Explore the words cloud of the CHEMBIOHISTONE project. It provides you a very rough idea of what is the project "CHEMBIOHISTONE" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-11-01 to 0000-00-00|
Take a look of project's partnership.
|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||183˙454.00|
Studying biomolecules in living cells is an important step towards understanding the cause and development of diseases. However, the existing tools dedicated to the study of biomolecules often lack generality and pose disturbance to the biological systems. Although bioorthogonal chemistry plays an important role in biomolecule studies, there are only a handful of bioorthogonal reactions that can modify these molecules in vivo. In this project, we will develop a novel biocompatible reaction that can be widely used for modifying biomolecules both in vitro and in vivo. We will then employ the reaction to reveal the biological significance of post-translational modifications (PTMs) of histones proteins by using two strategies. First, the histone mimics that are not accessible by the existing methods will be synthesized. These histone mimics can serve as important models for us to understand the interactions between histones and their regulating enzymes. Second, real-time imaging of histone PTMs in living cells will be made possible by using a chemical biology approach. This approach can minimize the disturbance to the three-dimensional structure of the nucleosome, thereby providing a true image of dynamic histone PTMs during cellular processes. In short, this multidisciplinary project lies on the interface of organic chemistry, biochemistry, and cell biology, with an aim to enable the in-depth studies of the unknown aspect of epigenetics.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHEMBIOHISTONE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CHEMBIOHISTONE" are provided by the European Opendata Portal: CORDIS opendata.
Photocatalysis in Drug Discovery - Asymmetric Preparation of Bioactive Chiral Lactones and CyclohexanolsRead More
Phase-separated block copolymer nanoparticles for spatial organization of enzymes: A new strategy to control enzyme cascade reactionsRead More
A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problemsRead More