Explore the words cloud of the HiChemSynPro project. It provides you a very rough idea of what is the project "HiChemSynPro" about.
The following table provides information about the project.
CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION
|Coordinator Country||France [FR]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION||FR (STRASBOURG)||coordinator||1˙500˙000.00|
Chemical protein synthesis is an indispensable method in chemical and synthetic biology. However, at the present moment, it is laborious and involves multiple optimization and purification steps. High-throughput approaches for total synthesis of combinatorial libraries of custom-modified protein variants are needed. To change the situation, the work will be carried out in two directions: (1) implementation of microfluidic techniques for automation, miniaturization and multiplexing of experimental steps involved in the total synthesis of proteins, and (2) design and synthesis of novel catalytic proteins for efficient enzyme-assisted peptide ligations under denatured conditions. This innovative research technology will allow robust chemical synthesis of protein libraries with (100–10,000)-compounds with natural and unnatural modifications, bearing variety of post-translational modifications and also protein-like biopolymers. In this project, the new methodology will be validated by chemical synthesis of library of phosphorylated analogues of high mobility group protein A (HMGA), which is involved in gene-transcription and cancer development. Other potential future applications include protein design, biological problems where post-translational modifications play a crucial role (ranging from the ‘histone code’ hypothesis to understanding long-term memory) and functional annotation of newly discovered genes.
|year||authors and title||journal||last update|
RÃ©gis Boehringer, Bruno Kieffer, Vladimir Torbeev
Total chemical synthesis and biophysical properties of a designed soluble 24 kDa amyloid analogue
published pages: 5594-5599, ISSN: 2041-6520, DOI: 10.1039/c8sc01790e
|Chemical Science 9/25||2019-10-29|
Abhishek Baral, Aromal Asokan, Valentin Bauer, Bruno Kieffer, Vladimir Torbeev
Chemical synthesis of transactivation domain (TAD) of tumor suppressor protein p53 by native chemical ligation of three peptide segments
published pages: 703-708, ISSN: 0040-4020, DOI: 10.1016/j.tet.2018.11.074
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The information about "HICHEMSYNPRO" are provided by the European Opendata Portal: CORDIS opendata.
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