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nTRACK SIGNED

Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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Project "nTRACK" data sheet

The following table provides information about the project.

Coordinator
ACONDICIONAMIENTO TARRASENSE ASSOCIACION 

Organization address
address: CARRER DE LA INNOVACIO 2
city: TERRASSA
postcode: 08225
website: www.leitat.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 6˙907˙615 €
 EC max contribution 6˙863˙864 € (99%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme /RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACONDICIONAMIENTO TARRASENSE ASSOCIACION ES (TERRASSA) coordinator 1˙415˙437.00
2    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 1˙019˙687.00
3    BAR ILAN UNIVERSITY IL (RAMAT GAN) participant 787˙356.00
4    UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE (Mainz) participant 631˙588.00
5    TECHNOLOGIKES LYSEIS BIOEKPOBIS IKE EL (ATHINA) participant 563˙568.00
6    PLURISTEM LTD IL (HAIFA) participant 487˙500.00
7    VIVOTECNIA RESEARCH SL ES (TRES CANTOS - MADRID) participant 454˙681.00
8    MJR PHARMJET GMBH DE (UBERHERRM) participant 436˙871.00
9    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) participant 325˙068.00
10    ASPHALION SL ES (BARCELONA) participant 305˙732.00
11    RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU NL (BILTHOVEN) participant 269˙747.00
12    CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD UK (Cambridge) participant 166˙625.00

Mappa

 Project objective

Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments. The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment. The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "NTRACK" are provided by the European Opendata Portal: CORDIS opendata.

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