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EVALVE SIGNED

Biomechanics and signaling in models of congenital heart valve defects

Total Cost €

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EC-Contrib. €

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Partnership

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 EVALVE project word cloud

Explore the words cloud of the EVALVE project. It provides you a very rough idea of what is the project "EVALVE" about.

integrate    critical    chip    function    fetal    physiology    mediated    combined    structures    endocardial    adulthood    made    re    cell    heart    normally    network    molecular    light    matrix    throughput    directed    modeling    optical    human    elucidation    microscopy    functional    expression    explored    pathological    understand    unraveling    lifetime    form    cells    resolution    beats    abnormal    mechanotransduction    either    mechanosensors    little    gene    mathematical    components    repair    congenital    aberrant    extracellular    pioneered    body    challenged    forces    cardiovascular    times    origins    lineage    interventions    transcriptional    morphogenesis    mrna    valve    hemodynamic    biological    lab    links    programs    reporters    feedback    subcellular    therapeutic    shed    amongst    developmental    endothelial    mechanosensitivity    quantify    stress    cardiac    organize    signs    mechanical    quiescent    activated    modulate    tweezing    biomechanical    mechanically    embryogenesis    fundamental    defects    mechanism    loops    roles    interactions    valves    3d    sequencing    edcs    billion    live    diseases   

Project "EVALVE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.igbmc.fr/research/department/1/team/15/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 798˙871.00
2    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 1˙201˙128.00

Map

 Project objective

Mechanical forces are fundamental to cardiovascular development and physiology. The interactions between mechanical forces and endothelial cells are mediated by mechanotransduction feedback loops. My lab is interested in understanding how hemodynamic forces modulate cardiovascular function and morphogenesis. Overall, our recent work is unraveling the biological links between mechanical forces, mechanotransduction and endothelial cell responses. The heart beats 2.6 billion times in a human lifetime and heart valves are amongst the most mechanically challenged structures of the body. The cardiac valves are made of endocardial cells (EdCs) and extracellular matrix components. Most valve diseases have their origins in embryogenesis, either as signs of abnormal developmental processes or the aberrant re-expression of fetal gene programs normally quiescent in adulthood.

This project is directed towards the elucidation of the biomechanical mechanism of mechanotransduction at the subcellular and molecular level and in addressing how EdCs integrate this information to form and maintain a functional cardiac valve. We will identify the mechanosensors at work in EdCs and their roles during cardiac valve development and repair. To do so, we will implement unique optical methodologies the lab has pioneered to characterize endocardial mechanotransduction: 1) Optical tweezing combined with mechanical stress reporters to test the mechanosensitivity of EdCs; 2) High resolution live microscopy and mathematical modeling to quantify mechanical forces; 3) 3D cell lineage studies to understand how cells respond and organize during pathological valve development. We will also use high-throughput mRNA- and ChIP-sequencing to characterize the transcriptional network activated by forces.

When completed this proposal will shed light on a critical, but little explored, aspect of congenital valve defects and will be useful for identifying new targets for therapeutic interventions.

 Publications

year authors and title journal last update
List of publications.
2017 Renee Wei-Yan Chow, Julien Vermot
The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology
published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1
F1000Research 6 2020-01-29
2017 Renee Wei-Yan Chow, Julien Vermot
The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology
published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1
F1000Research 6 2020-01-29
2018 Renee Wei-Yan Chow, Paola Lamperti, Emily Steed, Francesco Boselli, Julien Vermot
Following Endocardial Tissue Movements via Cell Photoconversion in the Zebrafish Embryo
published pages: , ISSN: 1940-087X, DOI: 10.3791/57290
Journal of Visualized Experiments 132 2020-01-29
2017 Lauren M. Goddard, Anne-Laure Duchemin, Harini Ramalingan, Bingruo Wu, Mei Chen, Sharika Bamezai, Jisheng Yang, Li Li, Michael P. Morley, Tao Wang, Marielle Scherrer-Crosbie, David B. Frank, Kurt A. Engleka, Stephen C. Jameson, Edward E. Morrisey, Thomas J. Carroll, Bin Zhou, Julien Vermot, Mark L. Kahn
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis
published pages: 274-289.e5, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.09.023
Developmental Cell 43/3 2020-01-29
2019 Rita R. Ferreira, Hajime Fukui, Renee Chow, Andrej Vilfan, Julien Vermot
The cilium as a force sensor−myth versus reality
published pages: jcs213496, ISSN: 0021-9533, DOI: 10.1242/jcs.213496
Journal of Cell Science 132/14 2020-01-29
2018 Rita R. Ferreira, Guillaume Pakula, Lhéanna Klaeyle, Hajime Fukui, Andrej Vilfan, Willy Supatto, Julien Vermot
Chiral Cilia Orientation in the Left-Right Organizer
published pages: 2008-2016.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.10.069
Cell Reports 25/8 2020-01-29
2018 Pedro Campinho, Paola Lamperti, Francesco Boselli, Julien Vermot
Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry
published pages: 20170332, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0332
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1759 2020-01-29

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