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BiofoulRepel SIGNED

Biofoulant-repelling surfaces for catheters and other biomedical devices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BiofoulRepel project word cloud

Explore the words cloud of the BiofoulRepel project. It provides you a very rough idea of what is the project "BiofoulRepel" about.

discoveries    carry    suffering    competitive    bacteria    explore    position    stents    phosphatidylcholine    contacts    anti    massively    prostheses    seek    liposomes    feasibility    implanted    ipr    surfaces    huge    threatening    frequent    object    extremely    layers    neutralizing    50    fouling    boundary    lenses    hai    polymer    proteins    treatments    expose    lipid    infections    tissue    market    interfaces    vascular    modify       biofoulants    overcome    repellent    burden    demonstrated    render    antibiotic    resistant    contact    alone    fracture    heart    2x106    curing          pc    1000    health    appropriate    lubricating    human    erc    industrial    validate    treatment    proof    made    infected    medical    apart    contacting    form    grafts    hospital    suppressing    joint    biomedical    lipids    morbidity    hydrationlube    exceed    undesirable    hydrogel    adsorption    complexes    actual    bilayers    valves    dose    showed    catheters    times    planktonic    packages    hydrated    impose    commercialization    suitable    intended    biofilm    surface    fixation   

Project "BiofoulRepel" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

The object of this proof of concept project is to modify the surfaces of biomedical devices intended for contact with human tissue, such as catheters, stents or contact lenses, to render them repellent to biofoulants, based on discoveries made in our current ERC project HydrationLube. This will render such surfaces, and the devices, far more resistant to health-threatening infections. Our ERC project demonstrated that boundary layers based on phosphatidylcholine (PC) lipids (in the form of liposomes, bilayers or polymer-lipid complexes) can expose extremely hydrated interfaces, which are not only strongly lubricating but, as we recently showed, are also capable – particularly at hydrogel surfaces - of massively suppressing the adsorption of common biofoulants including proteins and bacteria. We now propose to use this finding to overcome, through suitable surface treatment, the undesirable effects of such fouling and biofilm formation on tissue-contacting devices, which impose a huge health and cost burden. Thus, neutralizing bacteria in biofilm may require a 1000-times higher dose of antibiotic compared to planktonic bacteria. Moreover, such infections are frequent: some 4% of all implanted vascular grafts and medical heart valves become infected, as do 2% of implanted joint prostheses and 5% of the 2x106 fracture fixation devices that are used in the U.S. alone each year. The cost of curing such infections may exceed $50,000 per case, apart from the burden of human suffering and morbidity, and they account for over 50% of all Hospital Associated Infections (HAI). The current project, working through 5 work-packages, will validate the feasibility of such anti-fouling treatments on actual devices, will carry out competitive analysis and market research, explore the commercialization process and the IPR position, and seek contacts with appropriate industrial partners to further develop the commercialization of our technology.

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The information about "BIOFOULREPEL" are provided by the European Opendata Portal: CORDIS opendata.

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