oncologists    possibility    peripheral    diseases    drugs    empowers    efforts    probes    erc    profiles    human    microscopy    small    trials    samples    spectrum    discovery    liquid    single    individuals    setting    inflammatory    antibodies    plan    therapy    mind    hematological    disorders    intellectual    obtain    termed    modulating    viral    primary    relevance    manner    believe    patient    cells    tracking    attractive    image    falls    began    methodology    medicine    decision    drug    optimal    data    agents    course    capability    sub    tissues    settings    neoplastic    marrow    rights    myelofibrosis    pharmacoscopy    chemos    anti    physiological    invented    hema    draw    personalized    blood    secured    assembled    clinical    cytotoxicity    quest    therapeutic    property   

Project "chemos" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 146˙668 €
 EC max contribution 146˙668 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 146˙668.00

Map

 Project objective

Personalized medicine aspires to provide optimal therapy in real-time during patient treatment, however current methodology falls short to deliver this in a robust manner. With this in mind, we invented a method for the screening of thousands of drug responses in small samples of an individual’s peripheral blood by automated microscopy and single-cell image analysis. We termed this method pharmacoscopy. In the course of carrying out the i-FIVE ERC grant project plan, we began screening for novel anti-viral or immune modulating drugs. In the quest to increase the physiological relevance of our screening settings, we investigated the possibility of using peripheral blood cells or bone marrow from individuals. We have thus far been able to show that the approach allows for the screening of anti-inflammatory properties of compounds, and to score for distinct sub-population specific cell cytotoxicity profiles of clinical anti-neoplastic agents through the tracking of fluorescent antibodies and probes. Moreover, we have been able to show that the approach empowers the therapeutic decision-making capability of hema-oncologists in a concrete clinical setting using primary myelofibrosis and lymphoma as test diseases. With funding from this grant, we intend to obtain further clinical data through retrospective trials, and incorporate the results into an information package attractive enough to draw the attention of potential investors. We have secured the intellectual property rights and have assembled the know-how required to enable commercialization efforts. With the unique image-based single cell analysis of human liquid tissues, we believe that chemos has the potential to develop into a service that enables and advances personalized medicine and drug discovery for a broad spectrum of hematological disorders.

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The information about "CHEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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