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GlycoImaging SIGNED

Imaging and detection of tumor-associated glycan structures on tumor cells

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoImaging project word cloud

Explore the words cloud of the GlycoImaging project. It provides you a very rough idea of what is the project "GlycoImaging" about.

human    cells    cancer    skills    samips    neu5ac    imaging    assays    glycan    forms    biomarker    detection    neu5gc    metastatic    aggressive    sa    training   

Project "GlycoImaging" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
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surname: n.a.
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email: n.a.
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 Coordinator Country Sweden [SE]
 Total cost 2˙138˙720 €
 EC max contribution 2˙138˙720 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme /MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 263˙659.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 580˙163.00
3    BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG DE (BERLIN) participant 498˙432.00
4    TURUN YLIOPISTO FI (Turku) participant 269˙145.00
5    PHASE HOLOGRAPHIC IMAGING PHI AB SE (LUND) participant 263˙659.00
6    UMEA UNIVERSITET SE (UMEA) participant 263˙659.00

Mappa

 Project objective

The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns. The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research.

8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "GLYCOIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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