Explore the words cloud of the EPI-Centrd project. It provides you a very rough idea of what is the project "EPI-Centrd" about.
The following table provides information about the project.
UNIVERSITE D'AIX MARSEILLE
|Coordinator Country||France [FR]|
|Total cost||1˙636˙250 €|
|EC max contribution||1˙636˙250 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||UNIVERSITE D'AIX MARSEILLE||FR (Marseille)||coordinator||1˙636˙250.00|
Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology. The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky. The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detection and the molecular delivery capability of the OEIP for seizure intervention. The devices will be a closed-loop system to detect seizure onset and intervene in the affected brain region.
|year||authors and title||journal||last update|
Mary J. Donahue, Attila Kaszas, Gergely F. Turi, BalÃ¡zs RÃ³zsa, Andrea SlÃ©zia, Ivo Vanzetta, Gergely Katona, Christophe Bernard, George G. Malliaras, Adam Williamson
Multimodal Characterization of Neural Networks Using Highly Transparent Electrode Arrays
published pages: ENEURO.0187-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0187-18.2018
Christopher M. Proctor, Ilke Uguz, Andrea Slezia, Vincenzo Curto, Sahika Inal, Adam Williamson, George G. Malliaras
An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
published pages: 1800270, ISSN: 2366-7478, DOI: 10.1002/adbi.201800270
|Advanced Biosystems 3/2||2020-01-27|
Andrea Slezia, Christopher M. Proctor, Attila Kaszas, George G. Malliaras, Adam Williamson
\"Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice\"
published pages: , ISSN: 1940-087X, DOI: 10.3791/59268
|Journal of Visualized Experiments 147||2019-10-17|
Jolien Pas, Alexandra L Rutz, Pascale P Quilichini, Andrea SlÃ©zia, Antoine Ghestem, Attila Kaszas, Mary J Donahue, Vincenzo F Curto, Rodney P Oâ€™Connor, Christophe Bernard, Adam Williamson, George G Malliaras
A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes
published pages: 65001, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aadc1d
|Journal of Neural Engineering 15/6||2019-04-18|
Mary J. Donahue, Adam Williamson, Xenofon Strakosas, Jacob T. Friedlein, Robert R. McLeod, Helena Gleskova, George G. Malliaras
High-Performance Vertical Organic Electrochemical Transistors
published pages: 1705031, ISSN: 0935-9648, DOI: 10.1002/adma.201705031
|Advanced Materials 30/5||2019-04-18|
Christopher M. Proctor, Andrea SlÃ©zia, Attila Kaszas, Antoine Ghestem, Isabel del Agua, Anna-Maria Pappa, Christophe Bernard, Adam Williamson, George G. Malliaras
Electrophoretic drug delivery for seizure control
published pages: eaau1291, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1291
|Science Advances 4/8||2019-04-18|
Amanda E. Hernan, Catherine A. Schevon, Gregory A. Worrell, Aristea S. Galanopoulou, Philippe Kahane, Marco de Curtis, Akio Ikeda, Pascale Quilichini, Adam Williamson, Norberto Garcia-Cairasco, Rod C. Scott, Igor Timofeev
Methodological standards and functional correlates of depth inÂ vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE
published pages: 28-39, ISSN: 0013-9580, DOI: 10.1111/epi.13905
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