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chemos SIGNED

Chemical Hematology: breaking resistance of hematological malignancies through personalized drug trials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 chemos project word cloud

Explore the words cloud of the chemos project. It provides you a very rough idea of what is the project "chemos" about.

attractive    methodology    hematological    profiles    disorders    believe    bone    physiological    course    relevance    optimal    compounds    primary    antibodies    treatment    agents    probes    human    rights    peripheral    sub    intend    data    population    microscopy    termed    efforts    mind    assembled    cytotoxicity    myelofibrosis    began    single    marrow    intellectual    neoplastic    secured    time    hema    anti    manner    broad    image    quest    commercialization    thousands    erc    decision    drugs    lymphoma    spectrum    retrospective    screening    aspires    chemos    therapy    tracking    small    trials    drug    discovery    immune    automated    service    blood    clinical    draw    score    therapeutic    individuals    falls    plan    personalized    cell    patient    cells    liquid    samples    investors    tissues    grant    inflammatory    settings    modulating    obtain    setting    viral    individual    medicine    empowers    possibility    capability    incorporate    pharmacoscopy    property    fluorescent    oncologists    diseases    invented   

Project "chemos" data sheet

The following table provides information about the project.

Coordinator
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH 

Organization address
address: LAZARETTGASSE 14 AKH BT 25.3
city: WIEN
postcode: 1090
website: http://www.oeaw.ac.at/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 146˙668 €
 EC max contribution 146˙668 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) coordinator 146˙668.00

Map

 Project objective

Personalized medicine aspires to provide optimal therapy in real-time during patient treatment, however current methodology falls short to deliver this in a robust manner. With this in mind, we invented a method for the screening of thousands of drug responses in small samples of an individual’s peripheral blood by automated microscopy and single-cell image analysis. We termed this method pharmacoscopy. In the course of carrying out the i-FIVE ERC grant project plan, we began screening for novel anti-viral or immune modulating drugs. In the quest to increase the physiological relevance of our screening settings, we investigated the possibility of using peripheral blood cells or bone marrow from individuals. We have thus far been able to show that the approach allows for the screening of anti-inflammatory properties of compounds, and to score for distinct sub-population specific cell cytotoxicity profiles of clinical anti-neoplastic agents through the tracking of fluorescent antibodies and probes. Moreover, we have been able to show that the approach empowers the therapeutic decision-making capability of hema-oncologists in a concrete clinical setting using primary myelofibrosis and lymphoma as test diseases. With funding from this grant, we intend to obtain further clinical data through retrospective trials, and incorporate the results into an information package attractive enough to draw the attention of potential investors. We have secured the intellectual property rights and have assembled the know-how required to enable commercialization efforts. With the unique image-based single cell analysis of human liquid tissues, we believe that chemos has the potential to develop into a service that enables and advances personalized medicine and drug discovery for a broad spectrum of hematological disorders.

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The information about "CHEMOS" are provided by the European Opendata Portal: CORDIS opendata.

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