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3DQuant

Understanding long-range transcriptional regulation in the context of the 3D genome organization

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 3DQuant project word cloud

Explore the words cloud of the 3DQuant project. It provides you a very rough idea of what is the project "3DQuant" about.

engineered    distances    contributes    techniques    partitioned    topologically    influences    chromosomes    measured    outputs    partitioning    regulatory    spatial    promoter    embryonic    cognate    cell    sub    expression    physical    unprecedented    space    environment    live    loops    transcriptional    conformation    modulate    enhancers    genetic    metazoans    architecture    capture    shown    domains    dimensional    underlying    unknown    suggests    unravel    mechanisms    correlated    enhancer    3c    precisely    quantitatively    genes    generate    chromosome    single    action    linked    3d    pairs    technologies    self    promoters    proximity    transcription    modulation    close    organization    measuring    genome    gene    megabase    mechanism    communication    folded    regulation    imaging    patterns    chromatin    tads    structure    engineering    establishment    mobilized    temporal    manner    interactions    isolated    modulates    mouse    quantitative    view    cells    relationship    genomic    stem    mammalian    mediated    associating    biophysical   

Project "3DQuant" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 175˙419.00

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 Project objective

Enhancers are regulatory elements that control the spatial and temporal expression of genes in metazoans. Enhancers are able to modulate transcription of a target gene from large genomic distances, as a result of the formation of chromatin loops that bring them in close spatial proximity to cognate promoters. The manner how specific patterns of enhancer-promoter physical interactions are established is linked to how chromosomes are folded in the three-dimensional (3D) space. Recent studies based on chromosome conformation capture (3C) have shown that mammalian chromosomes are partitioned into self-associating sub-megabase domains called Topologically Associating Domains (TADs). Genetic evidence suggests that 3D chromatin organization within and across TADs contributes to the establishment and partitioning of enhancers-promoters physical communication. Yet it is still unknown by which biophysical mechanisms chromosome architecture modulates enhancer action, and thus transcription. The goal of this proposal is to determine the quantitative relationship between 3D chromatin architecture and enhancer-promoter activity to unravel the mechanism of long-range transcriptional modulation mediated by enhancers. Addressing this goal requires a system where transcriptional outputs can be measured precisely and quantitatively, and correlated with 3D distances. To this aim, we will use state-of-the art genome engineering techniques to generate mouse embryonic stem cells with engineered enhancer-promoter pairs in an isolated chromatin environment, where a selected enhancer can be mobilized at different distances from its cognate promoter. We will use this system to quantitatively assess how 3D chromatin structure influences enhancer action by measuring transcription and promoter-enhancer interactions using 3C-based technologies, single-cell methods and live-cell imaging. This will lead to an unprecedented view of the mechanisms underlying long-range transcriptional regulation.

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