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STARS SIGNED

Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €

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EC-Contrib. €

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Partnership

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 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

data    hypothesis    ground    concentration    complication    cell    lower    published    altered    dissect    thyroid    treat    endocrine    devastating    hormone    stem    proliferation    acting    urgent    identification    preliminary    fibrosis    ageing    deiodinase    cancer    d2    treatments    impacting    diseases    mechanism    biology    signature    healthy    despite    wasting    facilitates    cells    pleiotropic    manipulating    survival    regardless    chronic    prevent    discover    dysfunctions    breaking    explore    local    stars    therapeutic    critical    attenuation    diffuse    mouse    attenuated    action    models    conjugates    accelerated    medical    fibers    mechanisms    possibility    disease    decrease    functions    attempt    actions    skeletal    reduces    genetically    prevention    implications    signalling    disciplinary    causes    determines    cross    cystic    peptide    metabolism    heart    contrary    onset    catabolism    signal    methodology    d3    atrophy    muscle    plasma    enzymes    progression    tissue    determinant    active    nature    proof    amplification    levels    therapy    manipulated    amplified    diabetes    myopathies   

Project "STARS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙310˙000.00

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 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

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The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

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