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ROSALIND SIGNED

Investigating fibROmuscular dysplasia and spontaneous coronary Artery dissection using genetic and functionaL genomics to decipher the origIN of two female specific cardiovascular Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ROSALIND project word cloud

Explore the words cloud of the ROSALIND project. It provides you a very rough idea of what is the project "ROSALIND" about.

presentation    examine    loci    function    dysplasia    significance    proportion    ngs    lines    association    stenosis    patients    cohorts    functional    disease    shed    ing    hormonal    interact    link    genomic    sex    pregnancy    men    throughput    cardiovascular    spontaneous    engineered    women    cycles    diseases    environmental    human    artery    cvds    guide    arteries    scad    decipher    light    genome    genes    fmd    genomics    75    variants    disturb    share    uncovering    susceptibility    vascular    potentially    confirmed    physiopathology    gene    basis    cell    devastating    age    onset    therapeutic    propensity    aetiology    understand    female    predisposing    resource    fibromuscular    size    medium    renal    clinical    instrumental    data    triggered    total    unprecedented    atherosclerotic    mechanisms    arterial    cerebrovascular    coronary    explore    context    diagnosed    dissection    rosalind    90    structure    genetic    cvd    expression   

Project "ROSALIND" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

Cardiovascular disease (CVD) is under-diagnosed and under-investigated specifically in women. Clinical presentation of CVD is often different in women and the aetiology of some diseases is potentially triggered by specific female sex environmental factors (e.g hormonal cycles and pregnancy) and could result in a distinct physiopathology from men. This may apply to fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection (SCAD), two devastating arterial diseases that share clinical features, which are non-atherosclerotic stenosis of medium-size arteries (renal and/or cerebrovascular arteries in FMD, coronary artery in SCAD) and an age of onset under 50, in addition to a high proportion of female patients (75-90%). In addition, genetic predisposing factors may interact with the female specific context and disturb the artery structure and/or function resulting in a female specific propensity to these CVDs. The ROSALIND project aims to: 1) Decipher the genetic basis of FMD and SCAD using genome-wide association in case control cohorts; 2) Examine the functional significance of the genetic susceptibility variants at confirmed loci and their targeted genes using high throughput NGS-based genomic methods and 3) explore the link of genes in FMD susceptibility loci with vascular function by the analyses of engineered cell lines and total expression in human renal arteries. This project will provide an unprecedented resource of genetic, gene expression and functional genomics data that will be instrumental to guide the uncovering of new genes and mechanisms involved in FMD and SCAD. This project will help better understand the physiopathology and shed light on novel and promising therapeutic targets for the non-atherosclerotic arterial stenosis that characterize these female CVDs

 Publications

year authors and title journal last update
List of publications.
2019 Angela H.E.M. Maas, Nabila Bouatia-Naji, Alexandre Persu, David Adlam
Spontaneous coronary artery dissections and fibromuscular dysplasia: Current insights on pathophysiology, sex and gender
published pages: 220-225, ISSN: 0167-5273, DOI: 10.1016/j.ijcard.2018.11.023
International Journal of Cardiology 286 2019-10-29
2019 Adrien Georges, Nabila Bouatia-Naji
La génétique établit le lien entre plusieurs maladies cardiovasculaires affectant préférentiellement les femmes
published pages: 605-607, ISSN: 0767-0974, DOI: 10.1051/medsci/2019119
médecine/sciences 35/8-9 2019-10-29
2019 David Adlam, Timothy M. Olson, Nicolas Combaret, Jason C. Kovacic, Siiri E. Iismaa, Abtehale Al-Hussaini, Megan M. O\'Byrne, Sara Bouajila, Adrien Georges, Ketan Mishra, Peter S. Braund, Valentina d’Escamard, Siying Huang, Marios Margaritis, Christopher P. Nelson, Mariza de Andrade, Daniella Kadian-Dodov, Catherine A. Welch, Stephani Mazurkiewicz, Xavier Jeunemaitre, Claire Mei Yi Wong, Eleni Gia
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection
published pages: 58-66, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2018.09.085
Journal of the American College of Cardiology 73/1 2019-10-29

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The information about "ROSALIND" are provided by the European Opendata Portal: CORDIS opendata.

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