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nTRACK SIGNED

Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

nTRACK project word cloud

Explore the words cloud of the nTRACK project. It provides you a very rough idea of what is the project "nTRACK" about.

manufacturing cellular scaled formal predictive efficacy noninvasive regulatory disease weakness muscular agent sheep nps patterns relies pet safe size ct series prompt multimodal mri earlier hospital synthesis safety clinically migration therapy infrastructure ntrack symptoms therapies sensitive imaging biodistribution labeling lack effectiveness good injury follow substantially trials nanoimaging offers diseases cells quantitative progression cell body evaluation fits gmp predict longitudinal combination treatment tracking nanoparticles time transplanted stages prognosis viability tools personalised model treatments demonstrated introduction modalities interactions clinical stem settings transform

Project "nTRACK" data sheet

The following table provides information about the project.

Coordinator	ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.n-track.eu
Total cost	6˙907˙615 €
EC max contribution	6˙863˙864 € (99%)
Programme	1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-2017-two-stage
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACONDICIONAMIENTO TARRASENSE ASSOCIACION ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TERRASSA)	coordinator	1˙415˙437.00
2	FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Organization address address: PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA city: BARCELONA postcode: 8035 website: http://www.vhir.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	1˙019˙687.00
3	BAR ILAN UNIVERSITY BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	participant	787˙356.00
4	UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Organization address address: Langenbeckstrasse 1 city: Mainz postcode: 55131 website: http://www.um-mainz.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Mainz)	participant	631˙588.00
5	BIOEMISSION TECHNOLOGY SOLUTIONS IKE BIOEMISSION TECHNOLOGY SOLUTIONS IKE Organization address address: ALEXANDRAS AVENUE 116 city: ATHINA postcode: 114 72 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	563˙568.00
6	PLURISTEM LTD PLURISTEM LTD Organization address address: MATAM INDUSTRIAL PARK BLDG 20 city: HAIFA postcode: 31905 website: http://www.pluristem.com/index.asp contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HAIFA)	participant	487˙500.00
7	VIVOTECNIA RESEARCH SL VIVOTECNIA RESEARCH SL Organization address address: CALLE SANTIAGO GRISOLIA 2 city: TRES CANTOS - MADRID postcode: 28760 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TRES CANTOS - MADRID)	participant	454˙681.00
8	MJR PHARMJET GMBH MJR PHARMJET GMBH Organization address address: INDUSTRIESTRASSE 1B city: UBERHERRM postcode: 66802 website: www.mjr-pharmjet.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (UBERHERRM)	participant	436˙871.00
9	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AGIA PARASKEVI)	participant	325˙068.00
10	ASPHALION SL ASPHALION SL Organization address address: CALLE TARRAGONA, NUMEROS 151-157, PLANTA 10, BLOQU city: BARCELONA postcode: 8014 website: www.asphalion.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	305˙732.00
11	RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA website: www.rivm.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	269˙747.00
12	CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD CAMBRIDGE NANOMATERIALS TECHNOLOGY LTD Organization address address: ORCHARD WAY, LOWER CAMBOURNE 14 city: Cambridge postcode: CB23 5BN website: www.cnt-ltd.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cambridge)	participant	166˙625.00

Map

Project objective

Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments. The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment. The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow the prompt introduction into clinical trials after the end of the project.

Publications

List of publications.
year	authors and title	journal	last update
2019	Menachem Motiei, Tamar Dreifuss, Tamar Sadan, Noam Omer, Tamar Blumenfeld-Katzir, Eirini Fragogeorgi, George Loudos, Rachela Popovtzer, Noam Ben-Eliezer Trimodal Nanoparticle Contrast Agent for CT, MRI and SPECT Imaging: Synthesis and Characterization of Radiolabeled Core/Shell Iron Oxide@Gold Nanoparticles published pages: 291-294, ISSN: 0366-7022, DOI: 10.1246/cl.180780	Chemistry Letters 48/3	2020-04-15

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