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Catalyst Cascade Reactions in ‘One-Flow’ within a Compartmentalized, Green-Solvent ‘Digital Synthesis Machinery’ – End-to-End Green Process Design for Pharmaceuticals

Total Cost €


EC-Contrib. €






 One-Flow project word cloud

Explore the words cloud of the One-Flow project. It provides you a very rough idea of what is the project "One-Flow" about.

guided    reactor    auspices    500    oversight    computer    tech    synthetic    ultimate    opportunity    organising    chemocatalysts    nature    million    40    flow    sustainability    eur    list    central    organic    consecutive    34    monitoring    spaces    point    machine    scientist    compartmentalized    solvent    reaction    synthesis    saving    senior    platform    medicine    signaling    billion    continuous    drugs    automated    cascade    200    sme    fluidically    38    market    passage    relegation    full    internet    manageable    10    invented    winning    female    players    green    compartmentalization    massive    amenable    factory    junior    orthogonality    biomimetic    medication    digital    harmonization    cascades    disease    spaciants    transfer    chemical    vi    personalized    translates    interim    300    things    alter    mechanical    vertical    systemic    drug    catalytic    chemists    uplift    operations    virtue    base    self    evaluation    share    diseases    windows    hierarchy    commercial    horizontal    machinery    inorganic    smart    57    data    metabolic    multistep    bio    2020    reactions    spaciant    keep    landscape    intelligence   

Project "One-Flow" data sheet

The following table provides information about the project.


Organization address
address: GROENE LOPER 3
postcode: 5612 AE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙896˙827 €
 EC max contribution 3˙896˙827 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) participant 482˙690.00
3    TECHNISCHE UNIVERSITAET GRAZ AT (GRAZ) participant 404˙940.00
4    UNIVERSITAET BIELEFELD DE (BIELEFELD) participant 401˙750.00
8    UNIVERSITY OF HULL UK (HULL) participant 344˙672.00


 Project objective

'ONE-FLOW translates ‘vertical hierarchy’ of chemical multistep synthesis with its complex machinery into self-organising ‘horizontal hierarchy’ of a compartmentalized flow reactor system – a biomimetic digital flow cascade machinery with just one reactor passage. To keep horizontal hierarchy manageable, orthogonality among the consecutive reactions needs to be increased. The winning point of nature is to have invented catalytic cascades. ONE-FLOW will uplift that by enabling the best bio- and chemocatalysts working hand in hand. 4 synthetic flow cascades ('metabolic pathways’) and 1 flow cascade driven by automated intelligence ('signaling pathway') will produce 4 Top-list 2020 drugs. ‘The Compartmentalized Smart Factory’ will develop organic, inorganic, and mechanical compartmentalization. ‘The Green-Solvent Spaciant Factory’ will fluidically allow the use of interim reaction spaces (spaciants). ‘The Systemic Operations Factory’ will aim at full orthogonality using data-base guided ultimate process harmonization. ‘The Digital Machine-to-Machine Factory’ will alter the landscape of chemical synthesis by virtue of the 'Internet of Chemical Things'. Automated machine-to-machine data transfer enables relegation of process monitoring to central computer systems under the oversight of chemists. ‘The Fully Continuous Integrated Factory’ will develop a commercial platform technology under the auspices of sustainability-driven process-design evaluation, making amenable the new kind of processing to all chemists. ONE-FLOW has massive impact potential: i) 38 billion Euro production cost saving; ii) 300 million EUR cost saving per drug; iii) address diseases with 500 billion Euro medication costs; iv) increase market share of emerging high-tech SME players by 10% in 10 years; v) open new windows of opportunity (personalized medicine) with 200-500 million Euro per disease; and vi) achieve 40% female share on a senior scientist level (ONE-FLOW: 34% senior, 57% junior).'


List of deliverables.
Cascade 3 - b) synthesis of Sacubitril Documents, reports 2020-04-16 13:41:05
Exploiting iterative reactivity of boronic acids via flow generated reactive intermediates Documents, reports 2020-04-16 13:42:09
Polymersome-based improvement of cascade 1: a) harmonization of catalyst & solvent Documents, reports 2020-04-16 13:42:45
Cascade 1 - synthesis of cannabinoid derivatives Documents, reports 2020-04-16 13:42:38
Periodic report action check meeting 2 Documents, reports 2020-04-16 13:42:31
Development of a critical process parameter map Documents, reports 2020-04-16 13:42:24
A new generic microcontroller remote command and control device for chemical reactions in flow Documents, reports 2020-04-16 13:42:03
Application of the systemic operation factory in cascade 4 Documents, reports 2020-04-16 13:41:56
Data acquisition Documents, reports 2020-04-16 13:41:43
Shifting the epimerization equilibrium of cascade 2 Documents, reports 2020-04-16 13:41:36
Spaciant-based solvent dispersion and unification for cascade 4 Documents, reports 2020-04-16 13:41:30
Application of the microcontroller in cascade 1 Documents, reports 2020-04-16 13:42:17
Criteria definition and orthogonality decision execution Documents, reports 2020-04-16 13:41:50
Catalyst slurries in multi-phase micro-flows Documents, reports 2020-04-16 13:41:23
Cascade 4 - Synthesis of Capecitabine Documents, reports 2020-04-16 13:41:17
Enable a co-catalyst flow operation for cascade 3 Documents, reports 2020-04-16 13:41:11
Cascade 2 - synthesis of ursodeoxycholic acid Documents, reports 2020-04-16 13:42:54
Cascade 3 – a) synthesis of Valsartan Documents, reports 2020-01-20 16:19:30
Technical action check meeting 1 Documents, reports 2020-01-20 16:19:30
Data Management Plan Open Research Data Pilot 2020-01-20 16:19:30
Project webpage and logo Websites, patent fillings, videos etc. 2020-01-20 16:19:29

Take a look to the deliverables list in detail:  detailed list of One-Flow deliverables.


year authors and title journal last update
List of publications.
2019 Katharina Hiebler, Carina Dertnig, Sebastian Soritz, Manuel C. Maier, Theresa R. Hörmann, Bianca Grabner, Heidrun Gruber-Woelfler
Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow
published pages: , ISSN: 2062-249X, DOI: 10.1007/s41981-019-00058-5
Journal of Flow Chemistry 2020-03-06
2019 Ana Maria Bago Rodriguez, Bernard P. Binks
Capsules from Pickering emulsion templates
published pages: 107-129, ISSN: 1359-0294, DOI: 10.1016/j.cocis.2019.09.006
Current Opinion in Colloid & Interface Science 44 2020-03-06
2018 Fabio Tonin, Isabel W C E Arends
Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review
published pages: 470-483, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.33
Beilstein Journal of Organic Chemistry 14 2020-02-20
2019 Victor R. L. J. Bloemendal, Daan Sondag, Hidde Elferink, Thomas J. Boltje, Jan. C. M. van Hest, Floris P. J. T. Rutjes
A Revised Modular Approach to (-)- trans -Δ 8 -THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions
published pages: 2289-2296, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900059
European Journal of Organic Chemistry 2019/12 2020-02-20
2019 Xin Yang, Yaolei Wang, Ruixue Bai, Hulin Ma, Weihao Wang, Hejia Sun, Yuman Dong, Fengmei Qu, Qiming Tang, Ting Guo, Bernard P. Binks, Tao Meng
Pickering emulsion-enhanced interfacial biocatalysis: tailored alginate microparticles act as particulate emulsifier and enzyme carrier
published pages: 2229-2233, ISSN: 1463-9262, DOI: 10.1039/c8gc03573c
Green Chemistry 21/9 2020-02-20
2019 Olivia Maria Morales-Gonzalez, Marc Escribà-Gelonch, Volker Hessel
Life cycle assessment of vitamin D3 synthesis: from batch to photo-high p,T
published pages: 2111-2127, ISSN: 0948-3349, DOI: 10.1007/s11367-019-01634-6
The International Journal of Life Cycle Assessment 24/12 2020-02-20
2020 Chenyue Zhang, Zhen Song, Can Jin, Job Nijhuis, Teng Zhou, Timothy Noël, Harald Gröger, Kai Sundmacher, Jan van Hest, Volker Hessel
Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach
published pages: 123399, ISSN: 1385-8947, DOI: 10.1016/j.cej.2019.123399
Chemical Engineering Journal 385 2020-02-20
2019 O.M. Morales-Gonzalez, C. Zhang, S. Li, V. Hessel
Solvent impact assessment for the “One-Flow Functional Solvent Factory”
published pages: 100024, ISSN: 2590-1400, DOI: 10.1016/j.cesx.2019.100024
Chemical Engineering Science: X 3 2020-02-20
2019 Katharina Hiebler, Sebastian Soritz, Kristian Gavric, Sam Birrer, Manuel C. Maier, Bianca Grabner, Heidrun Gruber-Woelfler
Multistep synthesis of a valsartan precursor in continuous flow
published pages: , ISSN: 2062-249X, DOI: 10.1007/s41981-019-00044-x
Journal of Flow Chemistry 2020-02-20
2019 Victor R. L. J. Bloemendal, Sam J. Moons, Jurriaan J. A. Heming, Mohamed Chayoua, Olaf Niesink, Jan C. M. van Hest, Thomas J. Boltje, Floris P. J. T. Rutjes
Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐ Acetylneuraminate Lyase in a Continuous Flow Reactor
published pages: , ISSN: 1615-4150, DOI: 10.1002/adsc.201900146
Advanced Synthesis & Catalysis 2020-02-20
2019 Steven V. Ley, Yiding Chen, Daniel E. Fitzpatrick, Oliver May
A New World for Chemical Synthesis?
published pages: 792-802, ISSN: 0009-4293, DOI: 10.2533/chimia.2019.792
CHIMIA International Journal for Chemistry 73/10 2020-02-04
2020 Eiichi Watanabe, Yiding Chen, Oliver May, Steven V. Ley
A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters
published pages: 186-191, ISSN: 0947-6539, DOI: 10.1002/chem.201905048
Chemistry – A European Journal 26/1 2020-02-04
2020 Daniel E. Fitzpatrick, Matthew O\'Brien, Steven V. Ley
A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
published pages: , ISSN: 2058-9883, DOI: 10.1039/c9re00407f
Reaction Chemistry & Engineering 2020-02-04
2019 Yiding Chen, Oliver May, David C. Blakemore, Steven V. Ley
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
published pages: 6140-6144, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.9b02307
Organic Letters 21/15 2020-02-04
2017 Andreas Greb, Jian-Siang Poh, Stephanie Greed, Claudio Battilocchio, Patrick Pasau, David C. Blakemore, Steven V. Ley
A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions
published pages: 16602-16605, ISSN: 1433-7851, DOI: 10.1002/anie.201710445
Angewandte Chemie International Edition 56/52 2020-01-20
2018 Dougal J. Ritson, Claudio Battilocchio, Steven V. Ley, John D. Sutherland
Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04147-2
Nature Communications 9/1 2020-01-20
2018 Katharina Hiebler, Georg J Lichtenegger, Manuel C Maier, Eun Sung Park, Renie Gonzales-Groom, Bernard P Binks, Heidrun Gruber-Woelfler
Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry
published pages: 648-658, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.52
Beilstein Journal of Organic Chemistry 14 2020-01-20
2018 M Teresa De Martino, Loai K E A Abdelmohsen, Floris P J T Rutjes, Jan C M van Hest
Nanoreactors for green catalysis
published pages: 716-733, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.61
Beilstein Journal of Organic Chemistry 14 2020-01-20
2019 Lukas Schober, Shahilan Ratnam, Yasunobu Yamashita, Niklas Adebar, Matthias Pieper, Albrecht Berkessel, Volker Hessel, Harald Gröger
An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode
published pages: 1178-1184, ISSN: 0039-7881, DOI: 10.1055/s-0037-1610404
Synthesis 51/05 2020-01-20
2018 Yiding Chen, David C. Blakemore, Patrick Pasau, Steven V. Ley
Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor
published pages: 6569-6572, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b02907
Organic Letters 20/20 2020-01-20
2018 Daniel E. Fitzpatrick, Robbie J. Mutton, Steven V. Ley
In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system
published pages: 799-806, ISSN: 2058-9883, DOI: 10.1039/c8re00107c
Reaction Chemistry & Engineering 3/5 2020-01-20
2018 Yiding Chen, Marco Leonardi, Paul Dingwall, Ricardo Labes, Patrick Pasau, David C. Blakemore, Steven V. Ley
Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow
published pages: 15558-15568, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b02721
The Journal of Organic Chemistry 83/24 2020-01-20
2018 Paul Dingwall, Andreas Greb, Lorène N. S. Crespin, Ricardo Labes, Biagia Musio, Jian-Siang Poh, Patrick Pasau, David C. Blakemore, Steven V. Ley
C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow
published pages: 11685-11688, ISSN: 1359-7345, DOI: 10.1039/c8cc06202a
Chemical Communications 54/83 2020-01-20
2018 Daniel E. Fitzpatrick, Timothé Maujean, Amanda C. Evans, Steven V. Ley
Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server
published pages: 15128-15132, ISSN: 1433-7851, DOI: 10.1002/anie.201809080
Angewandte Chemie International Edition 57/46 2020-01-20

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