Opendata, web and dolomites

ChroSoDSB

Chromatin Study of DNA Double Strand Breaks

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ChroSoDSB project word cloud

Explore the words cloud of the ChroSoDSB project. It provides you a very rough idea of what is the project "ChroSoDSB" about.

constantly    performing    chromatin    belief    contrast    strand    pathological    mutagenic    modification    independence    ddr    overcome    implicated    exclusively    genomic    onset    architecture    heterogeneous    intricate    containing    local    purification    powerful    ways    subsequently    dsb    dsbs    complexes    characterise    appropriate    safe    though    scientific    functionally    breaks    regulators    restoration    cancer    collectively    select    damage    chromatinised    career    true    similarly    vital    significantly    remodelling    random    either    intact    progressed    lesions    cytotoxic    de    assemble    keep    euchromatin    perils    multidisciplinary    induce    repair    chromosomal    context    arguably    status    compartment    protein    stark    comprised    generation    transferrable    mechanisms    obtain    skills    starting    distributed    dna    cellular    hurdle    downstream    prevent    validate    protective    located    encounters    huge    heterochromatin    signalling    proteins    facto    premature    ageing    regulating    factories    behave    scaffolding    life    environment    combining    branch    double    instability    interplay    limited   

Project "ChroSoDSB" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.cpr.ku.dk/research/proteinsignaling/mailand/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

In stark contrast to common belief, cellular DNA is not de facto safe as it constantly encounters numerous perils. To keep chromosomal DNA intact and to prevent the onset of pathological conditions, such as cancer and premature ageing, which are driven by DNA damage-induced genomic instability, life has evolved appropriate protective mechanisms, collectively referred to as the DNA Damage Response (DDR). A vital branch of the DDR is the response to DNA double-strand breaks (DSBs), arguably the most cytotoxic and mutagenic lesions. DSBs lead to the modification of their local chromatin environment to allow scaffolding of downstream protein factories, comprised of signalling, chromatin remodelling and DNA repair proteins. These DSB processing factories assemble in the context of chromatinised DNA, making chromatin architecture crucial for DSB restoration. Though our understanding of how chromatin status affects the DSB response has significantly progressed in recent years, we are only starting to identify factors regulating this intricate interplay. Moreover, current ways to induce DSB result in random, heterogeneous DNA damage, therefore not allowing the study of the DSB response in a specific chromatin compartment. In order to overcome this technical hurdle and to identify new regulators of DSB signalling and repair, I will use a powerful new method, combining the generation of limited, well-distributed DSBs, exclusively located in either euchromatin or heterochromatin, with specific purification of DSB-containing chromatin protein-complexes. Subsequently, I will select, validate and functionally characterise novel factors that have not yet been implicated in the DSB response, but behave similarly to known DSB-related proteins. By performing this multidisciplinary project, I will obtain new scientific and transferrable skills, thus taking a huge step towards true scientific independence and better career opportunities.

 Publications

year authors and title journal last update
List of publications.
2018 Peter Haahr, Nikoline Borgermann, Xiaohu Guo, Dimitris Typas, Divya Achuthankutty, Saskia Hoffmann, Robert Shearer, Titia K. Sixma, Niels Mailand
ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability
published pages: 165-174.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.02.024
Molecular Cell 70/1 2019-11-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHROSODSB" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHROSODSB" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

DiMaS (2019)

Retrospective genomic analyses of shortfin Mako shark (Isurus oxyrinchus) using DNA from archived jaws

Read More