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STARS SIGNED

Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €

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EC-Contrib. €

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Partnership

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 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

attempt    therapeutic    cancer    manipulated    ageing    attenuation    diffuse    hormone    impacting    nature    proliferation    action    cystic    preliminary    discover    amplified    breaking    urgent    metabolism    survival    peptide    tissue    diabetes    signalling    cross    dissect    prevent    disease    active    reduces    regardless    acting    progression    myopathies    hypothesis    functions    causes    treatments    implications    catabolism    contrary    genetically    data    endocrine    identification    fibers    mechanism    d3    determinant    ground    conjugates    prevention    muscle    enzymes    atrophy    plasma    cells    heart    dysfunctions    accelerated    complication    devastating    mechanisms    determines    biology    altered    cell    treat    signal    actions    despite    concentration    medical    mouse    d2    skeletal    explore    wasting    diseases    healthy    methodology    published    pleiotropic    deiodinase    stars    therapy    critical    possibility    manipulating    models    attenuated    proof    levels    amplification    local    stem    facilitates    lower    decrease    signature    thyroid    disciplinary    fibrosis    chronic    onset   

Project "STARS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙310˙000.00

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 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

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The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

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