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CUPIDO SIGNED

Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CUPIDO" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.cupidoproject.eu
 Total cost 6˙094˙781 €
 EC max contribution 6˙094˙781 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2016-two-stage
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 1˙800˙141.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 689˙983.00
3    FIN-CERAMICA FAENZA SPA IT (FAENZA) participant 490˙000.00
4    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 484˙585.00
5    SIMULA RESEARCH LABORATORY AS NO (FORNEBU) participant 442˙338.00
6    NEMERA LA VERPILLIERE FR (LA VERPILLIERE) participant 400˙000.00
7    BIOEMISSION TECHNOLOGY SOLUTIONS IKE EL (ATHINA) participant 351˙750.00
8    CAMBRIDGE INNOVATION TECHNOLOGIES CONSULTING LIMITED UK (CAMBRIDGE) participant 314˙913.00
9    L.I.F.E. ITALIA SRL IT (MILANO) participant 300˙875.00
10    IN SRL IT (UDINE) participant 300˙285.00
11    PLUMESTARS SRL IT (PARMA PR) participant 300˙000.00
12    SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT FR (Chilly Mazarin) participant 219˙908.00
13    LIFE CORPORATION SA LU (LUXEMBOURG) participant 0.00

Map

 Project objective

The incidence of Cardiovascular Disease (CD) claims worldwide 17.1 million lives a year, with an estimated 31% of all deaths globally and a EU cost of 139 billion euros. Up to 40% of all deaths occur among the elderly. In spite of all medical efforts, the 5-year mortality was reduced significantly less than that of malignant diseases. This highlights the urgent need to overcome the difficulties associated with present pharmacological therapies (i.e. drug instability, and unspecific targeting) by developing new ground-breaking therapeutic strategies that go far beyond any current regimens. New approaches for safe, efficient, and heart-specific delivery of therapeutics are strongly required. CUPIDO is envisioned to meet these critical needs by providing an unconventional and effective strategy based on nanoparticle-assisted delivery of clinically available and novel therapeutics to the diseased heart. In particular, CUPIDO will develop innovative bioinspired hybrid nanoparticles formulated as biologicals delivery, which are i) biocompatible and biodegradable, ii) designed for crossing biological barriers, and iii) guidable to the heart. A combination of multidisciplinary manufacturing and validation approaches will be employed, bringing the envisioned product beyond the currently available clinical and day-to-day management of CD individuals. Scale-up production, and respect of medical regulatory requirements will allow CUPIDO to deliver a final product for future late pre-clinical and clinical studies. Altogether, CUPIDO will foster the translation of nanomedical applications toward the cardiac field, which although still in its start, offers great potential to overcome the limitations associated to the currently pharmacological treatments.

 Deliverables

List of deliverables.
Extended model, describing relationship between FeCaPs and deposition site when exposed to an external magnetic field (M12) Documents, reports 2020-04-08 11:30:38
Distribution of electromagnetic fields in the target area due to the drug targeting systems Documents, reports 2020-04-08 11:30:37
Visual identity kit (M12) Documents, reports 2020-04-08 11:30:38
In vivo assessment of the studied nanopartilces using different imaging modalities (M12) Documents, reports 2020-04-08 11:30:38
Summary of annual workshops and networking events building communities (M12) Documents, reports 2020-04-08 11:30:38
Web portal, social media Documents, reports 2020-04-08 11:30:38
Press releases (M3) Documents, reports 2020-04-08 11:30:38
In vitro assessment of nanoparticle behavior at/across the pulmonary barrier (M12) Documents, reports 2020-04-08 11:30:38
Extension of open-source flow simulation framework to also include porous media flow. Establish relationship between different nanoparticles and deposition sites in both small and large animal models (M18) Documents, reports 2020-04-08 11:30:37
Summary of annual workshops and networking events building communities (M18) Documents, reports 2020-04-08 11:30:38
Aptamer-mediated guidance of CaP (M12) Documents, reports 2020-04-08 11:30:38
Press releases (M12) Documents, reports 2020-04-08 11:30:38
Functional assessment (compatibility, physic-chemical and biological stability) of CaP restoration and drug release Documents, reports 2020-04-08 11:30:37
E-newsletter (M12) Documents, reports 2020-04-08 11:30:38
EMD-mediated guidance of FeCaP (M12) Documents, reports 2020-04-08 11:30:38

Take a look to the deliverables list in detail:  detailed list of CUPIDO deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Alessandra Marrella, Michele Iafisco, Alessio Adamiano, Stefano Rossi, Maurizio Aiello, Maria Barandalla-Sobrados, Pierluigi Carullo, Michele Miragoli, Anna Tampieri, Silvia Scaglione, Daniele Catalucci
A combined low-frequency electromagnetic and fluidic stimulation for a controlled drug release from superparamagnetic calcium phosphate nanoparticles: potential application for cardiovascular diseases
published pages: 20180236, ISSN: 1742-5689, DOI: 10.1098/rsif.2018.0236
Journal of The Royal Society Interface 15/144 2020-04-08
2018 Lorenzo Degli Esposti, Francesca Carella, Alessio Adamiano, Anna Tampieri, Michele Iafisco
Calcium phosphate-based nanosystems for advanced targeted nanomedicine
published pages: 1223-1238, ISSN: 0363-9045, DOI: 10.1080/03639045.2018.1451879
Drug Development and Industrial Pharmacy 44/8 2020-04-08
2018 Michele Miragoli, Paola Ceriotti, Michele Iafisco, Marco Vacchiano, Nicolò Salvarani, Alessio Alogna, Pierluigi Carullo, Gloria Belén Ramirez-Rodríguez, Tatiana Patrício, Lorenzo Degli Esposti, Francesca Rossi, Francesca Ravanetti, Silvana Pinelli, Rossella Alinovi, Marco Erreni, Stefano Rossi, Gianluigi Condorelli, Heiner Post, Anna Tampieri, Daniele Catalucci
Inhalation of peptide-loaded nanoparticles improves heart failure
published pages: eaan6205, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aan6205
Science Translational Medicine 10/424 2020-04-08
2017 Lorenzo Fassina, Giacomo Rozzi, Stefano Rossi, Simone Scacchi, Maricla Galetti, Francesco Paolo Lo Muzio, Fabrizio Del Bianco, Piero Colli Franzone, Giuseppe Petrilli, Giuseppe Faggian, Michele Miragoli
Cardiac kinematic parameters computed from video of in situ beating heart
published pages: 46143, ISSN: 2045-2322, DOI: 10.1038/srep46143
Scientific Reports 7 2020-04-08
2018 Vittoria Di Mauro, Maria Barandalla-Sobrados, Daniele Catalucci
The noncoding-RNA landscape in cardiovascular health and disease
published pages: , ISSN: 2468-0540, DOI: 10.1016/j.ncrna.2018.02.001
Non-coding RNA Research 2020-04-08

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