Explore the words cloud of the TRANSPOS-X project. It provides you a very rough idea of what is the project "TRANSPOS-X" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙500˙000 €|
|EC max contribution||2˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||2˙500˙000.00|
Transposable elements (TEs) account for more than two thirds of the human genome. They can inactivate genes, provide novel coding functions, sprinkle chromosomes with recombination-prone repetitive sequences, and modulate cellular gene expression through a wide variety of transcriptional and posttranscriptional influences. As a consequence, TEs are considered as essential motors of evolution yet they are occasionally associated with disease, causing about one hundred Mendelian disorders and possibly contributing to several human cancers. As expected for such genomic threats, TEs are subjected to tight epigenetic control imposed from the very first days of embryogenesis, in part owing to their recognition by sequence-specific RNA- and protein-based repressors. It is generally considered that the evolutionary selection of these TE controllers reflects a simple host-pathogen arms race, and that their action results in the early and permanent silencing of their targets. We have recently uncovered new evolutionary evidence and obtained genomic and functional data that invalidate this dual assumption, and suggest instead that transposable elements and their epigenetic controllers establish species-specific transcriptional networks that play critical roles in human development and physiology. The general objective of the present proposal is to explore the breadth of this phenomenon, to decipher its mechanisms, to unveil its functional implications, and to probe how this knowledge could be exploited for basic research, biotechnology and clinical medicine.
|year||authors and title||journal||last update|
Annamaria Kauzlaric, Suk Min Jang, Mehdi Morchikh, Marco Cassano, Evarist Planet, Monsef Benkirane, Didier Trono
KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity
published pages: 20190334, ISSN: 0962-8436, DOI: 10.1098/rstb.2019.0334
|Philosophical Transactions of the Royal Society B: Biological Sciences 375/1795||2020-03-05|
Alberto De Iaco, Sonia Verp, Sandra Offner, Delphine Grun, Didier Trono
DUX is a non-essential synchronizer of zygotic genome activation
published pages: dev177725, ISSN: 0950-1991, DOI: 10.1242/dev.177725
Andrea Coluccio, Gabriela Ecco, Julien Duc, Sandra Offner, Priscilla Turelli, Didier Trono
Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naÃ¯ve embryonic stem cells
published pages: , ISSN: 1756-8935, DOI: 10.1186/s13072-018-0177-1
|Epigenetics & Chromatin 11/1||2019-06-13|
Gabriela Ecco, Michael Imbeault, Didier Trono
KRAB zinc finger proteins
published pages: 2719-2729, ISSN: 0950-1991, DOI: 10.1242/dev.132605
Suk Min Jang, Annamaria Kauzlaric, Jean-Pierre Quivy, Julien Pontis, Benjamin Rauwel, Andrea Coluccio, Sandra Offner, Julien Duc, Priscilla Turelli, GeneviÃ¨ve Almouzni, Didier Trono
KAP1 facilitates reinstatement of heterochromatin after DNA replication
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky580
|Nucleic Acids Research||2019-06-13|
Marco Cassano, Sandra Offner, Evarist Planet, Alessandra Piersigilli, Suk Min Jang, Hugues Henry, Markus B. Geuking, Catherine Mooser, Kathy D. McCoy, Andrew J. Macpherson, Didier Trono
Polyphenic trait promotes liver cancer in a model of epigenetic instability in mice
published pages: 235-251, ISSN: 0270-9139, DOI: 10.1002/hep.29182
A KRABsody for Embryo-Placental Development
published pages: 578-580, ISSN: 1534-5807, DOI: 10.1016/j.devcel.2017.06.005
|Developmental Cell 41/6||2019-06-13|
Annamaria Kauzlaric, Gabriela Ecco, Marco Cassano, Julien Duc, Michael Imbeault, Didier Trono
The mouse genome displays highly dynamic populations of KRAB-zinc finger protein genes and related genetic units
published pages: e0173746, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0173746
|PLOS ONE 12/3||2019-06-13|
Alberto De Iaco, Evarist Planet, Andrea Coluccio, Sonia Verp, Julien Duc, Didier Trono
DUX-family transcription factors regulate zygotic genome activation in placental mammals
published pages: 941-945, ISSN: 1061-4036, DOI: 10.1038/ng.3858
|Nature Genetics 49/6||2019-06-13|
Julien Pontis, Evarist Planet, Sandra Offner, Priscilla Turelli, Julien Duc, Alexandre Coudray, Thorold W. Theunissen, Rudolf Jaenisch, Didier Trono
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
published pages: 724-735.e5, ISSN: 1934-5909, DOI: 10.1016/j.stem.2019.03.012
|Cell Stem Cell 24/5||2019-08-29|
Nozomi Takahashi, Andrea Coluccio, Christian W. Thorball, Evarist Planet, Hui Shi, Sandra Offner, Priscilla Turelli, Michael Imbeault, Anne C. Ferguson-Smith, Didier Trono
ZNF445 is a primary regulator of genomic imprinting
published pages: 49-54, ISSN: 0890-9369, DOI: 10.1101/gad.320069.118
|Genes & Development 33/1-2||2019-08-29|
Alberto De Iaco, Alexandre Coudray, Julien Duc, Didier Trono
DPPA2 and DPPA4 are necessary to establish a 2Câ€like state in mouse embryonic stem cells
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847382
|EMBO reports 20/5||2019-08-29|
Pierreâ€Yves Helleboid, Moritz Heusel, Julien Duc, CÃ©cile Piot, Christian W Thorball, Andrea Coluccio, Julien Pontis, MichaÃ«l Imbeault, Priscilla Turelli, Ruedi Aebersold, Didier Trono
The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2018101220
|The EMBO Journal||2019-08-29|
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