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MultimodalCellTrack SIGNED

Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MultimodalCellTrack project word cloud

Explore the words cloud of the MultimodalCellTrack project. It provides you a very rough idea of what is the project "MultimodalCellTrack" about.

optimize place mouse micro photoacoustic our ukrmp irshad synthesis efficacy functional single modalities liverpool mri time regenerative technologies team supervisory monitored cellular cell brings monitor gained multimodal anatomical monitoring uk adverse provides platform particles phd accurately building hub magnetophoresis assembly bioluminescence centre spatial therapies transplanted effect probes magnetic germany members ashraf ameliorate university imaging fellowship parak hussain tissues preclinical sensitivity sumaira technique barrier combine pakistan labelling host organs safety resolution humboldt medicine functionalization organ injury models temporal engrafted persist assessing live inaugurated cells wolfgang she suite nano resonance proportion prepare biodistribution inability

Project "MultimodalCellTrack" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-08-01 to 2018-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	coordinator	183˙454.00

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Project objective

Our inability to accurately monitor the biodistribution of transplanted cells is a major barrier to assessing the safety and efficacy of cell-based regenerative medicine therapies. To assess safety, it is important to know if cells have engrafted into non-target organs so that possible adverse effects can be monitored over time; and to assess efficacy, it is crucial to know what proportion of cells reach the target organ, for how long they persist, and whether they ameliorate injury. Various imaging technologies, including magnetic resonance imaging (MRI), bioluminescence imaging and photoacoustic imaging can be used for monitoring cellular biodistribution and assessing the effect of the cells on host organs and tissues, but no single technique provides high sensitivity, spatial and temporal resolution, and functional and anatomical imaging. It is therefore necessary to combine several imaging approaches.

The University of Liverpool is leading the UK Regenerative Medicine Platform Safety and Efficacy Hub. The hub includes all members of the supervisory team. The University has just inaugurated its new centre for preclinical imaging which brings together in a single place a unique suite of state of the art imaging modalities (including high field MRI and photoacoustic imaging).

Building on her wide experience in the synthesis, functionalization and assembly of nano/micro-particles gained during her PhD with Irshad Hussain (Pakistan) and a Humboldt Fellowship with Wolfgang Parak (Germany), Sumaira Ashraf (the applicant) will prepare probes tailored for cell labelling and multimodal imaging. She will evaluate and optimize the properties of the probes following cell uptake (live cell imaging, magnetophoresis, etc) and finally test the most promising multimodal probes in mouse models of injury that are established within the UKRMP hub.

Publications

List of publications.
year	authors and title	journal	last update
2018	Sumaira Ashraf, Arthur Taylor, Jack Sharkey, Michael Barrow, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew J. Rosseinsky, Dave Adams and Raphael Levy In vivo fate of free and encapsulated iron oxide nanoparticles after injection of labelled stem cells published pages: , ISSN: 2516-0230, DOI: 10.1039/c8na00098k	Nanoscale advances Monthly	2019-06-13
2017	Sumaira Ashraf, Michael Barrow, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew Rosseinsky, & RaphaÃ«l LÃ©vy Multimodal Colloidal Imaging Probes published pages: , ISSN: , DOI:	Centre for Preclinical Imaging â€“ 3rd Annual Symposium 3rd Annual Symposium	2019-06-13
2017	Sumaira Ashraf AT THE 254TH ACS CONFERENCE IN WASHINGTON DC published pages: , ISSN: , DOI:	Blog post	2019-06-13
2017	Sumaira Ashraf, Michael Barrow, Joan Comenge, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Antonius Plagge, Harish Poptani, Matthew Rosseinsky, Raphael Levy Multimodal stem cell imaging and tracking published pages: , ISSN: , DOI:	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254	2019-06-13
2017	Sumaira Ashraf, Michael Barrow, Joan Comenge, Arthur Taylor, Jack Sharkey, Patricia Murray, Bettina Wilm, Harish Poptani, Matthew Rosseinsky, & RaphaÃ«l LÃ©vy Multimodal Colloidal Imaging Probes for Cell Tracking published pages: , ISSN: , DOI:	Northern Postdoctoral Researcher Meeting 3 3	2019-06-13

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The information about "MULTIMODALCELLTRACK" are provided by the European Opendata Portal: CORDIS opendata.