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MultipleMS SIGNED

Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 MultipleMS project word cloud

Explore the words cloud of the MultipleMS project. It provides you a very rough idea of what is the project "MultipleMS" about.

combination    thereby    manifestations    interactions    37    validate    types    create    immune    diversity    efficient    validation    21    pathophysiology    disability    guided    expertise    clinically    goes    basic    treatment    significantly    stage    heterogeneity    publically    heterogeneities    stratified    background    industry    benefit    translating    entails    readily    six    lifestyle    computational    full    big    chronic    biomarkers    genetic    maps    broadly    interventions    reflected    conceptual    covers    traumatic    world    pathogenic    adults    causes    therapies    clinical    progression    populations    inflammatory    gain    course    medicine    diseases    strategic    policies    patient    gene    broad    innovation    patients    sclerosis    decision    personalized    optimal    biomarker    setting    pharmaceutical    stratification    global    healthcare    multiple    mediated    biological    cohorts    synergies    omics    multiplems    disease    data    spectrum    young   

Project "MultipleMS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.multiplems.eu/
 Total cost 15˙041˙259 €
 EC max contribution 14˙721˙453 € (98%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 3˙040˙166.00
2    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) participant 1˙916˙171.00
3    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 1˙623˙011.00
4    ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES US (SEATTLE) participant 1˙497˙155.00
5    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) participant 1˙278˙427.00
6    YH YOUHEALTH AB SE (STOCKHOLM) participant 1˙263˙333.00
7    UNIVERSITETET I OSLO NO (OSLO) participant 547˙721.00
8    UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO IT (VERCELLI) participant 547˙255.00
9    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 546˙321.00
10    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 366˙308.00
11    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 339˙103.00
12    REGION HOVEDSTADEN DK (HILLEROD) participant 318˙583.00
13    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) participant 301˙403.00
14    POLICLINICO SAN DONATO SPA IT (SAN DONATO MI) participant 268˙691.00
15    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 262˙748.00
16    BIOCOMPUTING PLATFORMS LTD OY FI (ESPOO) participant 219˙937.00
17    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 214˙870.00
18    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 100˙742.00
19    MABTECH AB SE (STOCKHOLM) participant 59˙000.00
20    SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT FR (Chilly Mazarin) participant 7˙125.00
21    MEDIMMUNE LIMITED UK (CAMBRIDGE) participant 3˙375.00
22    NEURIX SA CH (GENEVE) participant 0.00

Map

 Project objective

The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations. MultipleMS will therefore develop, validate, and exploit methods for patient stratification in Multiple Sclerosis, a chronic inflammatory disease and a leading causes of non-traumatic disability in young adults, with an estimated cost of €37 000 per patient per year over a duration of 30 years. Here we benefit from several large clinical cohorts with multiple data types, including genetic and lifestyle information. This in combination with publically available multi-omics maps enables us to identify biomarkers of the clinical course and the response to existing therapies in a real-world setting, and to gain in-depth knowledge of distinct pathogenic pathways setting the stage for development of new interventions.

To create strategic global synergies, MultipleMS includes 21 partners and covers not only the necessary clinical, biological, and computational expertise, but also includes six industry partners ensuring dissemination and exploitation of the methods and clinical decision support system. Moreover, the pharmaceutical industry partners provide expertise to ensure optimal selection and validation of clinically relevant biomarkers and new targets. Our conceptual personalized approach can readily be adapted to other immune-mediated diseases with a complex gene-lifestyle background and broad clinical spectrum with heterogeneity in treatment response. MultipleMS therefore goes significantly beyond current state-of-the-art thereby broadly affecting European policies, healthcare systems, innovation in translating big data and basic research into evidence-based personalized clinical applications.

 Deliverables

List of deliverables.
Data availability and knowledge discovery tool to monitor for the availability of the different data types Other 2020-02-17 16:16:45
Project website Websites, patent fillings, videos etc. 2020-02-17 16:16:45

Take a look to the deliverables list in detail:  detailed list of MultipleMS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases
published pages: , ISSN: 1742-2094, DOI: 10.1186/s12974-019-1601-6
Journal of Neuroinflammation 16/1 2020-03-05
2017 Simone Ecker, Stephan Beck
Epigenetic variation taking center stage in immunological research
published pages: 375-378, ISSN: 1750-1911, DOI: 10.2217/epi-2017-0006
Epigenomics 9/4 2020-02-17
2018 Lara Kular, Yun Liu, Sabrina Ruhrmann, Galina Zheleznyakova, Francesco Marabita, David Gomez-Cabrero, Tojo James, Ewoud Ewing, Magdalena Lindén, Bartosz Górnikiewicz, Shahin Aeinehband, Pernilla Stridh, Jenny Link, Till F. M. Andlauer, Christiane Gasperi, Heinz Wiendl, Frauke Zipp, Ralf Gold, Björn Tackenberg, Frank Weber, Bernhard Hemmer, Konstantin Strauch, Stefanie Heilmann-Heimbach, Rajesh Rawal, Ulf Schminke, Carsten O. Schmidt, Tim Kacprowski, Andre Franke, Matthias Laudes, Alexander T. Dilthey, Elisabeth G. Celius, Helle B. Søndergaard, Jesper Tegnér, Hanne F. Harbo, Annette B. Oturai, Sigurgeir Olafsson, Hannes P. Eggertsson, Bjarni V. Halldorsson, Haukur Hjaltason, Elias Olafsson, Ingileif Jonsdottir, Kari Stefansson, Tomas Olsson, Fredrik Piehl, Tomas J. Ekström, Ingrid Kockum, Andrew P. Feinberg, Maja Jagodic
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04732-5
Nature Communications 9/1 2020-02-17
2018 Sabrina Ruhrmann, Ewoud Ewing, Eliane Piket, Lara Kular, Julio Cesar Cetrulo Lorenzi, Sunjay Jude Fernandes, Hiromasa Morikawa, Shahin Aeinehband, Sergi Sayols-Baixeras, Stella Aslibekyan, Devin M Absher, Donna K Arnett, Jesper Tegner, David Gomez-Cabrero, Fredrik Piehl, Maja Jagodic
Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes
published pages: 1288-1300, ISSN: 1352-4585, DOI: 10.1177/1352458517721356
Multiple Sclerosis Journal 24/10 2020-02-17
2018 Simone Ecker, Vera Pancaldi, Alfonso Valencia, Stephan Beck, Dirk S. Paul
Epigenetic and Transcriptional Variability Shape Phenotypic Plasticity
published pages: 1700148, ISSN: 0265-9247, DOI: 10.1002/bies.201700148
BioEssays 40/2 2020-02-17
2017 Daniel R Zerbino, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Daniel Barrell, Jyothish Bhai, Konstantinos Billis, Carla Cummins, Astrid Gall, Carlos García Girón, Laurent Gil, Leo Gordon, Leanne Haggerty, Erin Haskell, Thibaut Hourlier, Osagie G Izuogu, Sophie H Janacek, Thomas Juettemann, Jimmy Kiang To, Matthew R Laird, Ilias Lavidas, Zhicheng Liu, Jane E Loveland, Thomas Maurel, William McLaren, Benjamin Moore, Jonathan Mudge, Daniel N Murphy, Victoria Newman, Michael Nuhn, Denye Ogeh, Chuang Kee Ong, Anne Parker, Mateus Patricio, Harpreet Singh Riat, Helen Schuilenburg, Dan Sheppard, Helen Sparrow, Kieron Taylor, Anja Thormann, Alessandro Vullo, Brandon Walts, Amonida Zadissa, Adam Frankish, Sarah E Hunt, Myrto Kostadima, Nicholas Langridge, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Dan M Staines, Stephen J Trevanion, Bronwen L Aken, Fiona Cunningham, Andrew Yates, Paul Flicek
Ensembl 2018
published pages: D754-D761, ISSN: 0305-1048, DOI: 10.1093/nar/gkx1098
Nucleic Acids Research 46/D1 2020-02-17
2017 Francesco Marabita, Malin Almgren, Louise K. Sjöholm, Lara Kular, Yun Liu, Tojo James, Nimrod B. Kiss, Andrew P. Feinberg, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Tomas J. Ekström, Maja Jagodic
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14788-w
Scientific Reports 7/1 2020-02-17
2018 Amy P. Webster, Darren Plant, Simone Ecker, Flore Zufferey, Jordana T. Bell, Andrew Feber, Dirk S. Paul, Stephan Beck, Anne Barton, Frances M. K. Williams, Jane Worthington
Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins
published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-018-0575-9
Genome Medicine 10/1 2020-02-17
2018 Patricia Lechner, Dorothea Buck, Lisa Sick, Bernhard Hemmer, Gabriele Multhoff
Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis
published pages: 205521731876719, ISSN: 2055-2173, DOI: 10.1177/2055217318767192
Multiple Sclerosis Journal - Experimental, Translational and Clinical 4/2 2020-02-17
2018 Adrian Liston, An Goris
The origins of diversity in human immunity
published pages: 209-210, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0047-9
Nature Immunology 19/3 2020-02-17
2017 Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Thorarinn Gislason, Trausti Valdimarsson, Evgenia Mikaelsdottir, Snaevar Sigurdsson, Stefan Jonsson, Thorunn Rafnar, Dag Aarsland, Srdjan Djurovic, Tormod Fladby, Gun Peggy Knudsen, Elisabeth G. Celius, Kjell-Morten Myhr, Gerdur Grondal, Kristjan Steinsson, Helgi Valdimarsson, Sigurdur Bjornsson, Unnur S. Bjornsdottir, Einar S Bjornsson, Bjorn Nilsson, Ole A. Andreassen, Lars Alfredsson, Jan Hillert, Ingrid Skelton Kockum, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hreinn Stefansson, Haukur Hjaltason, Hanne F. Harbo, Tomas Olsson, Ingileif Jonsdottir, Kari Stefansson
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
published pages: , ISSN: 2056-7944, DOI: 10.1038/s41525-017-0027-2
npj Genomic Medicine 2/1 2020-02-17
2018 Fredrik Piehl, Ingrid Kockum, Mohsen Khademi, Kaj Blennow, Jan Lycke, Henrik Zetterberg, Tomas Olsson
Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod
published pages: 1046-1054, ISSN: 1352-4585, DOI: 10.1177/1352458517715132
Multiple Sclerosis Journal 24/8 2020-02-17
2018 Ide Smets, Barnaby Fiddes, Josselyn E Garcia-Perez, Di He, Klara Mallants, Wenjia Liao, James Dooley, George Wang, Stephanie Humblet-Baron, Bénédicte Dubois, Alastair Compston, Joanne Jones, Alasdair Coles, Adrian Liston, Maria Ban, An Goris, Stephen Sawcer
Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells
published pages: 786-796, ISSN: 0006-8950, DOI: 10.1093/brain/awx372
Brain 141/3 2020-02-17
2018 Tojo James, Magdalena Lindén, Hiromasa Morikawa, Sunjay Jude Fernandes, Sabrina Ruhrmann, Mikael Huss, Maya Brandi, Fredrik Piehl, Maja Jagodic, Jesper Tegnér, Mohsen Khademi, Tomas Olsson, David Gomez-Cabrero, Ingrid Kockum
Impact of genetic risk loci for multiple sclerosis on expression of proximal genes in patients
published pages: 912-928, ISSN: 0964-6906, DOI: 10.1093/hmg/ddy001
Human Molecular Genetics 27/5 2020-02-17

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