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BARCODE DIAGNOSTICS SIGNED

Next-Generation Personalized Diagnostic Nanotechnologies for Predicting Response to Cancer Medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 BARCODE DIAGNOSTICS project word cloud

Explore the words cloud of the BARCODE DIAGNOSTICS project. It provides you a very rough idea of what is the project "BARCODE DIAGNOSTICS" about.

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Project "BARCODE DIAGNOSTICS" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country Israel [IL]
 Project website https://www.schroederlab.com/
 Total cost 1˙499˙250 €
 EC max contribution 1˙499˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 1˙499˙250.00

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 Project objective

Cancer is the leading cause of death in the Western world and the second cause of death worldwide. Despite advances in medical research, 30% of cancer patients are prescribed a medication the tumor does not respond to, or, alternatively, drugs that induce adverse side effects patients' cannot tolerate. Nanotechnologies are becoming impactful therapeutic tools, granting tissue-targeting and cellular precision that cannot be attained using systems of larger scale. In this proposal, I plan to expand far beyond the state-of-the-art and develop a conceptually new approach in which diagnostic nanoparticles are designed to retrieve drug-sensitivity information from malignant tissue inside the body. The ultimate goal of this program is to be able to predict, ahead of time, which treatment will be best for each cancer patient – an emerging field called personalized medicine. This interdisciplinary research program will expand our understandings and capabilities in nanotechnology, cancer biology and medicine. To achieve this goal, I will engineer novel nanotechnologies that autonomously maneuver, target and diagnose the various cells that compose the tumor microenvironment and its disseminated metastasis. Each nanometric system will contain a miniscule amount of a biologically-active agent, and will serve as a nano lab for testing the activity of the agents inside the tumor cells. To distinguish between system to system, and to grant single-cell sensitivity in vivo, nanoparticles will be barcoded with unique DNA fragments. We will enable nanoparticle' deep tissue penetration into primary tumors and metastatic microenvironments using enzyme-loaded particles, and study how different agents, including small-molecule drugs, proteins and RNA, interact with the malignant and stromal cells that compose the cancerous microenvironments. Finally, we will demonstrate the ability of barcoded nanoparticles to predict adverse, life-threatening, side effects, in a personalized manner.

 Publications

year authors and title journal last update
List of publications.
2019 Omer Adir, Maria Poley, Gal Chen, Sahar Froim, Nitzan Krinsky, Jeny Shklover, Janna Shainsky‐Roitman, Twan Lammers, Avi Schroeder
Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine
published pages: 1901989, ISSN: 0935-9648, DOI: 10.1002/adma.201901989
Advanced Materials 2019-08-29
2019 Hanan Abumanhal-Masarweh, Dana da Silva, Maria Poley, Assaf Zinger, Evgenya Goldman, Nitzan Krinsky, Ron Kleiner, Gal Shenbach, Josh E. Schroeder, Jeny Shklover, Janna Shainsky-Roitman, Avi Schroeder
Tailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells
published pages: 331-341, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.06.025
Journal of Controlled Release 307 2019-08-29
2018 Dana da Silva, Maya Kaduri, Maria Poley, Omer Adir, Nitzan Krinsky, Janna Shainsky-Roitman, Avi Schroeder
Biocompatibility, biodegradation and excretion of polylactic acid (PLA) in medical implants and theranostic systems
published pages: 9-14, ISSN: 1385-8947, DOI: 10.1016/j.cej.2018.01.010
Chemical Engineering Journal 340 2019-04-18
2016 Nitzan Krinsky, Maya Kaduri, Janna Shainsky-Roitman, Mor Goldfeder, Eran Ivanir, Itai Benhar, Yuval Shoham, Avi Schroeder
A Simple and Rapid Method for Preparing a Cell-Free Bacterial Lysate for Protein Synthesis
published pages: e0165137, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0165137
PLOS ONE 11/10 2019-06-19
2016 Zvi Yaari, Dana da Silva, Assaf Zinger, Evgeniya Goldman, Ashima Kajal, Rafi Tshuva, Efrat Barak, Nitsan Dahan, Dov Hershkovitz, Mor Goldfeder, Janna Shainsky Roitman, Avi Schroeder
Theranostic barcoded nanoparticles for personalized cancer medicine
published pages: 13325, ISSN: 2041-1723, DOI: 10.1038/ncomms13325
Nature Communications 7 2019-06-19
2017 Evgeniya Goldman, Assaf Zinger, Dana da Silva, Zvi Yaari, Ashima Kajal, Dikla Vardi-Oknin, Mor Goldfeder, Josh E. Schroeder, Janna Shainsky-Roitman, Dov Hershkovitz, Avi Schroeder
Nanoparticles target early-stage breast cancer metastasis in vivo
published pages: 43LT01, ISSN: 0957-4484, DOI: 10.1088/1361-6528/aa8a3d
Nanotechnology 28/43 2019-06-19

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