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chemos SIGNED

Chemical Hematology: breaking resistance of hematological malignancies through personalized drug trials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 chemos project word cloud

Explore the words cloud of the chemos project. It provides you a very rough idea of what is the project "chemos" about.

anti    blood    drug    erc    discovery    agents    empowers    clinical    neoplastic    settings    incorporate    cytotoxicity    microscopy    spectrum    invented    decision    hema    fluorescent    commercialization    efforts    compounds    pharmacoscopy    tissues    believe    single    immune    obtain    chemos    personalized    intellectual    lymphoma    course    capability    profiles    peripheral    medicine    inflammatory    quest    patient    setting    bone    therapy    treatment    attractive    score    sub    data    relevance    service    tracking    intend    modulating    secured    rights    antibodies    optimal    possibility    physiological    cells    individuals    aspires    marrow    disorders    individual    small    property    mind    samples    time    population    image    screening    cell    began    diseases    retrospective    plan    myelofibrosis    draw    methodology    primary    probes    thousands    assembled    hematological    investors    therapeutic    grant    broad    trials    termed    viral    oncologists    manner    liquid    human    falls    automated    drugs   

Project "chemos" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 146˙668 €
 EC max contribution 146˙668 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 146˙668.00

Map

 Project objective

Personalized medicine aspires to provide optimal therapy in real-time during patient treatment, however current methodology falls short to deliver this in a robust manner. With this in mind, we invented a method for the screening of thousands of drug responses in small samples of an individual’s peripheral blood by automated microscopy and single-cell image analysis. We termed this method pharmacoscopy. In the course of carrying out the i-FIVE ERC grant project plan, we began screening for novel anti-viral or immune modulating drugs. In the quest to increase the physiological relevance of our screening settings, we investigated the possibility of using peripheral blood cells or bone marrow from individuals. We have thus far been able to show that the approach allows for the screening of anti-inflammatory properties of compounds, and to score for distinct sub-population specific cell cytotoxicity profiles of clinical anti-neoplastic agents through the tracking of fluorescent antibodies and probes. Moreover, we have been able to show that the approach empowers the therapeutic decision-making capability of hema-oncologists in a concrete clinical setting using primary myelofibrosis and lymphoma as test diseases. With funding from this grant, we intend to obtain further clinical data through retrospective trials, and incorporate the results into an information package attractive enough to draw the attention of potential investors. We have secured the intellectual property rights and have assembled the know-how required to enable commercialization efforts. With the unique image-based single cell analysis of human liquid tissues, we believe that chemos has the potential to develop into a service that enables and advances personalized medicine and drug discovery for a broad spectrum of hematological disorders.

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The information about "CHEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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