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BiofoulRepel SIGNED

Biofoulant-repelling surfaces for catheters and other biomedical devices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BiofoulRepel project word cloud

Explore the words cloud of the BiofoulRepel project. It provides you a very rough idea of what is the project "BiofoulRepel" about.

huge    proof    lubricating    pc    competitive    grafts    infected    market    surfaces    undesirable    extremely    planktonic    explore    demonstrated    massively    actual    treatments    dose    treatment    frequent    biomedical    implanted    interfaces    render    hospital    intended    human    contact       made    morbidity    50    health    burden    contacts    boundary    position    apart    heart    complexes    prostheses    seek    appropriate    surface    feasibility    adsorption    lenses    neutralizing    bacteria    commercialization    suitable    liposomes    curing       form    impose    valves    layers    medical    exceed    fracture    phosphatidylcholine    stents    showed    contacting    times    ipr    hai    expose    joint    tissue    discoveries    industrial    fouling    alone    carry    vascular    fixation    threatening    1000    lipids    catheters    object    suffering    2x106    validate    infections    overcome    suppressing    resistant    antibiotic    hydrogel    biofoulants    anti    biofilm    packages    polymer    proteins    modify    bilayers    hydrated    lipid    repellent       hydrationlube    erc   

Project "BiofoulRepel" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 150˙000.00

Map

 Project objective

The object of this proof of concept project is to modify the surfaces of biomedical devices intended for contact with human tissue, such as catheters, stents or contact lenses, to render them repellent to biofoulants, based on discoveries made in our current ERC project HydrationLube. This will render such surfaces, and the devices, far more resistant to health-threatening infections. Our ERC project demonstrated that boundary layers based on phosphatidylcholine (PC) lipids (in the form of liposomes, bilayers or polymer-lipid complexes) can expose extremely hydrated interfaces, which are not only strongly lubricating but, as we recently showed, are also capable – particularly at hydrogel surfaces - of massively suppressing the adsorption of common biofoulants including proteins and bacteria. We now propose to use this finding to overcome, through suitable surface treatment, the undesirable effects of such fouling and biofilm formation on tissue-contacting devices, which impose a huge health and cost burden. Thus, neutralizing bacteria in biofilm may require a 1000-times higher dose of antibiotic compared to planktonic bacteria. Moreover, such infections are frequent: some 4% of all implanted vascular grafts and medical heart valves become infected, as do 2% of implanted joint prostheses and 5% of the 2x106 fracture fixation devices that are used in the U.S. alone each year. The cost of curing such infections may exceed $50,000 per case, apart from the burden of human suffering and morbidity, and they account for over 50% of all Hospital Associated Infections (HAI). The current project, working through 5 work-packages, will validate the feasibility of such anti-fouling treatments on actual devices, will carry out competitive analysis and market research, explore the commercialization process and the IPR position, and seek contacts with appropriate industrial partners to further develop the commercialization of our technology.

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The information about "BIOFOULREPEL" are provided by the European Opendata Portal: CORDIS opendata.

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