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MultipleMS SIGNED

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MultipleMS project word cloud

Explore the words cloud of the MultipleMS project. It provides you a very rough idea of what is the project "MultipleMS" about.

clinical healthcare background validate lifestyle progression young validation biological treatment broad efficient immune combination heterogeneities disability pathophysiology stratification inflammatory guided patients 21 cohorts populations clinically mediated interactions world patient big broadly basic gain maps interventions chronic heterogeneity manifestations global strategic pathogenic causes adults benefit optimal conceptual biomarkers computational goes diseases genetic data therapies disease setting stratified create course personalized stage sclerosis medicine entails pharmaceutical expertise readily multiplems policies gene full biomarker synergies innovation decision traumatic types translating thereby spectrum industry covers publically reflected six 37 multiple omics significantly diversity

Project "MultipleMS" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	https://www.multiplems.eu/
Total cost	15˙041˙259 €
EC max contribution	14˙721˙453 € (98%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2016-RTD
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	3˙040˙166.00
2	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	1˙916˙171.00
3	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	1˙623˙011.00
4	ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES Organization address address: 2211 ELLIOTT AVENUE SUITE 200 city: SEATTLE postcode: 98121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SEATTLE)	participant	1˙497˙155.00
5	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Organization address address: FRANKLIN STREET 1111, 12 FLOOR city: OAKLAND CA postcode: 94607 website: http://www.universityofcalifornia.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (OAKLAND CA)	participant	1˙278˙427.00
6	YH YOUHEALTH AB YH YOUHEALTH AB Organization address address: FOGDEVRETEN 2 KAROLINSKA SCIENCE city: STOCKHOLM postcode: 171 77 website: www.youhealth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	1˙263˙333.00
7	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	547˙721.00
8	UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO Organization address address: DUOMO 6 city: VERCELLI postcode: 13100 website: www.unipmn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERCELLI)	participant	547˙255.00
9	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	546˙321.00
10	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	366˙308.00
11	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	339˙103.00
12	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	318˙583.00
13	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	301˙403.00
14	POLICLINICO SAN DONATO SPA POLICLINICO SAN DONATO SPA Organization address address: VIA RODOLFO MORANDI 30 city: SAN DONATO MI postcode: 20097 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SAN DONATO MI)	participant	268˙691.00
15	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	262˙748.00
16	BIOCOMPUTING PLATFORMS LTD OY BIOCOMPUTING PLATFORMS LTD OY Organization address address: INNOPOLI 3 VAISALANTIE 6 city: ESPOO postcode: 2130 website: www.bcplatforms.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	219˙937.00
17	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	214˙870.00
18	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	100˙742.00
19	MABTECH AB MABTECH AB Organization address address: Augustendalsv 19 city: STOCKHOLM postcode: 13128 website: www.mabtech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	59˙000.00
20	SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT Organization address address: Pierre Brossolette 1 city: Chilly Mazarin postcode: 91380 website: www.sanofi-aventis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chilly Mazarin)	participant	7˙125.00
21	MEDIMMUNE LIMITED MEDIMMUNE LIMITED Organization address address: MILSTEIN BUILDING GRANTA PARK city: CAMBRIDGE postcode: CB21 6GH website: http://www.cambridgeantibody.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	3˙375.00
22	NEURIX SA NEURIX SA Organization address address: AVENUE DE LA ROSERAIE 64 city: GENEVE postcode: 1205 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	0.00

Map

Project objective

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations. MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of €37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions.

To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response. MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.

Deliverables

List of deliverables.
Data availability and knowledge discovery tool to monitor for the availability of the different data types	Other	2020-02-17 16:16:45
Project website	Websites, patent fillings, videos etc.	2020-02-17 16:16:45

Take a look to the deliverables list in detail: detailed list of MultipleMS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases published pages: , ISSN: 1742-2094, DOI: 10.1186/s12974-019-1601-6	Journal of Neuroinflammation 16/1	2020-03-05
2017	Simone Ecker, Stephan Beck Epigenetic variation taking center stage in immunological research published pages: 375-378, ISSN: 1750-1911, DOI: 10.2217/epi-2017-0006	Epigenomics 9/4	2020-02-17
2018	Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena LindÃ©n, Bartosz GÃ³rnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, BjÃ¶rn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh Rawal, Ulf Schminke, Carsten O. Schmidt, Tim Kacprowski, Andre Franke, Matthias Laudes, Alexander T. Dilthey, Elisabeth G. Celius, Helle B. SÃ¸ndergaard, Jesper TegnÃ©r, Hanne F. Harbo, Annette B. Oturai, Sigurgeir Olafsson, Hannes P. Eggertsson, Bjarni V. Halldorsson, Haukur Hjaltason, Elias Olafsson, Ingileif Jonsdottir, Kari Stefansson, Tomas Olsson, Fredrik Piehl, Tomas J. EkstrÃ¶m, Ingrid Kockum, Andrew P. Feinberg, Maja Jagodic *DNA methylation as a mediator of HLA-DRB115:01 and a protective variant in multiple sclerosis** published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04732-5	Nature Communications 9/1	2020-02-17
2018	Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes published pages: 1288-1300, ISSN: 1352-4585, DOI: 10.1177/1352458517721356	Multiple Sclerosis Journal 24/10	2020-02-17
2018	Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity published pages: 1700148, ISSN: 0265-9247, DOI: 10.1002/bies.201700148	BioEssays 40/2	2020-02-17
2017	Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, MÂ Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos GarcÃa GirÃ³n, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, William McLaren, Benjamin Moore, Jonathan Mudge, Daniel N Murphy, Victoria Newman, Michael Nuhn, Denye Ogeh, Chuang Kee Ong, Anne Parker, Mateus Patricio, Harpreet Singh Riat, Helen Schuilenburg, Dan Sheppard, Helen Sparrow, Kieron Taylor, Anja Thormann, Alessandro Vullo, Brandon Walts, Amonida Zadissa, Adam Frankish, Sarah E Hunt, Myrto Kostadima, Nicholas Langridge, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Dan M Staines, Stephen J Trevanion, Bronwen L Aken, Fiona Cunningham, Andrew Yates, Paul Flicek Ensembl 2018 published pages: D754-D761, ISSN: 0305-1048, DOI: 10.1093/nar/gkx1098	Nucleic Acids Research 46/D1	2020-02-17
2017	Francesco Marabita, Malin Almgren, Louise K. SjÃ¶holm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. EkstrÃ¶m, Maja Jagodic Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14788-w	Scientific Reports 7/1	2020-02-17
2018	Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-018-0575-9	Genome Medicine 10/1	2020-02-17
2018	Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis published pages: 205521731876719, ISSN: 2055-2173, DOI: 10.1177/2055217318767192	Multiple Sclerosis Journal - Experimental, Translational and Clinical 4/2	2020-02-17
2018	Adrian Liston, An Goris The origins of diversity in human immunity published pages: 209-210, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0047-9	Nature Immunology 19/3	2020-02-17
2017	Sigurgeir Olafsson, Pernilla Stridh, Steffan DaniÃ«l Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Thorarinn Gislason, Trausti Valdimarsson, Evgenia Mikaelsdottir, Snaevar Sigurdsson, Stefan Jonsson, Thorunn Rafnar, Dag Aarsland, Srdjan Djurovic, Tormod Fladby, Gun Peggy Knudsen, Elisabeth G. Celius, Kjell-Morten Myhr, Gerdur Grondal, Kristjan Steinsson, Helgi Valdimarsson, Sigurdur Bjornsson, Unnur S. Bjornsdottir, Einar S Bjornsson, Bjorn Nilsson, Ole A. Andreassen, Lars Alfredsson, Jan Hillert, Ingrid Skelton Kockum, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hreinn Stefansson, Haukur Hjaltason, Hanne F. Harbo, Tomas Olsson, Ingileif Jonsdottir, Kari Stefansson Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations published pages: , ISSN: 2056-7944, DOI: 10.1038/s41525-017-0027-2	npj Genomic Medicine 2/1	2020-02-17
2018	Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod published pages: 1046-1054, ISSN: 1352-4585, DOI: 10.1177/1352458517715132	Multiple Sclerosis Journal 24/8	2020-02-17
2018	Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, BÃ©nÃ©dicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells published pages: 786-796, ISSN: 0006-8950, DOI: 10.1093/brain/awx372	Brain 141/3	2020-02-17
2018	Tojo James, Magdalena LindÃ©n, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper TegnÃ©r, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients published pages: 912-928, ISSN: 0964-6906, DOI: 10.1093/hmg/ddy001	Human Molecular Genetics 27/5	2020-02-17

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The information about "MULTIPLEMS" are provided by the European Opendata Portal: CORDIS opendata.