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chemos SIGNED

Chemical Hematology: breaking resistance of hematological malignancies through personalized drug trials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 chemos project word cloud

Explore the words cloud of the chemos project. It provides you a very rough idea of what is the project "chemos" about.

myelofibrosis    population    diseases    property    capability    sub    attractive    therapeutic    peripheral    rights    individual    treatment    investors    thousands    cytotoxicity    efforts    antibodies    began    image    possibility    assembled    service    profiles    disorders    patient    time    individuals    tissues    termed    drug    falls    draw    personalized    therapy    inflammatory    incorporate    plan    neoplastic    intellectual    microscopy    mind    course    optimal    automated    cells    chemos    invented    single    agents    modulating    marrow    empowers    compounds    primary    probes    manner    drugs    trials    pharmacoscopy    cell    broad    hematological    human    commercialization    methodology    data    hema    liquid    settings    immune    spectrum    secured    grant    decision    aspires    score    anti    screening    intend    clinical    small    setting    obtain    believe    lymphoma    retrospective    blood    viral    physiological    quest    tracking    bone    erc    fluorescent    medicine    relevance    samples    discovery    oncologists   

Project "chemos" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 146˙668 €
 EC max contribution 146˙668 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 146˙668.00

Map

 Project objective

Personalized medicine aspires to provide optimal therapy in real-time during patient treatment, however current methodology falls short to deliver this in a robust manner. With this in mind, we invented a method for the screening of thousands of drug responses in small samples of an individual’s peripheral blood by automated microscopy and single-cell image analysis. We termed this method pharmacoscopy. In the course of carrying out the i-FIVE ERC grant project plan, we began screening for novel anti-viral or immune modulating drugs. In the quest to increase the physiological relevance of our screening settings, we investigated the possibility of using peripheral blood cells or bone marrow from individuals. We have thus far been able to show that the approach allows for the screening of anti-inflammatory properties of compounds, and to score for distinct sub-population specific cell cytotoxicity profiles of clinical anti-neoplastic agents through the tracking of fluorescent antibodies and probes. Moreover, we have been able to show that the approach empowers the therapeutic decision-making capability of hema-oncologists in a concrete clinical setting using primary myelofibrosis and lymphoma as test diseases. With funding from this grant, we intend to obtain further clinical data through retrospective trials, and incorporate the results into an information package attractive enough to draw the attention of potential investors. We have secured the intellectual property rights and have assembled the know-how required to enable commercialization efforts. With the unique image-based single cell analysis of human liquid tissues, we believe that chemos has the potential to develop into a service that enables and advances personalized medicine and drug discovery for a broad spectrum of hematological disorders.

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The information about "CHEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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