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STARS SIGNED

Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €

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EC-Contrib. €

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Partnership

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 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

accelerated    local    complication    skeletal    fibers    ageing    identification    lower    active    onset    causes    disciplinary    published    peptide    models    diabetes    methodology    survival    cross    explore    possibility    treatments    actions    functions    action    determines    amplification    dissect    diseases    impacting    prevention    cell    discover    wasting    concentration    myopathies    signal    data    atrophy    plasma    despite    manipulated    amplified    progression    d3    prevent    thyroid    nature    implications    biology    stars    catabolism    genetically    metabolism    ground    cells    mouse    cystic    therapy    d2    facilitates    attenuated    medical    treat    acting    mechanisms    endocrine    heart    stem    attempt    reduces    critical    fibrosis    contrary    deiodinase    healthy    altered    therapeutic    enzymes    regardless    disease    hormone    hypothesis    proliferation    signalling    devastating    decrease    manipulating    pleiotropic    cancer    conjugates    diffuse    signature    breaking    proof    mechanism    urgent    tissue    muscle    chronic    preliminary    determinant    levels    attenuation    dysfunctions   

Project "STARS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙310˙000.00

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 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

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The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

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