MITOMAR

The mitochondrial mono-ADP-ribosylation landscape

 Coordinatore LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Corey
Cognome: Laverty
Email: send email
Telefono: +49 89218077096
Fax: +49 89218077093

 Nazionalità Coordinatore Germany [DE]
 Totale costo 161˙968 €
 EC contributo 161˙968 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2013-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-04-01   -   2016-06-23

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Dr.
Nome: Corey
Cognome: Laverty
Email: send email
Telefono: +49 89218077096
Fax: +49 89218077093

DE (MUENCHEN) coordinator 161˙968.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

ribosylation    mechanisms    mono    networks    adp    ribosyl    health    environment    mitomar    cancer    proteins    metabolism    diseases    neurodegenerative    life    disorders    responsive    mitochondrial   

 Obiettivo del progetto (Objective)

'Metabolism sustains life, providing the right amount of energy to keep the body active and responsive to a changing environment. Abnormal metabolism is at the heart of many health problems, including cancer, neurodegenerative disorders and diabetes, which severely affect an individual’s quality of life and have become high priorities for Europe. Our understanding of the mechanisms that underlie these diseases has rapidly evolved over recent years. Yet, the development of novel, effective interventions still requires the further identification and analysis of mechanistically ill-understood, but physiologically important molecular mechanisms and signaling networks.

The MitoMAR project dissects mitochondrial mono-ADP-ribosylation, a highly dynamic, environment-responsive post-translational modification of cellular proteins, which links changes in mitochondrial function and NAD production to the aetiology of these diseases. We are studying the mitochondrial ADP-ribosyl-proteome under a variety of growth conditions and will describe the biological role of mitochondrial ADP-ribosylation for a subset of modified targets, characterizing their interaction with mitochondrial ADP-ribosyl polymerases and hydrolases

Evidence indicates that ADP-ribosylation biology underlies the pathomechanisms of cancer, neurodegenerative and metabolic disorders. The main aim of the MitoMAR project is to advance our understanding of the proteins and networks that are modulated by mitochondrial mono-ADP-ribosylation. Considering the central role of mitochondria and metabolism in human health, the expected results will be immediately useful to other researchers, and will ultimately facilitate the development of therapeutic approaches by identifying new drug targets.'

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