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Epilepsy Controlled with Electronic Neurotransmitter Delivery

Total Cost €


EC-Contrib. €






 EPI-Centrd project word cloud

Explore the words cloud of the EPI-Centrd project. It provides you a very rough idea of what is the project "EPI-Centrd" about.

therapeutic    neurological    demonstrated    deficits    oeip    combine    postoperative    quality    treatment    conceptual    healthy    impaired    epilepsy    regions    function    deemed    deleterious    invasive    significantly    last    option    ion    inhibitory    motor    epileptiform    film    electrodes    rate    memory    patient    demand    risky    core    electronic    minimally    surgically    pharmacology    model    create    detect    functions    disease    pumps    severe    neurosurgery    delivering    disorders    probes    gt    leave    intervene    solution    too    clinical    neurotransmitters    transfer    intervention    30    brain    implantation    region    thin    implants    persons    closed    recordings    many    had    loop    onset    integrate    additionally    seizure    blood    frequently    cross    capability    electronics    speech    toxic    untreatable    drug    fails    drugs    surgery    breakthrough    failed    flexible    tissue    detection    organic    designed    resistant    rigid    resective    treat    molecular    electrophysiological    standard    clinic    million    vivo    simply    barrier    efficient    vitro    unacceptable    damage    resistance    oeips   

Project "EPI-Centrd" data sheet

The following table provides information about the project.


Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙636˙250 €
 EC max contribution 1˙636˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 1˙636˙250.00


 Project objective

Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology. The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky. The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detection and the molecular delivery capability of the OEIP for seizure intervention. The devices will be a closed-loop system to detect seizure onset and intervene in the affected brain region.


year authors and title journal last update
List of publications.
2018 Mary J. Donahue, Attila Kaszas, Gergely F. Turi, Balázs Rózsa, Andrea Slézia, Ivo Vanzetta, Gergely Katona, Christophe Bernard, George G. Malliaras, Adam Williamson
Multimodal Characterization of Neural Networks Using Highly Transparent Electrode Arrays
published pages: ENEURO.0187-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0187-18.2018
eneuro 5/6 2020-01-27
2019 Christopher M. Proctor, Ilke Uguz, Andrea Slezia, Vincenzo Curto, Sahika Inal, Adam Williamson, George G. Malliaras
An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
published pages: 1800270, ISSN: 2366-7478, DOI: 10.1002/adbi.201800270
Advanced Biosystems 3/2 2020-01-27
2019 Andrea Slezia, Christopher M. Proctor, Attila Kaszas, George G. Malliaras, Adam Williamson
\"Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice\"
published pages: , ISSN: 1940-087X, DOI: 10.3791/59268
Journal of Visualized Experiments 147 2019-10-17
2018 Jolien Pas, Alexandra L Rutz, Pascale P Quilichini, Andrea Slézia, Antoine Ghestem, Attila Kaszas, Mary J Donahue, Vincenzo F Curto, Rodney P O’Connor, Christophe Bernard, Adam Williamson, George G Malliaras
A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes
published pages: 65001, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aadc1d
Journal of Neural Engineering 15/6 2019-04-18
2018 Mary J. Donahue, Adam Williamson, Xenofon Strakosas, Jacob T. Friedlein, Robert R. McLeod, Helena Gleskova, George G. Malliaras
High-Performance Vertical Organic Electrochemical Transistors
published pages: 1705031, ISSN: 0935-9648, DOI: 10.1002/adma.201705031
Advanced Materials 30/5 2019-04-18
2018 Christopher M. Proctor, Andrea Slézia, Attila Kaszas, Antoine Ghestem, Isabel del Agua, Anna-Maria Pappa, Christophe Bernard, Adam Williamson, George G. Malliaras
Electrophoretic drug delivery for seizure control
published pages: eaau1291, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1291
Science Advances 4/8 2019-04-18
2017 Amanda E. Hernan, Catherine A. Schevon, Gregory A. Worrell, Aristea S. Galanopoulou, Philippe Kahane, Marco de Curtis, Akio Ikeda, Pascale Quilichini, Adam Williamson, Norberto Garcia-Cairasco, Rod C. Scott, Igor Timofeev
Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE
published pages: 28-39, ISSN: 0013-9580, DOI: 10.1111/epi.13905
Epilepsia 58 2019-04-18

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