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iNanoBIT SIGNED

Integration of Nano- and Biotechnology for beta-cell and islet Transplantation

Total Cost €

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EC-Contrib. €

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Partnership

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 iNanoBIT project word cloud

Explore the words cloud of the iNanoBIT project. It provides you a very rough idea of what is the project "iNanoBIT" about.

coordinated    regenerative    technological    develop1    animal    nano    pancreatic    types    preclinical    marketing    perfect    tissue    points    scope    levels    pet    healthcare    differentiated    technologies    validated    beta    academic    medicinal    area    fast    porcinexenotransplant    stem    transplantable    translation    opening    engraftment    combination    therapies    competitiveness    body    multimodality    porcine    patients    function    human    trl6    imaging    islets    chain    vitro    proliferation    islet    spect    humans    survival    models    pluripotent    sensitivity    validate    subsequent    nanotechnologies    industrial    trials    toolbox    provision    clinical    cell    transplants    optoacoustic    reinforce    sensitive    ready    nanotechnology    safe    vital    starting    cells    sme    nanomolecules    molecule    cellular    mr    market    missing    arrive    translational    match    vivo    model    trl    supply    inanobit    supplies    excellent    monitoring   

Project "iNanoBIT" data sheet

The following table provides information about the project.

Coordinator
BIOTALENTUM TUDASFEJLESZTO KFT 

Organization address
address: AULICH LAJOS UTCA 26
city: GOEDOELLO
postcode: 2100
website: www.biotalentum.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Project website http://inanobit.eu/
 Total cost 6˙999˙997 €
 EC max contribution 6˙999˙997 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOTALENTUM TUDASFEJLESZTO KFT HU (GOEDOELLO) coordinator 1˙301˙341.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 1˙629˙575.00
3    Mediso Orvosi Berendezes Fejleszto es Szerviz Kft. HU (BUDAPEST) participant 795˙375.00
4    BBS NANOTECHNOLOGIA KUTATASI ES FEJLESZTESI KORLATOLT FELELOSSEGU TARSASAG HU (DEBRECEN) participant 710˙726.00
5    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA IT (MILANO) participant 652˙563.00
6    DEFYMED FR (STRASBOURG) participant 645˙625.00
7    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 636˙041.00
8    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 628˙750.00

Map

 Project objective

The iNanoBIT project is aimed to apply nanotechnologies for imaging porcine pancreatic islet cellular transplants and induced pluripotent stem cell-derived beta-cells and subsequent regenerative processes in vivo in a porcine model. The project will develop1) novel highly sensitive nanotechnology-based imaging approaches allowing for monitoring of survival, engraftment, proliferation, function and whole body distribution of the cellular transplants in a preclinical porcine model with excellent translational potential to humans; 2) develop and validate the application of state-of-the-art imaging technologies facilitating the provision of new regenerative therapies to preclinical large animal models and patients; 3) directly contribute to the opening of a new market sector for i) imaging equipment (SPECT, PET/MR, optoacoustic imaging in preclinical large animal models and patients), ii) nano-imaging molecule supplies (nanomolecules allowing multimodality imaging of specific cell types with high sensitivity), iii) validated transplantable in vitro differentiated human beta-cells and porcinexenotransplant islets thus will reinforce the European healthcare supply chain for regenerative medicinal products. The iNanoBIT project will provide the currently missing toolbox for preclinical/clinical testing for a safe translation of regenerative medicinal cellular and tissue products, currently under preclinical and clinical trials, which is vital for the competitiveness of the European healthcare sector in this fast-growing area. The consortium of 5 SME and 3 Academic partners is coordinated and driven by the industrial partners from the field of nanotechnology, imaging and stem cell technologies, providing a perfect match and unique combination addressing the scope and expected impact of the call and providing TRL 3/4 starting points for the key technological elements, and expect to arrive to TRL6 levels of validated technologies ready for marketing by the end of the project.

 Publications

year authors and title journal last update
List of publications.
2018 Elisabeth Kemter, Eckhard Wolf
Recent progress in porcine islet isolation, culture and engraftment strategies for xenotransplantation
published pages: 1, ISSN: 1087-2418, DOI: 10.1097/mot.0000000000000579
Current Opinion in Organ Transplantation 2019-10-30
2018 Elisabeth Kemter, Joachim Denner, Eckhard Wolf
Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic?
published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-018-1074-5
Current Diabetes Reports 18/11 2019-10-30
2019 Susanna Sampaolesi, Francesco Nicotra, Laura Russo
Glycans in nanomedicine, impact and perspectives
published pages: 43-60, ISSN: 1756-8919, DOI: 10.4155/fmc-2018-0368
Future Medicinal Chemistry 11/1 2019-10-30

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The information about "INANOBIT" are provided by the European Opendata Portal: CORDIS opendata.

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