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MultimodalCellTrack SIGNED

Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies

Total Cost €

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EC-Contrib. €

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Partnership

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 MultimodalCellTrack project word cloud

Explore the words cloud of the MultimodalCellTrack project. It provides you a very rough idea of what is the project "MultimodalCellTrack" about.

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Project "MultimodalCellTrack" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2018-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

Our inability to accurately monitor the biodistribution of transplanted cells is a major barrier to assessing the safety and efficacy of cell-based regenerative medicine therapies. To assess safety, it is important to know if cells have engrafted into non-target organs so that possible adverse effects can be monitored over time; and to assess efficacy, it is crucial to know what proportion of cells reach the target organ, for how long they persist, and whether they ameliorate injury. Various imaging technologies, including magnetic resonance imaging (MRI), bioluminescence imaging and photoacoustic imaging can be used for monitoring cellular biodistribution and assessing the effect of the cells on host organs and tissues, but no single technique provides high sensitivity, spatial and temporal resolution, and functional and anatomical imaging. It is therefore necessary to combine several imaging approaches.

The University of Liverpool is leading the UK Regenerative Medicine Platform Safety and Efficacy Hub. The hub includes all members of the supervisory team. The University has just inaugurated its new centre for preclinical imaging which brings together in a single place a unique suite of state of the art imaging modalities (including high field MRI and photoacoustic imaging).

Building on her wide experience in the synthesis, functionalization and assembly of nano/micro-particles gained during her PhD with Irshad Hussain (Pakistan) and a Humboldt Fellowship with Wolfgang Parak (Germany), Sumaira Ashraf (the applicant) will prepare probes tailored for cell labelling and multimodal imaging. She will evaluate and optimize the properties of the probes following cell uptake (live cell imaging, magnetophoresis, etc) and finally test the most promising multimodal probes in mouse models of injury that are established within the UKRMP hub.

 Publications

year authors and title journal last update
List of publications.
2018 Sumaira Ashraf, Arthur Taylor, Jack Sharkey, Michael Barrow, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew J. Rosseinsky, Dave Adams and Raphael Levy
In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells
published pages: , ISSN: 2516-0230, DOI: 10.1039/c8na00098k
Nanoscale advances Monthly 2019-06-13
2017 Sumaira Ashraf, Michael Barrow, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew Rosseinsky, & Raphaël Lévy
Multimodal Colloidal Imaging Probes
published pages: , ISSN: , DOI:
Centre for Preclinical Imaging – 3rd Annual Symposium 3rd Annual Symposium 2019-06-13
2017 Sumaira Ashraf
AT THE 254TH ACS CONFERENCE IN WASHINGTON DC
published pages: , ISSN: , DOI:
Blog post 2019-06-13
2017 Sumaira Ashraf, Michael Barrow, Joan Comenge, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Antonius Plagge, Harish Poptani, Matthew Rosseinsky, Raphael Levy
Multimodal stem cell imaging and tracking
published pages: , ISSN: , DOI:
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254 2019-06-13
2017 Sumaira Ashraf, Michael Barrow, Joan Comenge, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew Rosseinsky, & Raphaël Lévy
Multimodal Colloidal Imaging Probes for Cell Tracking
published pages: , ISSN: , DOI:
Northern Postdoctoral Researcher Meeting 3 3 2019-06-13

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