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Strategies Targeting Thyroid Hormone in Athrophy Related Syndromes

Total Cost €


EC-Contrib. €






 STARS project word cloud

Explore the words cloud of the STARS project. It provides you a very rough idea of what is the project "STARS" about.

implications    determinant    dissect    regardless    fibers    signalling    attenuated    deiodinase    local    discover    endocrine    action    enzymes    published    cancer    functions    treat    impacting    attempt    contrary    manipulating    plasma    heart    d2    metabolism    lower    amplified    actions    nature    altered    ageing    critical    treatments    determines    peptide    models    medical    diffuse    disciplinary    signature    muscle    active    disease    accelerated    identification    myopathies    therapeutic    biology    thyroid    urgent    diabetes    mechanism    pleiotropic    survival    concentration    tissue    genetically    facilitates    attenuation    cells    cross    prevention    signal    catabolism    skeletal    cystic    preliminary    mechanisms    acting    breaking    chronic    mouse    stars    ground    despite    cell    devastating    proof    data    dysfunctions    onset    d3    stem    explore    methodology    diseases    wasting    prevent    hormone    levels    hypothesis    manipulated    amplification    reduces    progression    healthy    decrease    complication    proliferation    therapy    causes    atrophy    fibrosis    possibility    conjugates   

Project "STARS" data sheet

The following table provides information about the project.


Organization address
address: CORSO UMBERTO I, 40
city: NAPOLI
postcode: 80138

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙310˙000 €
 EC max contribution 1˙310˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Skeletal muscle wasting is a devastating complication of many chronic diseases including cancer, diabetes, chronic heart failure and cystic fibrosis. Despite its medical importance, there is, as yet, no effective means to treat this condition. Therefore, an urgent challenge is to discover treatments able to prevent its onset and/or progression. Thyroid hormone (TH) is a major determinant of muscle functions, and thyroid dysfunctions are leading causes of many myopathies. An emerging concept in this field is that TH’s pleiotropic actions can be amplified or attenuated at cell level by the deiodinase enzymes that can increase (D2) or decrease (D3) the active TH concentration regardless of hormone plasma levels. Based on recent published and new preliminary data, our working hypothesis is that “amplification” of TH action/signalling in muscle is critical in determining the accelerated muscle catabolism that causes muscle loss in numerous diseases. On the contrary, attenuation of the TH signal facilitates the proliferation/survival of muscle stem cells and reduces atrophy. Using genetically manipulated mouse models of altered TH metabolism, STARS aims to dissect the role of TH in muscle fibers and stem cells during the wasting processes. The ground-breaking nature of STARS is the possibility of manipulating a local-acting mechanism that determines the tissue concentration of a diffuse endocrine signal (TH), which is a critical determinant of muscle wasting. We will use state-of-the art methodology and recently generated mouse models in the attempt to explore the therapeutic potential of novel mechanisms to lower the TH signature at a specific muscle level. Proof-of-principle studies will be conducted with novel hormone-peptide conjugates for targeted disease prevention and therapy. The results will have cross-disciplinary implications, for the identification of novel potential therapeutic approaches impacting on stem cell biology, tissue metabolism and healthy ageing.

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The information about "STARS" are provided by the European Opendata Portal: CORDIS opendata.

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