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GlycoImaging SIGNED

Imaging and detection of tumor-associated glycan structures on tumor cells

Total Cost €

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EC-Contrib. €

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Partnership

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 GlycoImaging project word cloud

Explore the words cloud of the GlycoImaging project. It provides you a very rough idea of what is the project "GlycoImaging" about.

competent    tissue    urine    laboratories    faster    spectrum    human    basis    drug    quality    separation    diagnostics    performed    synthesis    biomarkers    ing    discovery    entrepreneurial    company    sialic    follow    methanol    esrs    meat    acid    glyco    imprinted    groups    malignant    metastatic    one    assays    glycans    phosphate    shown    mips    fluorescence    balanced    cell    efficiency    incorporated    forms    business    red    sources    packages    digital    expression    microscopy    water    buffer    antibodies    neu5gc    emphasis    plastic    aggressive    magnetic    scientific    care    glycoconjugates    polymers    biomedical    cancers    imaging    cells    neu5ac    stage    glycan    cancer    techniques    biochemistry    education    3d    consisting    biomarker    particle    skills    solvents    humans    interdisciplinary    technological    detection    transformation    training    columns    accurate    molecularly    samips    holographic    blood    health    exploited    cheaper    dietary    sa   

Project "GlycoImaging" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Sweden [SE]
 Project website http://glycoimaging.mau.se
 Total cost 2˙138˙720 €
 EC max contribution 2˙138˙720 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 263˙659.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 580˙163.00
3    BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG DE (BERLIN) participant 498˙432.00
4    TURUN YLIOPISTO FI (Turku) participant 269˙145.00
5    PHASE HOLOGRAPHIC IMAGING PHI AB SE (LUND) participant 263˙659.00
6    UMEA UNIVERSITET SE (UMEA) participant 263˙659.00

Map

 Project objective

The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns. The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research.

8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.

 Deliverables

List of deliverables.
Produce a minimum of 2 press releases Websites, patent fillings, videos etc. 2020-02-17 15:41:04
Project website launched Websites, patent fillings, videos etc. 2020-02-17 15:41:04
Produce a project poster and a presentation Websites, patent fillings, videos etc. 2020-02-17 15:41:04

Take a look to the deliverables list in detail:  detailed list of GlycoImaging deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Yuecheng Zhang, Kushtrim Llapashtica, Sudhirkumar Shinde, Borje Sellergren, Zahra El-Schich, Anette Gjorloff Wingren
Determination of cytokine regulated glycan expression by using molecularly imprinted polymers targeting sialic acid
published pages: , ISSN: 2454-2857, DOI: 10.20517/2394-4722.2018.112
Journal of Cancer Metastasis and Treatment 2019 2020-02-17
2019 Ville Tähtinen, Alejandra Verhassel, Johanna Tuomela, Pasi Markus Virta
γ‐(S)‐Guanidinylmethyl Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201900393
ChemBioChem 2020-02-17
2019 Yoshiki Narimatsu, Hiren J. Joshi, Rebecca Nason, Julie Van Coillie, Richard Karlsson, Lingbo Sun, Zilu Ye, Yen-Hsi Chen, Katrine T. Schjoldager, Catharina Steentoft, Sanae Furukawa, Barbara A. Bensing, Paul M. Sullam, Andrew J. Thompson, James C. Paulson, Christian Büll, Gosse J. Adema, Ulla Mandel, Lars Hansen, Eric Paul Bennett, Ajit Varki, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
published pages: 394-407.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.05.017
Molecular Cell 75/2 2020-02-17
2018 Yen-Hsi Chen, Yoshiki Narimatsu, Thomas M. Clausen, Catarina Gomes, Richard Karlsson, Catharina Steentoft, Charlotte B. Spliid, Tobias Gustavsson, Ali Salanti, Andrea Persson, Anders Malmström, Daniel Willén, Ulf Ellervik, Eric P. Bennett, Yang Mao, Henrik Clausen, Zhang Yang
The GAGOme: a cell-based library of displayed glycosaminoglycans
published pages: 881-888, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0086-z
Nature Methods 15/11 2020-02-17
2019 Louise Sternbæk, Martha Wamaitha Kimani, Kornelia Gawlitza Birgit Janicke, Kersti Alm, and Anette Gjörloff Wingren
Digital holographic cytometry - Macrophage uptake of nanoprobes
published pages: 21-23, ISSN: , DOI:
Imaging&Microscopy 1 2020-02-17

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The information about "GLYCOIMAGING" are provided by the European Opendata Portal: CORDIS opendata.

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