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B-SMART SIGNED

Brain-Specific, Modular and Active RNA Therapeutics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "B-SMART" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://b-smart-project.eu/
 Total cost 5˙998˙303 €
 EC max contribution 5˙998˙303 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2016-two-stage
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 861˙080.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 889˙151.00
3    VIB VZW BE (ZWIJNAARDE - GENT) participant 862˙812.00
4    ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI SPA IT (APRILIA) participant 691˙250.00
5    SINTEF AS NO (TRONDHEIM) participant 580˙773.00
6    MALVERN PANALYTICAL LIMITED UK (MALVERN) participant 571˙250.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 551˙375.00
8    EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE (ST INGBERT) participant 503˙750.00
9    20MED THERAPEUTICS BV NL (ENSCHEDE) participant 398˙125.00
10    STIFTELSEN SINTEF NO (TRONDHEIM) participant 88˙736.00

Map

 Project objective

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases.

I. To design modular nanoparticles consisting of o an active RNA payload o established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular vesicle-based) nanoparticles o a targeting ligand consisting of the variable domain of heavy chain only antibodies (also known as VHHs or nanobodies), which are coupled to the carrier platform

II. To manufacture the modular nanoparticles using a microfluidic assembly system that will ensure quality-by-design: uniform nanoparticles across research sites and excellent control over the physico-chemical parameters.

III. To test pre-clinical activity of formulations with promising in vitro activity with good cell/blood compatibility and to select the best RNA-formulation for clinical translation to treat neurodegenerative diseases. Pre-clinical efficacy is tested after o local injection o nasal administration o systemic administration The neurodegenerative diseases carry a high burden for patients since they are without exception progressive. But they also carry a substantial socio-economic burden with estimated costs of 130 billion euro. per year (2008).

IV. The technical work in B-SMART will be supported by project management. It ensures that the project is coordinated in a clear, unambiguous and mutually acceptable manner and that the project achieves its objectives, within the given financial and time constraints.

in B-SMART we expect to arrive at a scale-able nanoparticle formulation with uniform characteristics that shows strong pre-clinical evidence of therapeutic efficacy and is ready for clinical translation.

 Deliverables

List of deliverables.
B-SMART audio-visual material Websites, patent fillings, videos etc. 2020-02-12 10:13:10
Public project website Websites, patent fillings, videos etc. 2020-02-12 10:13:10

Take a look to the deliverables list in detail:  detailed list of B-SMART deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Helena Sork, Giulia Corso, Kaarel Krjutskov, Henrik J. Johansson, Joel Z. Nordin, Oscar P. B. Wiklander, Yi Xin Fiona Lee, Jakub Orzechowski Westholm, Janne Lehtiö, Matthew J. A. Wood, Imre Mäger, Samir EL Andaloussi
Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28485-9
Scientific Reports 8/1 2020-03-05
2018 Eleni Samaridou Martijn Evers, Pieter Vader, Raymond Schiffelers Evgenia Salta, Hannah Walgrave, Bart De Strooper María José Alonso
PEG-PGA Enveloped CPP-RNA nanocomplexes (ENCPs) for the nose-to-brain RNA delivery and treatment of neurodegenerative diseases
published pages: , ISSN: , DOI:
2018 Controlled Release Society (CRS) Annual Meeting 2020-03-05
2018 Martijn J. W. Evers, Jayesh A. Kulkarni, Roy van der Meel, Pieter R. Cullis, Pieter Vader, Raymond M. Schiffelers
State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery
published pages: 1700375, ISSN: 2366-9608, DOI: 10.1002/smtd.201700375
Small Methods 2020-02-12
2018 Eduard Willms, Carlos Cabañas, Imre Mäger, Matthew J. A. Wood, Pieter Vader
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00738
Frontiers in Immunology 9 2020-02-12
2017 Aisling J. O’Loughlin, Imre Mäger, Olivier G. de Jong, Miguel A. Varela, Raymond M. Schiffelers, Samir El Andaloussi, Matthew J.A. Wood, Pieter Vader
Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles
published pages: 1580-1587, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.03.021
Molecular Therapy 25/7 2020-02-12
2018 Eleni Samaridou, Maria José Alonso
Nose-to-brain peptide delivery – The potential of nanotechnology
published pages: 2888-2905, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.11.001
Bioorganic & Medicinal Chemistry 26/10 2020-02-12

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The information about "B-SMART" are provided by the European Opendata Portal: CORDIS opendata.

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