Opendata, web and dolomites

TRACERxTME SIGNED

Constructing an evolutionary atlas of the immune landscape in lung cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "TRACERxTME" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The immune system imposes a continuous selective pressure that influences the evolutionary trajectories of tumour cell populations. The interplay between evolving genetics of tumour cells and the corresponding immune response is poorly understood. A deeper understanding of tumour microenvironmental constraints upon cancer evolution may define an evolutionary rulebook and help to inform the rational and personalized design of combination immunotherapies for the treatment of cancer. In this study, we aim to integrate detailed genomic information from the TRACERx lung cancer cohort (TRAcking lung Cancer Evolution through therapy (Rx), a multiregion longitudinal study aiming to study >5000 tumour regions from 842 patients) with highly multiplexed tumour microenvironment imaging mass cytometry data in order to decipher the dynamics of distinct microenvironmental cell types during the disease course and tentatively begin to construct the rulebook of cancer. We will characterize how the tumour genome and microenvironment evolves throughout the disease course by analyzing multiregion tumour samples taken at time of surgery, relapse and death through the fast-autopsy PEACE study (Posthumous Evaluation of Advanced Cancer Environment). Successful completion of these aims will generate the most complete understanding of the lung tumour microenvironment to date within the contexture of the evolving tumour genome. This knowledge will ultimately inform the design of innovative precision medicine strategies in lung cancer.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRACERXTME" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRACERXTME" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

RegARcis (2020)

Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation

Read More