Opendata, web and dolomites

STARS SIGNED

Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

concentration    impacting    signature    treat    progression    prevent    attenuation    onset    published    cancer    diabetes    d2    data    catabolism    skeletal    endocrine    attenuated    biology    levels    dissect    preliminary    identification    heart    proof    determines    discover    mechanism    disciplinary    despite    atrophy    amplified    local    enzymes    treatments    explore    breaking    ground    d3    tissue    chronic    implications    lower    facilitates    proliferation    muscle    regardless    complication    action    causes    medical    prevention    survival    acting    conjugates    altered    urgent    active    diseases    devastating    decrease    contrary    critical    nature    metabolism    accelerated    wasting    signal    reduces    models    amplification    signalling    functions    plasma    possibility    methodology    manipulating    cells    stars    hormone    myopathies    therapy    fibers    peptide    attempt    mechanisms    ageing    cell    mouse    diffuse    fibrosis    healthy    therapeutic    determinant    cross    thyroid    disease    dysfunctions    genetically    stem    actions    hypothesis    manipulated    cystic    deiodinase    pleiotropic   

Project "STARS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙310˙000.00

Map

 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STARS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More