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CResPace SIGNED

Adaptive Bio-electronics for Chronic Cardiorespiratory Disease

Total Cost €

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EC-Contrib. €

0

Partnership

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 CResPace project word cloud

Explore the words cloud of the CResPace project. It provides you a very rough idea of what is the project "CResPace" about.

life    implants    simpler    bio    electrophysiological    underpinned    neurons    made    disease    disruptive    comorbidities    exceeding    feedback    forget    tools    branch    network    obstacle    assimilate    resolved    arrhythmia    chips    pacemaker    generators    tested    time    beat    adaptive    physiological    multiple    therapy    cpg    extend    neurological    quality    small    compete    data    implements    resynchronization    patients    cardiac    bundle    electronic    validated    nonlinear    issue    accurately    flexible    fit    cpgs    central    models    therapies    cardiorespiratory    apnoea    obtain    rate    networks    benefits    inputs    respiratory    optimization    motor    ventricular    animal    space    functional    neural    sequences    biological    medicine    constructed    heart    arrhythmias    hypertension    trialled    lifespan    atrio    reproduce    multichannel    patient    automatically    pattern    invasive    sleep    building    safer    block    autonomy    pioneer    programming    left    sinus    crespace   

Project "CResPace" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BATH 

Organization address
address: CLAVERTON DOWN
city: BATH
postcode: BA2 7AY
website: http://www.bath.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.crespace.eu
 Total cost 4˙944˙347 €
 EC max contribution 4˙944˙347 € (100%)
 Programme 1. H2020-EU.1.2.2. (FET Proactive)
 Code Call FETPROACT-2016
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BATH UK (BATH) coordinator 1˙548˙936.00
2    UNIVERSITAT ZURICH CH (ZURICH) participant 833˙367.00
3    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 584˙375.00
4    MEDTRONIC BAKKEN RESEARCH CENTER B.V. NL (MAASTRICHT) participant 550˙000.00
5    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 490˙625.00
6    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 431˙668.00
7    MICROSEMI SEMICONDUCTOR LIMITED UK (GWENT) participant 403˙125.00
8    FAKULTNI NEMOCNICE U SV. ANNY V BRNE CZ (Brno) participant 102˙250.00

Map

 Project objective

This consortium will pioneer disruptive technology for bio-electronic medicine to provide much needed therapies for cardiorespiratory and functional neurological disease. The technology implements small neural networks known as central pattern generators (CPG) to deliver fit-and-forget bio-electronic implants that respond to physiological feedback in real time, are safer, simpler, non-invasive, and have autonomy exceeding the patient lifespan. Multichannel neurons will be made to compete on analogue chips to obtain flexible motor sequences underpinned by a wide parameter space. By building large scale nonlinear optimization tools and using them to assimilate electrophysiological data, we will develop a method for automatically finding the network parameters that accurately reproduce biological motor sequences and their adaptation to multiple physiological inputs. In this way, we will have resolved the issue of programming analogue CPGs which has long been the obstacle to using neural chips in medicine. An adaptive pacemaker will be constructed, tested, validated and trialled on animal models of atrio-ventricular block and left bundle branch block to demonstrate the benefits of heart rate adaptation, beat-to-beat cardiac resynchronization and respiratory sinus arrhythmia. By providing novel therapy for arrhythmias, heart failure and their comorbidities such as sleep apnoea and hypertension, CResPace will extend patients’ life and increase quality of life.

 Deliverables

List of deliverables.
Report and publications on the benefits of restoring adaptive respiratory sinus arrhythmia in rodents with induced heart failure Documents, reports 2020-04-25 00:56:09
A database of electrophysiological recordings of respiratory neurons Other 2020-04-08 13:50:30
Universal VLSI circuit models for gate variables and gate recovery times Other 2020-04-08 13:50:30
A database of electrocardiograms, arterial O2, CO2, lung inflation and blood pressure time series recordings for dog and pigs in states ranging from rest to intense activity Documents, reports 2020-04-08 13:50:30
Model of the mammalian respiratory CPG Other 2020-04-08 13:50:30
Consortium website and logo Documents, reports 2020-04-08 13:50:30
Data management plan Documents, reports 2020-04-08 13:50:30

Take a look to the deliverables list in detail:  detailed list of CResPace deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Andreas Spannbauer, Denise Traxler, Dominika Lukovic, Katrin Zlabinger, Johannes Winkler, Alfred Gugerell, Péter Ferdinandy, Derek J. Hausenloy, Noemi Pavo, Maximilian Y. Emmert, Simon P. Hoerstrup, Andras Jakab, Mariann Gyöngyösi, Martin Riesenhuber
Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction
published pages: 2140, ISSN: 1422-0067, DOI: 10.3390/ijms20092140
International Journal of Molecular Sciences 20/9 2020-04-08
2019 Kamal Abu-Hassan, Joseph D. Taylor, Paul G. Morris, Elisa Donati, Zuner A. Bortolotto, Giacomo Indiveri, Julian F. R. Paton, Alain Nogaret
Optimal solid state neurons
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13177-3
Nature Communications 10/1 2020-04-08
2019 Erin L. O\'Callaghan, Renata M. Lataro, Eva L. Roloff, Ashok S. Chauhan, Helio C. Salgado, Edward Duncan, Alain Nogaret, Julian F. R. Paton
Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction
published pages: , ISSN: 0022-3751, DOI: 10.1113/jp277293
The Journal of Physiology 2020-04-08
2018 Alain Nogaret, Alastair King
Inhibition delay increases neural network capacity through Stirling transform
published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.97.030301
Physical Review E 97/3 2020-04-08

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The information about "CRESPACE" are provided by the European Opendata Portal: CORDIS opendata.

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