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VascArbor SIGNED

Vascular Tree Formation in Multi-Structural Tissue Engineering

Total Cost €

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EC-Contrib. €

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Partnership

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Project "VascArbor" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT TWENTE 

Organization address
address: DRIENERLOLAAN 5
city: ENSCHEDE
postcode: 7522 NB
website: www.utwente.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT TWENTE NL (ENSCHEDE) coordinator 2˙000˙000.00

Map

 Project objective

Engineered tissues offer a great promise to the field of medicine as an alternative for donor tissues, for which the supply is not meeting the demands. However, the clinical application of engineered tissues is hampered. The integration of engineered tissues after implantation is limited due to the lack of a vascular network. Currently, strategies to include vascular networks rely on the spontaneous organization of vascular cells, or on the patterning of these cells. However, this results in either vascular networks that are not organized, or networks that lose their initial organization fast. This project will use a unique and novel approach to control vascular development and will therefore result in a vascular network with a controllable long-term organization. By allowing for anastomosis, and increasing nutrient delivery, this project will tackle an essential problem and will greatly enhance the clinical applicability of engineered tissues.

Within VascArbor, fluid flows through engineered tissues will be designed and controlled to guide vascular organization. Apart from that, growth factors will be patterned in space and time to further direct the formation of a vascular network with a controlled organization. In parallel, computational models will be developed that can predict vascular organization and development based on processing parameters. This will be a breakthrough in vascularized tissue engineering by enabling a direct link between a desired vascular organization, and the tissue construct geometry and processing conditions that are needed to acquire this organization.

To maximize the impact of VascArbor on the field of tissue engineering and medicine, the principles that will guide vascular organization are compatible with multiple current and future tissue fabrication technologies. Within VascArbor, tissue building blocks and bio-printing will be used to engineer vascularized cardiac muscle tissue based on the principles developed in this project.

 Publications

year authors and title journal last update
List of publications.
2019 Trikalitis, V.; Stein, F.; Perea Paizal, J.; Slahei Nik, N.; Rouwkema, J.
Adaptation of 3D printing bioinks to mimic the mechanical properties of embryonic tissue for the purpose of vascularization
published pages: , ISSN: , DOI:
TERMIS European Chapter Meeting 2019: Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation 2019-10-08
2018 João Ribas, Joanna Pawlikowska, Jeroen Rouwkema
Microphysiological systems: analysis of the current status, challenges and commercial future
published pages: 1-1, ISSN: 2616-275X, DOI: 10.21037/mps.2018.10.01
Microphysiological Systems 1 2019-10-08
2018 Trikalitis, V.; Stein, F.; Perea Paizal, J.; Salehi Nik, N.; Rouwkema, J.
Angiogenic sprouting of spheroids jammed within a granular medium
published pages: , ISSN: , DOI:
27th NBTE Annual Meeting 2018 2019-10-08
2018 Stein, F.; Trikalitis, V.; Feitosa-Afonsso, D.M.; Rouwkema, J.
Characterization of cell spheroids as promising tool as 3D printable building blocks for vascular network formation
published pages: , ISSN: , DOI:
27th NBTE Annual Meeting 2018 2019-10-08
2018 Rana, D.; Salehi Nik, N.; Rouwkema, J.
Programmable Release of Vascular Endothelial Growth Factor for Vascularization in Engineered Tissues
published pages: , ISSN: , DOI:
27th NBTE Annual Meeting 2018 2019-10-08
2019 Rana, D.; Salehi Nik, N.; Rouwkema, J.
Designing Programmable Hydrogels for Controlled Vessel Formation within Engineered Tissues
published pages: 951, ISSN: , DOI:
TERMIS European Chapter Meeting 2019: Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation 2019-10-08
2018 Zhang, J.; Padmanaban, P.; Rouwkema, J.
Controlling Vascularisation Within Tissue Building Blocks Using Internal and External Mechanical Cues
published pages: , ISSN: , DOI:
NBTE annual meeting 2018 2019-10-08
2019 Rana, D.; Salehi Nik, N.; Rouwkema, J.
Towards Controlling Vascularization within Engineered Tissues via Programmable Hydrogels
published pages: , ISSN: , DOI:
Aptamers in Bordeaux 2019: International Conference on Aptamer Biology, Chemistry, Technologies & Therapeutics 2019-10-08
2019 Padmanaban, P.; Chizari, A.; Steenbergen, W.; Rouwkema, J.
Modification of mechanical environment to control vascular organization within developing chicken embryo
published pages: , ISSN: , DOI:
TERMIS European Chapter Meeting 2019: Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation 2019-10-08
2019 Salehi Nik, N.; Sayedipour, S.S.; Padmanaban, P.; Stein, F.; Rouwkema, J.
What Controls Endothelial Sprouting? Interstitial Flow vs. Shear Stress
published pages: , ISSN: , DOI:
TERMIS European Chapter Meeting 2019: Tissue Engineering Therapies: From Concept to Clinical Translation & Commercialisation 2019-10-08
2018 Padmanaban, P.; Chizari, A.; Steenbergen, W.; Rouwkema, J.
Inside the box: 3D system to probe the vascular networks within developing chicken embryo
published pages: , ISSN: , DOI:
27th NBTE Annual Meeting 2018 2019-10-08
2019 Rana, D.; Salehi Nik, N.; Rouwkema, J.
Towards Spatiotemporally Controlled Vascular Network Formation within Engineered Tissues
published pages: , ISSN: , DOI:
Biofabrication & Biomanufacturing Europe 2019 : SelectBio 2019-10-08
2017 Rana, D.; Rouwkema, J.
Vasculogenic Hydrogel: A Potential Substrate for Growth Factor Localization in Multi-Structural Tissue Engineering
published pages: , ISSN: , DOI:
The Netherlands Society for Biomaterials and Tissue Engineering 26th Annual Meeting 2019-04-18
2018 Padmanaban, P.; Rouwkema, J.
Roadmap for predicting vascular organization within engineered tissues
published pages: , ISSN: , DOI:
EMBO Workshop on Physics of integrated biological systems 2018 2019-04-18
2018 Stein, F.; Salehi Nik, N.; Padmanaban, P.; Rouwkema, J.
The role of mechanical environment in regulating vascular network formation
published pages: , ISSN: , DOI:
8th World Congress of Biomechanics 2018 2019-04-18
2017 Trikalitis, V.; Salehi Nik, N.; Rouwkema, J.
Blood Vessel Model using Tissue Modules with on-demand Stimuli
published pages: , ISSN: , DOI:
ISSUE=26;TITLE=The Netherlands Society for Biomaterials and Tissue Engineering 26th Annual Meeting, 2017 1 2019-04-18
2017 Stein, F.; Trenti, Chiara; Salehi Nik, N.; Rouwkema, J.
Effect of fluid flow on vascular network organization in a multi-structural in vitro model
published pages: , ISSN: , DOI:
ISSUE=26;TITLE=The Netherlands Society for Biomaterials and Tissue Engineering 26th Annual Meeting, 2017 1 2019-04-18
2018 Trikalitis, V.; Stein, F.; Perea Paizal, J.; Salehi Nik, N.; Rouwkema, J.
Towards Vascularized Tissue Blocks Using a Suspension Bioprinted Blood Vessel
published pages: , ISSN: , DOI:
5th TERMIS World Congress 2018 2019-04-18

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The information about "VASCARBOR" are provided by the European Opendata Portal: CORDIS opendata.

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