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Investigating the regulation of iron homeostasis by erythroferrone and therapeutic applications

Total Cost €


EC-Contrib. €






 INVESTIGERFE project word cloud

Explore the words cloud of the INVESTIGERFE project. It provides you a very rough idea of what is the project "INVESTIGERFE" about.

delineating    treatment    murine    red    regulators    1950s    anemias    antagonist    leads    cells    regulator    intensifies    benefits    mechanism    hepcidin    antagonization    suppressed    bowel    erythron    prerequisite    search    erfe    chronic    existence    hormone    erythroferrone    kidney    mouse    tremendous    abortus    infections    identification    thalassemias    disorders    confirmed    thalassemia    regulatory    blood    molecules    erythroid    triggered    contribution    receptor    stores    restricted    opened    therapies    suppresses    recovery    meet    model    inflammatory    levels    manipulation    mice    anemia    release    beta    showed    cancer    envision    models    biomedical    secondary    proof    homeostasis    signaling    synthesis    independent    therapy    first    treatments    overload    human    assay    axes    rheumatoid    advantage    sought    disease    frequent    pathologies    action    loading    thalassemic    examine    ineffective    iron    absorption    agonist    arthritis   

Project "INVESTIGERFE" data sheet

The following table provides information about the project.


Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙499˙235 €
 EC max contribution 1˙499˙235 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The existence of an “erythron-related regulator” that intensifies iron absorption and its release from stores to meet the requirements for red blood cells synthesis was proposed in the 1950s. Delineating this mechanism is of high biomedical importance as the pathway could be targeted to develop novel treatments for iron-restricted anemias that are very frequent but for which current therapies are ineffective (e.g. infections, inflammatory bowel disease, cancer, or chronic kidney disease) and for iron-loading anemias (e.g. thalassemias). We have recently identified the hormone erythroferrone (ERFE) and showed that it could be the long-sought erythroid regulator of iron homeostasis. ERFE suppresses the synthesis of the iron-regulatory hormone hepcidin to facilitate the recovery from anemia but leads to secondary iron overload in β-thalassemia. The potential of ERFE in the treatment of iron disorders is tremendous but understanding its mechanism of action is a prerequisite to envision ERFE-based therapies. The identification of ERFE has opened new research areas and our project will be organized around four axes. 1) Develop an assay to measure ERFE levels in human pathologies. Its contribution is not known and needs to be confirmed. 2) Identify the receptor for ERFE, the signaling pathways triggered by ERFE, and molecules with agonist/antagonist effects, a prerequisite in the development of new therapies. 3) Search for potential other erythroid regulators. We will take advantage of the Erfe-/- mice to determine whether hepcidin could be suppressed by an ERFE-independent mechanism. 4) Study the potential of ERFE manipulation in therapy in the mouse. We will first establish a proof of principle in a mouse model of anemia (B. abortus). The benefits of ERFE antagonization will be addressed in thalassemic mice. We will also examine the role of ERFE in murine models of chronic anemia: chronic kidney disease, inflammatory bowel disease, rheumatoid arthritis and infections.


year authors and title journal last update
List of publications.
2019 Sabrina Bondu, Anne-Sophie Alary, Carine Lefèvre, Alexandre Houy, Grace Jung, Thibaud Lefebvre, David Rombaut, Ismael Boussaid, Abderrahmane Bousta, François Guillonneau, Prunelle Perrier, Samar Alsafadi, Michel Wassef, Raphaël Margueron, Alice Rousseau, Nathalie Droin, Nicolas Cagnard, Sophie Kaltenbach, Susann Winter, Anne-Sophie Kubasch, Didier Bouscary, Valeria Santini, Andrea Toma, Mathild
A variant erythroferrone disrupts iron homeostasis in SF3B1 -mutated myelodysplastic syndrome
published pages: eaav5467, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aav5467
Science Translational Medicine 11/500 2020-01-30
2019 Irene Artuso, Mariateresa Pettinato, Antonella Nai, Alessia Pagani, Ugo Sardo, Benjamin Billoré, Maria Rosa Lidonnici, Cavan Bennett, Giacomo Mandelli, Sant-Rayn Pasricha, Giuliana Ferrari, Clara Camaschella, Léon Kautz, Laura Silvestri
Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice
published pages: e87-e90, ISSN: 0390-6078, DOI: 10.3324/haematol.2018.199810
Haematologica 104/3 2020-01-30

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