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EVALVE SIGNED

Biomechanics and signaling in models of congenital heart valve defects

Total Cost €

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EC-Contrib. €

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Partnership

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 EVALVE project word cloud

Explore the words cloud of the EVALVE project. It provides you a very rough idea of what is the project "EVALVE" about.

lab    lineage    interactions    challenged    biological    gene    re    signs    loops    network    live    fetal    therapeutic    body    fundamental    valves    mathematical    stress    programs    biomechanical    abnormal    integrate    forces    mechanosensors    endocardial    interventions    edcs    mechanism    roles    molecular    diseases    organize    transcriptional    chip    normally    sequencing    modulate    activated    combined    function    light    billion    explored    repair    microscopy    quiescent    mrna    3d    origins    physiology    mechanically    cell    morphogenesis    optical    cells    functional    quantify    feedback    cardiovascular    tweezing    resolution    heart    subcellular    expression    valve    made    either    links    cardiac    congenital    endothelial    shed    reporters    amongst    human    lifetime    hemodynamic    components    matrix    throughput    mechanical    pioneered    mediated    aberrant    times    elucidation    critical    mechanosensitivity    little    pathological    directed    structures    adulthood    form    understand    unraveling    defects    developmental    beats    modeling    extracellular    embryogenesis    mechanotransduction   

Project "EVALVE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.igbmc.fr/research/department/1/team/15/
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 798˙871.00
2    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 1˙201˙128.00

Map

 Project objective

Mechanical forces are fundamental to cardiovascular development and physiology. The interactions between mechanical forces and endothelial cells are mediated by mechanotransduction feedback loops. My lab is interested in understanding how hemodynamic forces modulate cardiovascular function and morphogenesis. Overall, our recent work is unraveling the biological links between mechanical forces, mechanotransduction and endothelial cell responses. The heart beats 2.6 billion times in a human lifetime and heart valves are amongst the most mechanically challenged structures of the body. The cardiac valves are made of endocardial cells (EdCs) and extracellular matrix components. Most valve diseases have their origins in embryogenesis, either as signs of abnormal developmental processes or the aberrant re-expression of fetal gene programs normally quiescent in adulthood.

This project is directed towards the elucidation of the biomechanical mechanism of mechanotransduction at the subcellular and molecular level and in addressing how EdCs integrate this information to form and maintain a functional cardiac valve. We will identify the mechanosensors at work in EdCs and their roles during cardiac valve development and repair. To do so, we will implement unique optical methodologies the lab has pioneered to characterize endocardial mechanotransduction: 1) Optical tweezing combined with mechanical stress reporters to test the mechanosensitivity of EdCs; 2) High resolution live microscopy and mathematical modeling to quantify mechanical forces; 3) 3D cell lineage studies to understand how cells respond and organize during pathological valve development. We will also use high-throughput mRNA- and ChIP-sequencing to characterize the transcriptional network activated by forces.

When completed this proposal will shed light on a critical, but little explored, aspect of congenital valve defects and will be useful for identifying new targets for therapeutic interventions.

 Publications

year authors and title journal last update
List of publications.
2017 Renee Wei-Yan Chow, Julien Vermot
The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology
published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1
F1000Research 6 2020-01-29
2017 Renee Wei-Yan Chow, Julien Vermot
The rise of photoresponsive protein technologies applications in vivo: a spotlight on zebrafish developmental and cell biology
published pages: 459, ISSN: 2046-1402, DOI: 10.12688/f1000research.10617.1
F1000Research 6 2020-01-29
2018 Renee Wei-Yan Chow, Paola Lamperti, Emily Steed, Francesco Boselli, Julien Vermot
Following Endocardial Tissue Movements via Cell Photoconversion in the Zebrafish Embryo
published pages: , ISSN: 1940-087X, DOI: 10.3791/57290
Journal of Visualized Experiments 132 2020-01-29
2017 Lauren M. Goddard, Anne-Laure Duchemin, Harini Ramalingan, Bingruo Wu, Mei Chen, Sharika Bamezai, Jisheng Yang, Li Li, Michael P. Morley, Tao Wang, Marielle Scherrer-Crosbie, David B. Frank, Kurt A. Engleka, Stephen C. Jameson, Edward E. Morrisey, Thomas J. Carroll, Bin Zhou, Julien Vermot, Mark L. Kahn
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis
published pages: 274-289.e5, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.09.023
Developmental Cell 43/3 2020-01-29
2019 Rita R. Ferreira, Hajime Fukui, Renee Chow, Andrej Vilfan, Julien Vermot
The cilium as a force sensor−myth versus reality
published pages: jcs213496, ISSN: 0021-9533, DOI: 10.1242/jcs.213496
Journal of Cell Science 132/14 2020-01-29
2018 Rita R. Ferreira, Guillaume Pakula, Lhéanna Klaeyle, Hajime Fukui, Andrej Vilfan, Willy Supatto, Julien Vermot
Chiral Cilia Orientation in the Left-Right Organizer
published pages: 2008-2016.e4, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.10.069
Cell Reports 25/8 2020-01-29
2018 Pedro Campinho, Paola Lamperti, Francesco Boselli, Julien Vermot
Three-dimensional microscopy and image analysis methodology for mapping and quantification of nuclear positions in tissues with approximate cylindrical geometry
published pages: 20170332, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0332
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1759 2020-01-29

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