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MILEAGE SIGNED

Microelements in Life Expectancy and Aging

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MILEAGE project word cloud

Explore the words cloud of the MILEAGE project. It provides you a very rough idea of what is the project "MILEAGE" about.

genes    transporter    pancreatic    hepatocytes    consequent    influence    limits    exchange    metals    normal    expression    longevity    older    socioeconomic    diminished    flux    channels    dysregulation    plays    population    increased    ageing    skills    advice    dietary    interdisciplinary    gut    composition    cellular    transporters    absorption    metal    demographics    homeostasis    personal    health    thousands    transfer    healthcare    excretion    informing    functions    lifelong    maintaining    absorptive    age    clear    mechanisms    cu    countries    chaperones    functioning    leads    molecular    senescence    perturbed    contributions    understand    lifestyle    body    intersectoral    acinar    trafficking    mucosal    microelements    transport    determined    model    regulation    quality    excretory    desirable    expertise    copper    zinc    microbiota    life    links    reducing    individuals    satisfaction    combines    mathematical    intervention    regulating    predictive    status    zn    nutrition    kinetics    supplementation    proteins    disease    cells    output    expressed   

Project "MILEAGE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE PICARDIE JULES VERNE 

Organization address
address: CHEMIN DU THIL
city: AMIENS
postcode: 80025
website: www.u-picardie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.rise-mileage.eu
 Total cost 864˙000 €
 EC max contribution 864˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE PICARDIE JULES VERNE FR (AMIENS) coordinator 247˙500.00
2    THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN UK (ABERDEEN) participant 292˙500.00
3    LIMITED LIABILITY COMPANY RESEARCH AND PRODUCTION ENTERPRISE I.F. LAB UA (KYIV) participant 211˙500.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 112˙500.00
5    Instituto Nacional de Higiene, Epidemiología y Microbiología CU (Havana) partner 0.00
6    THE UNIVERSITY OF THE WEST INDIES U WI* JM (KINGSTON) partner 0.00
7    UNIVERSIDAD DE CHILE CL (SANTIAGO) partner 0.00

Map

 Project objective

Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are: 1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu. 2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters. 3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.

 Deliverables

List of deliverables.
International Workshop Proceedings Documents, reports 2019-07-23 17:13:48

Take a look to the deliverables list in detail:  detailed list of MILEAGE deliverables.

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The information about "MILEAGE" are provided by the European Opendata Portal: CORDIS opendata.

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