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BiofoulRepel SIGNED

Biofoulant-repelling surfaces for catheters and other biomedical devices

Total Cost €

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EC-Contrib. €

0

Partnership

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 BiofoulRepel project word cloud

Explore the words cloud of the BiofoulRepel project. It provides you a very rough idea of what is the project "BiofoulRepel" about.

demonstrated    seek    frequent       lipids    form    interfaces    planktonic    fracture    extremely    showed    complexes    contacts    competitive    industrial    discoveries    neutralizing    tissue    hospital    layers    stents    render    liposomes    bilayers    2x106    proteins    lipid    threatening    suppressing    commercialization    expose    intended    50    biomedical    massively    huge    grafts    anti    bacteria    packages    contacting    alone    validate    fixation    contact    morbidity    surfaces    fouling    treatments    antibiotic    human    boundary    undesirable    exceed    heart    prostheses    carry    market    resistant    times    polymer    made    apart    position    curing    object    suitable    appropriate    health    dose    repellent    valves    1000    ipr    burden    hydrated    proof    phosphatidylcholine       lubricating    overcome    implanted    adsorption    actual    feasibility    explore    modify    treatment    surface    joint    hydrogel    pc    infections    biofilm    suffering    lenses    catheters    hydrationlube       vascular    biofoulants    impose    erc    medical    hai    infected   

Project "BiofoulRepel" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

The object of this proof of concept project is to modify the surfaces of biomedical devices intended for contact with human tissue, such as catheters, stents or contact lenses, to render them repellent to biofoulants, based on discoveries made in our current ERC project HydrationLube. This will render such surfaces, and the devices, far more resistant to health-threatening infections. Our ERC project demonstrated that boundary layers based on phosphatidylcholine (PC) lipids (in the form of liposomes, bilayers or polymer-lipid complexes) can expose extremely hydrated interfaces, which are not only strongly lubricating but, as we recently showed, are also capable – particularly at hydrogel surfaces - of massively suppressing the adsorption of common biofoulants including proteins and bacteria. We now propose to use this finding to overcome, through suitable surface treatment, the undesirable effects of such fouling and biofilm formation on tissue-contacting devices, which impose a huge health and cost burden. Thus, neutralizing bacteria in biofilm may require a 1000-times higher dose of antibiotic compared to planktonic bacteria. Moreover, such infections are frequent: some 4% of all implanted vascular grafts and medical heart valves become infected, as do 2% of implanted joint prostheses and 5% of the 2x106 fracture fixation devices that are used in the U.S. alone each year. The cost of curing such infections may exceed $50,000 per case, apart from the burden of human suffering and morbidity, and they account for over 50% of all Hospital Associated Infections (HAI). The current project, working through 5 work-packages, will validate the feasibility of such anti-fouling treatments on actual devices, will carry out competitive analysis and market research, explore the commercialization process and the IPR position, and seek contacts with appropriate industrial partners to further develop the commercialization of our technology.

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The information about "BIOFOULREPEL" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2020-10-21 8:04:59) correctly updated