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Targeting Innate Lymphoid Cells

Total Cost €


EC-Contrib. €






Project "TILC" data sheet

The following table provides information about the project.


Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 2˙500˙000.00


 Project objective

TILC focuses on Innate Lymphoid Cells (ILCs). ILCs are a newly discovered type of lymphocyte, and their study opens up new perspectives for understanding and manipulating of immunity. ILCs include cytotoxic ILCs (NK cells) and helper-like ILCs (ILC1, ILC2 & ILC3). Studies of ILC2 cells have advanced considerably, but much remains unknown about the respective roles of NK, ILC1 and ILC3 cells. TILC aims to explore new frontiers in ILC biology, by focusing on these subsets of ILCs in mice and humans, through five specific aims. 1. NK cells, ILC1 & NCRILC3 are known to express NKp46 in humans and mice, but the nature of the NKp46 ligands remains unclear, limiting our understanding of the biology of these three major ILC subsets. We thus aim to identify the NKp46 ligands, building on our preliminary data showing that Complement Factor P (CFP, Properdin) is involved in NKp46 recognition, hence revealing an unprecedented mode of immune recognition. 2. We also aim to create new mouse models selectively targeting these ILC subsets in vivo. We will then use these models for dissecting out the selective roles of ILC subsets in two major immune functions: cancer surveillance and gut homeostasis. 3. In cancer, we will investigate the contribution of these cells to tumor editing. 4. In the intestine, we will focus on the homeostasis of the cecum and appendix. These organs were long considered to be vestiges of evolution, but our own recent findings and those of phylogenetic studies have challenged this notion. We thus aim to address the role of ILC subsets in the cecum/appendix, and determine whether these organs serve as a refuge for repopulation with commensals after dysbiosis. 5. Finally, we aim to identify patients with deficiencies in ILCs, to dissect the function of these cells in natura. From the molecular scale to that of patients, we believe that TILC will provide answers to some of the most pressing questions concerning the role and clinical potential of NKp46 ILCs


year authors and title journal last update
List of publications.
2019 Thorbald van Hall, Pascale André, Amir Horowitz, Dan Fu Ruan, Linda Borst, Robert Zerbib, Emilie Narni-Mancinelli, Sjoerd H. van der Burg, Eric Vivier
Monalizumab: inhibiting the novel immune checkpoint NKG2A
published pages: , ISSN: 2051-1426, DOI: 10.1186/s40425-019-0761-3
Journal for ImmunoTherapy of Cancer 7/1 2020-04-15
2018 Laura Chiossone, Eric Vivier
Nouvelles frontières de la lutte contre le cancer
published pages: 61-67, ISSN: 2105-0678, DOI: 10.1051/jbio/2019011
Biologie Aujourd\'hui 212/3-4 2020-04-15
2019 Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF
published pages: 2010-2023, ISSN: 0022-1007, DOI: 10.1084/jem.20182164
Journal of Experimental Medicine 216/9 2020-04-15
2018 Linda Quatrini, Elisabeth Wieduwild, Bertrand Escaliere, Jessica Filtjens, Lionel Chasson, Caroline Laprie, Eric Vivier, Sophie Ugolini
Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells
published pages: 954-962, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0185-0
Nature Immunology 19/9 2019-09-09
2018 Francisca F. Almeida, Sara Tognarelli, Antoine Marçais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zöller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G.
A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets
published pages: e1475875, ISSN: 2162-402X, DOI: 10.1080/2162402x.2018.1475875
OncoImmunology 7/10 2019-09-09
2018 Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, Mark J Smyth, James McCarthy, Chri
Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection
published pages: e1003, ISSN: 2050-0068, DOI: 10.1002/cti2.1003
Clinical & Translational Immunology 7/1 2019-09-09
2019 Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09431-3
Nature Communications 10/1 2019-08-29
2018 Pascale André, Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu Bléry, Cécile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, Jérôme Fayette, Agnès Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadiall
Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells
published pages: 1731-1743.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.014
Cell 175/7 2019-08-29
2018 Linda Quatrini, Eric Vivier, Sophie Ugolini
Neuroendocrine regulation of innate lymphoid cells
published pages: 120-136, ISSN: 0105-2896, DOI: 10.1111/imr.12707
Immunological Reviews 286/1 2019-08-29
2019 Adeline Crinier, Eric Vivier, Mathieu Bléry
Helper-like innate lymphoid cells and cancer immunotherapy
published pages: 101274, ISSN: 1044-5323, DOI: 10.1016/j.smim.2019.04.002
Seminars in Immunology 2019-08-29
2018 Adeline Crinier, Pierre Milpied, Bertrand Escalière, Christelle Piperoglou, Justine Galluso, Anaïs Balsamo, Lionel Spinelli, Inaki Cervera-Marzal, Mikaël Ebbo, Mathilde Girard-Madoux, Sébastien Jaeger, Emilie Bollon, Sami Hamed, Jean Hardwigsen, Sophie Ugolini, Frédéric Vély, Emilie Narni-Mancinelli, Eric Vivier
High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice
published pages: 971-986.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.09.009
Immunity 49/5 2019-08-29
2018 Giorgia Rota, Charlène Niogret, Anh Thu Dang, Cristina Ramon Barros, Nicolas Pierre Fonta, Francesca Alfei, Leonor Morgado, Dietmar Zehn, Walter Birchmeier, Eric Vivier, Greta Guarda
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
published pages: 39-49, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.03.026
Cell Reports 23/1 2019-06-13
2017 Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deghmane, Benjamin Rossi, Patrick Fourquet, Bertrand Escalière, Yann M. Kerdiles, Sophie Ugolini, Muhamed-Kheir Taha, Eric Vivier
Complement factor P is a ligand for the natural killer cell–activating receptor NKp46
published pages: eaam9628, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aam9628
Science Immunology 2/10 2019-06-13
2018 Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, Gérard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N.J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits
Innate Lymphoid Cells: 10 Years On
published pages: 1054-1066, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.07.017
Cell 174/5 2019-06-13
2019 Laurent Gauthier, Ariane Morel, Nadia Anceriz, Benjamin Rossi, Audrey Blanchard-Alvarez, Gwendoline Grondin, Sylvia Trichard, Cédric Cesari, Melody Sapet, Frédéric Bosco, Hélène Rispaud-Blanc, Franceline Guillot, Stéphanie Cornen, Alain Roussel, Béatrice Amigues, Guillaume Habif, Flavien Caraguel, Sandrine Arrufat, Romain Remark, François Romagné, Yannis Morel, Emilie Narni-Mancinelli, Er
Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity
published pages: 1701-1713.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.041
Cell 177/7 2019-09-05
2018 Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne, Eric Vivier
Natural killer cells and other innate lymphoid cells in cancer
published pages: 671-688, ISSN: 1474-1733, DOI: 10.1038/s41577-018-0061-z
Nature Reviews Immunology 18/11 2019-09-05
2018 Mathilde J.H. Girard-Madoux, Mercedes Gomez de Agüero, Stephanie C. Ganal-Vonarburg, Catherine Mooser, Gabrielle T. Belz, Andrew J. Macpherson, Eric Vivier
The immunological functions of the Appendix: An example of redundancy?
published pages: 31-44, ISSN: 1044-5323, DOI: 10.1016/j.smim.2018.02.005
Seminars in Immunology 36 2019-09-05

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