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STARS SIGNED

Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €

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EC-Contrib. €

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Partnership

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 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

pleiotropic    hormone    manipulating    proof    proliferation    treatments    functions    action    thyroid    critical    mouse    medical    enzymes    survival    discover    wasting    concentration    complication    reduces    conjugates    cell    lower    disciplinary    therapy    stars    hypothesis    signal    prevent    fibrosis    cells    nature    contrary    preliminary    myopathies    muscle    biology    accelerated    fibers    peptide    d3    atrophy    tissue    chronic    actions    prevention    published    therapeutic    facilitates    amplified    skeletal    catabolism    disease    attempt    metabolism    stem    cross    models    cystic    mechanism    dissect    diabetes    d2    data    despite    determinant    implications    attenuation    devastating    manipulated    impacting    diffuse    attenuated    treat    explore    possibility    altered    heart    breaking    deiodinase    identification    signalling    cancer    regardless    endocrine    local    levels    genetically    healthy    causes    onset    progression    determines    signature    methodology    amplification    plasma    acting    dysfunctions    decrease    ground    diseases    ageing    active    mechanisms    urgent   

Project "STARS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II 

Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138
website: www.unina.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) coordinator 1˙310˙000.00

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 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

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The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

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