Explore the words cloud of the ROSALIND project. It provides you a very rough idea of what is the project "ROSALIND" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||1˙500˙000.00|
Cardiovascular disease (CVD) is under-diagnosed and under-investigated specifically in women. Clinical presentation of CVD is often different in women and the aetiology of some diseases is potentially triggered by specific female sex environmental factors (e.g hormonal cycles and pregnancy) and could result in a distinct physiopathology from men. This may apply to fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD), two devastating arterial diseases that share clinical features, which are non-atherosclerotic stenosis of medium-size arteries (renal and/or cerebrovascular arteries in FMD, coronary artery in SCAD) and an age of onset under 50, in addition to a high proportion of female patients (75-90%). In addition, genetic predisposing factors may interact with the female specific context and disturb the artery structure and/or function resulting in a female specific propensity to these CVDs. The ROSALIND project aims to: 1) Decipher the genetic basis of FMD and SCAD using genome-wide association in case control cohorts; 2) Examine the functional significance of the genetic susceptibility variants at confirmed loci and their targeted genes using high throughput NGS-based genomic methods and 3) explore the link of genes in FMD susceptibility loci with vascular function by the analyses of engineered cell lines and total expression in human renal arteries. This project will provide an unprecedented resource of genetic, gene expression and functional genomics data that will be instrumental to guide the uncovering of new genes and mechanisms involved in FMD and SCAD. This project will help better understand the physiopathology and shed light on novel and promising therapeutic targets for the non-atherosclerotic arterial stenosis that characterize these female CVDs
|year||authors and title||journal||last update|
Angela H.E.M. Maas, Nabila Bouatia-Naji, Alexandre Persu, David Adlam
Spontaneous coronary artery dissections and fibromuscular dysplasia: Current insights on pathophysiology, sex and gender
published pages: 220-225, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2018.11.023
|International Journal of Cardiology 286||2019-10-29|
Adrien Georges, Nabila Bouatia-Naji
La gÃ©nÃ©tique Ã©tablit le lien entre plusieurs maladies cardiovasculaires affectant prÃ©fÃ©rentiellement les femmes
published pages: 605-607, ISSN: 0767-0974, DOI: 10.1051/medsci/2019119
David Adlam, Timothy M. Olson, Nicolas Combaret, Jason C. Kovacic, Siiri E. Iismaa, Abtehale Al-Hussaini, Megan M. O\'Byrne, Sara Bouajila, Adrien Georges, Ketan Mishra, Peter S. Braund, Valentina dâ€™Escamard, Siying Huang, Marios Margaritis, Christopher P. Nelson, Mariza de Andrade, Daniella Kadian-Dodov, Catherine A. Welch, Stephani Mazurkiewicz, Xavier Jeunemaitre, Claire Mei Yi Wong, Eleni Gia
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
published pages: 58-66, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2018.09.085
|Journal of the American College of Cardiology 73/1||2019-10-29|
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