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GasPlaNt SIGNED

Gas sensing in plants:Oxygen- and nitric oxide-regulated chromatin modification via a targeted protein degradation mechanism

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EC-Contrib. €

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Project "GasPlaNt" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙495˙340 €
 EC max contribution 1˙495˙340 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 1˙495˙340.00

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 Project objective

Oxygen (O2) and nitric oxide (NO) are gases that function as key developmental and stress-associated signals in plants. Investigating the molecular basis of their perception has the potential to identify new targets for crop improvement. In previous ground breaking work I showed that the direct transcriptional response to O2/NO is mediated by controlled degradation of specialised ‘gas-sensing’ transcription factors. We have now linked this degradation mechanism to a new functional class of ‘sensor’, a chromatin modifying protein that regulates the epigenetic silencing of genes. Here we will investigate the hypothesis that this protein acts as a previously undiscovered link between O2/NO and chromatin dynamics, and that plants have evolved a unique system for transducing gaseous signals into rapid transcriptional responses, and longer term epigenetic changes, through targeting different types of protein to the same degradation pathway. Using multidisciplinary genetic, biochemical and omics approaches we will investigate the molecular basis of this novel gas perception system, which appears to be a plant-specific innovation. We will identify its global gene targets (the ‘gas-responsive epigenome’), and uncover its growth and stress-associated functions in Arabidopsis and barley. We will also investigate how manipulating this pathway using genome editing and synthetic biology techniques alters plant performance, focusing on traits of agronomic significance. This ambitious and timely research will take our knowledge of O2/NO-signaling and the control of chromatin dynamics beyond the current state of the art by offering insight into a completely novel signaling mechanism operating at the interface of gas-perception, protein degradation, and epigenetics. GasPlaNt will therefore provide a step-change in our understanding of how plants synchronise their gene expression in response to signals to optimise growth and development within a dynamic environment.

 Publications

year authors and title journal last update
List of publications.
2020 Anne‐Marie Labandera, Hannah M. Tedds, Mark Bailey, Colleen Sprigg, Ross D. Etherington, Olunwatunmise Akintewe, Geetika Kalleechurn, Michael J. Holdsworth, Daniel J. Gibbs
The PRT6 N‐degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development
published pages: , ISSN: 0028-646X, DOI: 10.1111/nph.16477
New Phytologist 2020-04-14
2018 Daniel J. Gibbs, Hannah M. Tedds, Anne-Marie Labandera, Mark Bailey, Mark D. White, Sjon Hartman, Colleen Sprigg, Sophie L. Mogg, Rory Osborne, Charlene Dambire, Tinne Boeckx, Zachary Paling, Laurentius A. C. J. Voesenek, Emily Flashman, Michael J. Holdsworth
Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07875-7
Nature Communications 9/1 2020-04-14
2019 Chih-Cheng Lin, Ya-Ting Chao, Wan-Chieh Chen, Hsiu-Yin Ho, Mei-Yi Chou, Ya-Ru Li, Yu-Lin Wu, Hung-An Yang, Hsiang Hsieh, Choun-Sea Lin, Fu-Hui Wu, Shu-Jen Chou, Hao-Chung Jen, Yung-Hsiang Huang, Deli Irene, Wen-Jin Wu, Jian-Li Wu, Daniel J. Gibbs, Meng-Chiao Ho, Ming-Che Shih
Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence
published pages: 3300-3309, ISSN: 0027-8424, DOI: 10.1073/pnas.1818507116
Proceedings of the National Academy of Sciences 116/8 2020-04-14

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