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Precision Multi-Spectral Optoacoustic Tomography for Discovery Diagnosis and Intervention

Total Cost €


EC-Contrib. €






 PREMSOT project word cloud

Explore the words cloud of the PREMSOT project. It provides you a very rough idea of what is the project "PREMSOT" about.

post    spin    human    portable    international    gt    safe    observations    medical    sensitivity    free    contrast    relate    innovation    morphology    commercialized    awards    independent    limitations    ionizing    energy    2011    quantification    interventional    label    remaining    publications    premsot    grant    laboratories    erc    modality    tissue    images    north    germany    ithera    sepsis    placed    quantitative    multispectral    hypoxia    personalized    genomic    hybrid    2014    inflammation    award    guidance    bedside    surgery    diagnostics    discovery    unmet    neurology    uniquely    performance    american    longitudinal    ambulatory    2008    time    metrics    yielded    micro    modalities    tomography    world    function    asian    small    clinical    110    vascular    precision    pathophysiology    oxygenation    care    humans    introduce    metabolism    theory    off    unprecedented    hardware    animal    mode    biomarkers    validate    optoacoustic    ultrasound    disease    msot    exploratory    imaging    peer    optical    accuracy    medicine   

Project "PREMSOT" data sheet

The following table provides information about the project.


Organization address
postcode: 85764

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙497˙268 €
 EC max contribution 2˙497˙268 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The 2008 ERC Advanced Grant multispectral optoacoustic tomography (MSOT) yielded a novel modality for post-genomic small animal optical imaging, >110 peer-reviewed publications and several major awards including the 2014 Germany’s Innovation award. Since 2011 spin-off iThera Medical GmbH commercialized and placed MSOT systems in European, Asian and North American laboratories, making MSOT an international term. MSOT brought unprecedented optical imaging performance now enabling independent discovery and publications from researchers throughout the world. Compared to other imaging modalities, MSOT uniquely images tissue oxygenation and other vascular and pathophysiology parameters in label-free and portable mode, using safe non-ionizing energy. Therefore, MSOT can impact real-time interventional guidance and longitudinal vascular diagnostics and enable a next level of discovery based on quantitative observations in humans, within the novel requirements of precision and personalized medicine. PREMSOT considers the next steps in the MSOT development and will ❶ design and develop label-free portable hybrid MSOT and ultrasound imaging (US) for human use, ❷ research novel theory and hardware to address remaining MSOT limitations and improve the sensitivity and quantification accuracy, a necessary step for improving MSOT precision, ❸ i) validate quantitative MSOT imaging of tissue oxygenation and hypoxia, (micro)-vascular morphology and function, ii) research label-free imaging of inflammation and metabolism and iii) relate MSOT contrast to tissue and disease pathophysiology metrics and ❹ introduce label-free MSOT/US to discovery and clinical care. MSOT contrast features will be investigated as biomarkers in vascular medicine and surgery and in exploratory measurements within neurology, ambulatory/bedside care or sepsis, addressing unmet discovery and clinical needs.


year authors and title journal last update
List of publications.
2019 Nikolaos-Kosmas Chlis, Angelos Karlas, Nikolina-Alexia Fasoula, Michael Kallmayer, Hans-Henning Eckstein, Fabian J Theis, Vasilis Ntziachristos, Carsten Marr
A Sparse Deep Learning Approach for Automatic Segmentation of Human Vasculature in Multispectral Optoacoustic Tomography
published pages: , ISSN: , DOI: 10.1101/833251
bioRxiv doi: 2020-02-28
2019 Maria Anastasopoulou, Dimitris Gorpas, Maximilian Koch, Evangelos Liapis, Sarah Glasl, Uwe Klemm, Angelos Karlas, Tobias Lasser, Vasilis Ntziachristos
Fluorescence imaging reversion using spatially variant deconvolution
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-54578-0
Scientific Reports 9/1 2020-02-28
2019 Miguel A. Pleitez, Asrar Ali Khan, Alice Soldà, Andriy Chmyrov, Josefine Reber, Francesca Gasparin, Markus R. Seeger, Benedikt Schätz, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos
Label-free metabolic imaging by mid-infrared optoacoustic microscopy in living cells
published pages: , ISSN: 1087-0156, DOI: 10.1038/s41587-019-0359-9
Nature Biotechnology 2020-02-04
2019 Avihai Ron, Xosé Luís Deán-Ben, Josephine Reber, Vasilis Ntziachristos, Daniel Razansky
Characterization of Brown Adipose Tissue in a Diabetic Mouse Model with Spiral Volumetric Optoacoustic Tomography
published pages: 620-625, ISSN: 1536-1632, DOI: 10.1007/s11307-018-1291-y
Molecular Imaging and Biology 21/4 2019-08-29
2018 Christoffer Clemmensen, Sigrid Jall, Maximilian Kleinert, Carmelo Quarta, Tim Gruber, Josefine Reber, Stephan Sachs, Katrin Fischer, Annette Feuchtinger, Angelos Karlas, Stephanie E. Simonds, Gerald Grandl, Daniela Loher, Eva Sanchez-Quant, Susanne Keipert, Martin Jastroch, Susanna M. Hofmann, Emmani B. M. Nascimento, Patrick Schrauwen, Vasilis Ntziachristos, Michael A. Cowley, Brian Finan, Timo D
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06769-y
Nature Communications 9/1 2019-08-29
2019 B. Hindelang, J. Aguirre, M. Schwarz, A. Berezhnoi, K. Eyerich, V. Ntziachristos, T. Biedermann, U. Darsow
Non‐invasive imaging in dermatology and the unique potential of raster‐scan optoacoustic mesoscopy
published pages: 1051-1061, ISSN: 0926-9959, DOI: 10.1111/jdv.15342
Journal of the European Academy of Dermatology and Venereology 33/6 2019-08-29
2019 Serafeim Moustakidis, Murad Omar, Juan Aguirre, Pouyan Mohajerani, Vasilis Ntziachristos
Fully automated identification of skin morphology in raster‐scan optoacoustic mesoscopy using artificial intelligence
published pages: , ISSN: 0094-2405, DOI: 10.1002/mp.13725
Medical Physics 2019-08-29
2019 Angelos Karlas, Nikolina-Alexia Fasoula, Korbinian Paul-Yuan, Josefine Reber, Michael Kallmayer, Dmitry Bozhko, Markus Seeger, Hans-Henning Eckstein, Moritz Wildgruber, Vasilis Ntziachristos
Cardiovascular optoacoustics: From mice to men – A review
published pages: 19-30, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2019.03.001
Photoacoustics 14 2019-08-29
2019 Vasilis Ntziachristos, Miguel A. Pleitez, Silvio Aime, Kevin M. Brindle
Emerging Technologies to Image Tissue Metabolism
published pages: 518-538, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.09.004
Cell Metabolism 29/3 2019-08-29
2019 Suhanyaa Nitkunanantharajah, Guillaume Zahnd, Malini Olivo, Nassir Navab, Pouyan Mohajerani, Vasilis Ntziachristos
Skin surface detection in 3D optoacoustic mesoscopy based on dynamic programming
published pages: 1-1, ISSN: 0278-0062, DOI: 10.1109/tmi.2019.2928393
IEEE Transactions on Medical Imaging 2019-08-29
2019 Juan Aguirre, Andrei Berezhnoi, Hailong He, Mathias Schwarz, Benedikt Hindelang, Murad Omar, Vasilis Ntziachristos
Motion Quantification and Automated Correction in Clinical RSOM
published pages: 1340-1346, ISSN: 0278-0062, DOI: 10.1109/tmi.2018.2883154
IEEE Transactions on Medical Imaging 38/6 2019-08-29
2018 Miguel A. Pleitez, Asrar Ali Khan, Josefine Reber, Andriy Chmyrov, Markus R. Seeger, Stephan Herzig, Marcel Scheideler, Vasilis Ntziachristos
Mid-infrared optoacoustic microscopy with label-free chemical contrast in living cells and tissues
published pages: , ISSN: , DOI: 10.1101/270082
bioRxiv February 22, 2018 2019-08-29
2019 Vipul Gujrati, Jaya Prakash, Jaber Malekzadeh-Najafabadi, Andre Stiel, Uwe Klemm, Gabriele Mettenleiter, Michaela Aichler, Axel Walch, Vasilis Ntziachristos
Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09034-y
Nature Communications 10/1 2019-08-29
2017 Angelos Karlas, Josefine Reber, Gael Diot, Dmitry Bozhko, Maria Anastasopoulou, Tareq Ibrahim, Markus Schwaiger, Fabien Hyafil, Vasilis Ntziachristos
Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept
published pages: 3395, ISSN: 2156-7085, DOI: 10.1364/boe.8.003395
Biomedical Optics Express 8/7 2019-06-13
2018 Andrei Berezhnoi, Mathias Schwarz, Andreas Buehler, Saak V. Ovsepian, Juan Aguirre, Vasilis Ntziachristos
Assessing hyperthermia-induced vasodilation in human skin in vivo using optoacoustic mesoscopy
published pages: e201700359, ISSN: 1864-063X, DOI: 10.1002/jbio.201700359
Journal of Biophotonics 2019-06-13
2018 J. Aguirre, B. Hindelang, Andrei Berezhnoi, U. Darsow, F. Lauffer, K. Eyerich, T. Biedermann, V. Ntziachristos
Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy
published pages: 31-37, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.02.002
Photoacoustics 10 2019-06-13
2017 Jaya Prakash, Subhamoy Mandal, Daniel Razansky, Vasilis Ntziachristos
Maximum entropy based non-negative optoacoustic tomographic image reconstruction
published pages: , ISSN: , DOI:
arXiv:1707.08391 2019-06-13

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