Baby DCs SIGNED
Age-dependent Regulation of Dendritic Cell Development and Function
Total Cost €
0EC-Contrib. €
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Project "Baby DCs" data sheet
The following table provides information about the project.
| Coordinator |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙500˙000 € |
| EC max contribution | 1˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-06-01 to 2022-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 1˙500˙000.00 |
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Project objective
Early life immune balance is essential for survival and establishment of healthy immunity in later life. We aim to define how age-dependent regulation of dendritic cell (DC) development contributes to this crucial immune balance. DCs are versatile controllers of immunity that in neonates are qualitatively distinct from adults. Why such age-dependent differences exist is unclear but newborn DCs are considered underdeveloped and functionally immature. Using ontogenetic tracing of conventional DC precursors, I have found a previously unappreciated developmental heterogeneity of DCs that is particularly prominent in young mice. Preliminary data indicate that distinct waves of DC poiesis contribute to the functional differences between neonatal and adult DCs. I hypothesize that the neonatal DC compartment is not immature but rather that DC poiesis is developmentally regulated to create essential age-dependent immune balance. Further, I have identified a unique situation in early life to address a fundamental biological question, namely to what extent cellular function is pre-programmed by developmental origin (nature) versus environmental factors (nurture). In this proposal, we will first use novel models to fate map the origin of the DC compartment with age. We will then define to what extent cellular origin determines age-dependent functions of DCs in immunity. Using innovative comparative gene expression profiling and integrative epigenomic analysis the cell intrinsic mechanisms regulating the age-dependent functions of DCs will be characterized. Because environmental factors in utero and after birth critically influence immune balance, we will finally define the impact of maternal infection and metabolic disease, as well as early microbial encounter on DC poiesis. Characterizing how developmentally regulated DC poiesis shapes the unique features of early life immunity will provide novel insights into immune development that are vital to advance vaccine strategies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Natallia Salei, Stephan Rambichler, Johanna Salvermoser, Nikos E. Papaioannou, Ronja Schuchert, Dalia Pakalniškytė, Na Li, Julian A. Marschner, Julia Lichtnekert, Christopher Stremmel, Filippo M. Cernilogar, Melanie Salvermoser, Barbara Walzog, Tobias Straub, Gunnar Schotta, Hans-Joachim Anders, Christian Schulz, Barbara U. Schraml The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties published pages: ASN.2019040419, ISSN: 1046-6673, DOI: 10.1681/asn.2019040419 |
Journal of the American Society of Nephrology | 2020-02-04 |
| 2019 |
Nikos E. Papaioannou, Maria Pasztoi, Barbara U. Schraml Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03123 |
Frontiers in Immunology 9 | 2020-02-04 |
| 2018 |
Johanna Salvermoser, Janneke van Blijswijk, Nikos E. Papaioannou, Stephan Rambichler, Maria Pasztoi, Dalia Pakalniškytė, Neil C. Rogers, Selina J. Keppler, Tobias Straub, Caetano Reis e Sousa, Barbara U. Schraml Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00699 |
Frontiers in Immunology 9 | 2019-02-27 |
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