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GlycoImaging SIGNED

Imaging and detection of tumor-associated glycan structures on tumor cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GlycoImaging project word cloud

Explore the words cloud of the GlycoImaging project. It provides you a very rough idea of what is the project "GlycoImaging" about.

polymers antibodies biomarkers balanced buffer meat biomedical shown diagnostics humans digital neu5ac follow particle training neu5gc glycan holographic microscopy faster business magnetic phosphate metastatic cancers techniques acid fluorescence basis care aggressive sa packages exploited human synthesis competent efficiency 3d spectrum cheaper blood technological plastic skills sialic red tissue solvents assays imaging cancer cells sources incorporated malignant entrepreneurial glyco samips performed laboratories consisting detection one transformation water dietary columns biomarker esrs expression quality accurate cell company separation biochemistry stage drug discovery emphasis glycoconjugates mips urine health glycans education interdisciplinary methanol imprinted groups scientific ing forms molecularly

Project "GlycoImaging" data sheet

The following table provides information about the project.

Coordinator	MALMO UNIVERSITET Organization address address: NORDENSKIOLDSGATAN 1 city: MALMOE postcode: 205 06 website: www.mah.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://glycoimaging.mau.se
Total cost	2˙138˙720 €
EC max contribution	2˙138˙720 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MALMO UNIVERSITET MALMO UNIVERSITET Organization address address: NORDENSKIOLDSGATAN 1 city: MALMOE postcode: 205 06 website: www.mah.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (MALMOE)	coordinator	263˙659.00
2	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	580˙163.00
3	BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG Organization address address: Unter den Eichen 87 city: BERLIN postcode: 12205 website: www.bam.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	498˙432.00
4	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	269˙145.00
5	PHASE HOLOGRAPHIC IMAGING PHI AB PHASE HOLOGRAPHIC IMAGING PHI AB Organization address address: SCHEELEVAGEN 22 city: LUND postcode: 223 63 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	participant	263˙659.00
6	UMEA UNIVERSITET UMEA UNIVERSITET Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 website: www.umu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	participant	263˙659.00

Map

Project objective

The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns. The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research.

8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

Deliverables

List of deliverables.
Produce a minimum of 2 press releases	Websites, patent fillings, videos etc.	2020-02-17 15:41:04
Project website launched	Websites, patent fillings, videos etc.	2020-02-17 15:41:04
Produce a project poster and a presentation	Websites, patent fillings, videos etc.	2020-02-17 15:41:04

Take a look to the deliverables list in detail: detailed list of GlycoImaging deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Borje Sellergren, Zahra El-Schich, Anette Gjorloff Wingren Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid published pages: , ISSN: 2454-2857, DOI: 10.20517/2394-4722.2018.112	Journal of Cancer Metastasis and Treatment 2019	2020-02-17
2019	Ville TÃ¤htinen, Alejandra Verhassel, Johanna Tuomela, Pasi Markus Virta Î³â€(S)â€Guanidinylmethyl Modified Triplexâ€Forming Peptide Nucleic Acids Increase Hoogsteenâ€Face Affinity for a MicroRNA and Enhance Cellular Uptake published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900393	ChemBioChem	2020-02-17
2019	Yoshiki Narimatsu, Hiren J. Joshi, Rebecca Nason, Julie Van Coillie, Richard Karlsson, Lingbo Sun, Zilu Ye, Yen-Hsi Chen, Katrine T. Schjoldager, Catharina Steentoft, Sanae Furukawa, Barbara A. Bensing, Paul M. Sullam, Andrew J. Thompson, James C. Paulson, Christian BÃ¼ll, Gosse J. Adema, Ulla Mandel, Lars Hansen, Eric Paul Bennett, Ajit Varki, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells published pages: 394-407.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.05.017	Molecular Cell 75/2	2020-02-17
2018	Yen-Hsi Chen, Yoshiki Narimatsu, Thomas M. Clausen, Catarina Gomes, Richard Karlsson, Catharina Steentoft, Charlotte B. Spliid, Tobias Gustavsson, Ali Salanti, Andrea Persson, Anders MalmstrÃ¶m, Daniel WillÃ©n, Ulf Ellervik, Eric P. Bennett, Yang Mao, Henrik Clausen, Zhang Yang The GAGOme: a cell-based library of displayed glycosaminoglycans published pages: 881-888, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0086-z	Nature Methods 15/11	2020-02-17
2019	Louise SternbÃ¦k, Martha Wamaitha Kimani, Kornelia Gawlitza Birgit Janicke, Kersti Alm, and Anette GjÃ¶rloff Wingren Digital holographic cytometry - Macrophage uptake of nanoprobes published pages: 21-23, ISSN: , DOI:	Imaging&Microscopy 1	2020-02-17

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The information about "GLYCOIMAGING" are provided by the European Opendata Portal: CORDIS opendata.