Opendata, web and dolomites

LamelliActin

Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LamelliActin project word cloud

Explore the words cloud of the LamelliActin project. It provides you a very rough idea of what is the project "LamelliActin" about.

migrating    mechanisms    elongation    generate    protrusion    artificial    environments    context    filament    ultimately    combination    employing    filaments    immune    lamellipodial    front    multicellular    misguided    single    directional    engineered    underlying    view    relevance    ultrastructural    generating    living    resolution    prototypic    tissues    technically    suggests    cells    crosslinking    biological    constraints    challenged    diseases    molecular    surveillance    physical    electron    biology    decision    regeneration    decipher    actin    circumnavigation    correlative    direct    genetic    structure    flat    adaptations    accordingly    extracellular    microfluidics    fluorescence    mechanical    substrate    combined    obstacles    developmental    networks    migrate    immunology    negotiate    tomography    pathogenesis    contributes    cell    depolymerization    biophysical    sheet    coordinate    matrix    micropatterning    questions    socioeconomic    force    quantitative    principles    cardiovascular    inflammation    lamellipodium    nucleation    fundamental    dendritic    clinical    centrally    embryonic    biophysics    chronic    cancer    multidisciplinary    migration    integrate   

Project "LamelliActin" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://ist.ac.at/research/research-groups/sixt-group/lamelliactin/
 Total cost 178˙156 €
 EC max contribution 178˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGYAUSTRIA AT (KLOSTERNEUBURG) coordinator 178˙156.00

Map

 Project objective

Cell migration is centrally involved in embryonic development, regeneration and immune surveillance. However, when misguided it also contributes to the pathogenesis of Europe’s socioeconomic most relevant diseases including cancer, cardiovascular diseases and chronic inflammation. Accordingly, better understanding the fundamental mechanisms of cell migration is of direct clinical relevance. In order to migrate within a multicellular context, cells have to negotiate physical constraints, such as other cells and the extracellular matrix and effectively integrate mechanical challenges into directional decision-making. This proposal suggests a combined cell biological and biophysical approach to provide a quantitative understanding of the underlying molecular and mechanical principles. We will focus on the prototypic force-generating structure of migrating cells the lamellipodium - a flat sheet-like protrusion of dendritic actin networks at the leading front of migrating cells. We will decipher the ultrastructural adaptations of lamellipodial actin networks with single filament resolution and characterize how nucleation, elongation, depolymerization and crosslinking of actin filaments coordinate circumnavigation of mechanical obstacles. Technically, these questions will be addressed in a multidisciplinary approach by employing correlative fluorescence and electron tomography in combination with artificial environments engineered using microfluidics and substrate micropatterning, as well as genetic approaches and biological modelling. Importantly, findings will ultimately be challenged in living tissues. The expected results will generate an integrated view of force-adaptations of actin networks in living cells and will not only impact the fields of cell biology and biophysics but also cancer biology, immunology and developmental biology.

 Publications

year authors and title journal last update
List of publications.
2018 Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner, Jun Abe, Jörg Renkawitz, Jens V. Stein, Michael Sixt
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
published pages: 606-616, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0109-z
Nature Immunology 19/6 2019-09-02
2017 Florian Gaertner, Zerkah Ahmad, Gerhild Rosenberger, Shuxia Fan, Leo Nicolai, Benjamin Busch, Gökce Yavuz, Manja Luckner, Hellen Ishikawa-Ankerhold, Roman Hennel, Alexandre Benechet, Michael Lorenz, Sue Chandraratne, Irene Schubert, Sebastian Helmer, Bianca Striednig, Konstantin Stark, Marek Janko, Ralph T. Böttcher, Admar Verschoor, Catherine Leon, Christian Gachet, Thomas Gudermann, Michael Mederos y Schnitzler, Zachary Pincus, Matteo Iannacone, Rainer Haas, Gerhard Wanner, Kirsten Lauber, Michael Sixt, Steffen Massberg
Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria
published pages: 1368-1382.e23, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.11.001
Cell 171/6 2019-09-02
2018 Shuxia Fan, Michael Lorenz, Steffen Massberg, Florian Gaertner
Platelet Migration and Bacterial Trapping Assay under Flow
published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3018
BIO-PROTOCOL 8/18 2019-09-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LAMELLIACTIN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LAMELLIACTIN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MathematicsAnalogies (2019)

Mathematics Analogies

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

FOCUSIS (2020)

Focal volume Control Using Structured Illumination Sources

Read More