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Baby DCs SIGNED

Age-dependent Regulation of Dendritic Cell Development and Function

Total Cost €

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EC-Contrib. €

0

Partnership

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 Baby DCs project word cloud

Explore the words cloud of the Baby DCs project. It provides you a very rough idea of what is the project "Baby DCs" about.

data    birth    contributes    controllers    influence    microbial    fate    newborn    disease    dendritic    mice    critically    preliminary    developmental    expression    versus    functional    shapes    functionally    infection    healthy    regulated    gene    exist    function    qualitatively    life    dependent    ontogenetic    maternal    strategies    profiling    programmed    developmentally    survival    age    innovative    indicate    insights    later    epigenomic    nurture    adults    utero    neonatal    metabolic    integrative    immature    determines    compartment    young    create    unappreciated    biological    immunity    versatile    conventional    characterizing    hypothesize    regulation    question    unclear    waves    prominent    dcs    mechanisms    cellular    origin    neonates    heterogeneity    vital    intrinsic    fundamental    cell    establishment    regulating    balance    encounter    functions    tracing    differences    situation    immune    nature    early    underdeveloped    poiesis    adult    precursors    map    vaccine    first    previously    found    models    dc    environmental   

Project "Baby DCs" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 1˙500˙000.00

Map

 Project objective

Early life immune balance is essential for survival and establishment of healthy immunity in later life. We aim to define how age-dependent regulation of dendritic cell (DC) development contributes to this crucial immune balance. DCs are versatile controllers of immunity that in neonates are qualitatively distinct from adults. Why such age-dependent differences exist is unclear but newborn DCs are considered underdeveloped and functionally immature. Using ontogenetic tracing of conventional DC precursors, I have found a previously unappreciated developmental heterogeneity of DCs that is particularly prominent in young mice. Preliminary data indicate that distinct waves of DC poiesis contribute to the functional differences between neonatal and adult DCs. I hypothesize that the neonatal DC compartment is not immature but rather that DC poiesis is developmentally regulated to create essential age-dependent immune balance. Further, I have identified a unique situation in early life to address a fundamental biological question, namely to what extent cellular function is pre-programmed by developmental origin (nature) versus environmental factors (nurture). In this proposal, we will first use novel models to fate map the origin of the DC compartment with age. We will then define to what extent cellular origin determines age-dependent functions of DCs in immunity. Using innovative comparative gene expression profiling and integrative epigenomic analysis the cell intrinsic mechanisms regulating the age-dependent functions of DCs will be characterized. Because environmental factors in utero and after birth critically influence immune balance, we will finally define the impact of maternal infection and metabolic disease, as well as early microbial encounter on DC poiesis. Characterizing how developmentally regulated DC poiesis shapes the unique features of early life immunity will provide novel insights into immune development that are vital to advance vaccine strategies.

 Publications

year authors and title journal last update
List of publications.
2020 Natallia Salei, Stephan Rambichler, Johanna Salvermoser, Nikos E. Papaioannou, Ronja Schuchert, Dalia Pakalniškytė, Na Li, Julian A. Marschner, Julia Lichtnekert, Christopher Stremmel, Filippo M. Cernilogar, Melanie Salvermoser, Barbara Walzog, Tobias Straub, Gunnar Schotta, Hans-Joachim Anders, Christian Schulz, Barbara U. Schraml
The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties
published pages: ASN.2019040419, ISSN: 1046-6673, DOI: 10.1681/asn.2019040419
Journal of the American Society of Nephrology 2020-02-04
2019 Nikos E. Papaioannou, Maria Pasztoi, Barbara U. Schraml
Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.03123
Frontiers in Immunology 9 2020-02-04
2018 Johanna Salvermoser, Janneke van Blijswijk, Nikos E. Papaioannou, Stephan Rambichler, Maria Pasztoi, Dalia Pakalniškytė, Neil C. Rogers, Selina J. Keppler, Tobias Straub, Caetano Reis e Sousa, Barbara U. Schraml
Clec9a-Mediated Ablation of Conventional Dendritic Cells Suggests a Lymphoid Path to Generating Dendritic Cells In Vivo
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00699
Frontiers in Immunology 9 2019-02-27

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