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MILEAGE SIGNED

Microelements in Life Expectancy and Aging

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MILEAGE project word cloud

Explore the words cloud of the MILEAGE project. It provides you a very rough idea of what is the project "MILEAGE" about.

genes transporter pancreatic hepatocytes consequent influence limits exchange metals normal expression longevity older socioeconomic diminished flux channels dysregulation plays population increased ageing skills advice dietary interdisciplinary gut composition cellular transporters absorption metal demographics homeostasis personal health thousands transfer healthcare excretion informing functions lifelong maintaining absorptive age clear mechanisms cu countries chaperones functioning leads molecular senescence perturbed contributions understand lifestyle body intersectoral acinar trafficking mucosal microelements transport determined model regulation quality excretory desirable expertise copper zinc microbiota life links reducing individuals satisfaction combines mathematical intervention regulating predictive status zn nutrition kinetics supplementation proteins disease cells output expressed

Project "MILEAGE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE PICARDIE JULES VERNE Organization address address: CHEMIN DU THIL city: AMIENS postcode: 80025 website: www.u-picardie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.rise-mileage.eu
Total cost	864˙000 €
EC max contribution	864˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE PICARDIE JULES VERNE UNIVERSITE DE PICARDIE JULES VERNE Organization address address: CHEMIN DU THIL city: AMIENS postcode: 80025 website: www.u-picardie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (AMIENS)	coordinator	247˙500.00
2	THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN Organization address address: KING'S COLLEGE REGENT WALK city: ABERDEEN postcode: AB24 3FX website: http://www.abdn.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABERDEEN)	participant	292˙500.00
3	LIMITED LIABILITY COMPANY RESEARCH AND PRODUCTION ENTERPRISE I.F. LAB LIMITED LIABILITY COMPANY RESEARCH AND PRODUCTION ENTERPRISE I.F. LAB Organization address address: 9 DRUZHBY NARODIV BLVD. city: KYIV postcode: 1042 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UA (KYIV)	participant	211˙500.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	112˙500.00
5	Instituto Nacional de Higiene, Epidemiología y Microbiología Instituto Nacional de Higiene, Epidemiología y Microbiología Organization address address: Infanta No. 1158 city: Havana postcode: 10 300 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CU (Havana)	partner	0.00
6	THE UNIVERSITY OF THE WEST INDIES U WI* THE UNIVERSITY OF THE WEST INDIES U WI* Organization address address: MONA city: KINGSTON postcode: 7 website: www.sta.uwi.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JM (KINGSTON)	partner	0.00
7	UNIVERSIDAD DE CHILE UNIVERSIDAD DE CHILE Organization address address: Av. Libertador Bernardo O'Higgins 1058 city: SANTIAGO postcode: 10 website: www.uchile.cl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SANTIAGO)	partner	0.00

Map

Project objective

Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity. The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are: 1. To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu. 2. To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters. 3. To determine how senescence affects the transporter proteins, channels and chaperones involved in regulating Zn and Cu trafficking through the key absorptive and excretory cells affecting body metal homeostasis.

Deliverables

List of deliverables.
International Workshop Proceedings	Documents, reports	2019-07-23 17:13:48

Take a look to the deliverables list in detail: detailed list of MILEAGE deliverables.

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The information about "MILEAGE" are provided by the European Opendata Portal: CORDIS opendata.

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