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EPI-Centrd SIGNED

Epilepsy Controlled with Electronic Neurotransmitter Delivery

Total Cost €

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EC-Contrib. €

0

Partnership

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 EPI-Centrd project word cloud

Explore the words cloud of the EPI-Centrd project. It provides you a very rough idea of what is the project "EPI-Centrd" about.

film    electronics    pumps    impaired    blood    clinic    30    option    leave    simply    drugs    designed    unacceptable    fails    treatment    treat    organic    disorders    deficits    neurological    last    rigid    memory    many    pharmacology    loop    breakthrough    failed    epileptiform    intervene    solution    intervention    vitro    epilepsy    barrier    demand    neurosurgery    additionally    flexible    significantly    region    model    too    resective    untreatable    frequently    create    electronic    recordings    core    oeip    deemed    drug    conceptual    integrate    rate    brain    capability    detect    combine    resistance    function    electrophysiological    onset    damage    neurotransmitters    postoperative    patient    implants    severe    electrodes    speech    vivo    risky    implantation    surgically    delivering    had    surgery    gt    probes    thin    transfer    resistant    functions    tissue    seizure    ion    motor    quality    deleterious    clinical    molecular    inhibitory    oeips    cross    minimally    healthy    demonstrated    million    efficient    closed    therapeutic    invasive    regions    detection    toxic    disease    persons    standard   

Project "EPI-Centrd" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE D'AIX MARSEILLE 

Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙636˙250 €
 EC max contribution 1˙636˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 1˙636˙250.00

Map

 Project objective

Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology. The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky. The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detection and the molecular delivery capability of the OEIP for seizure intervention. The devices will be a closed-loop system to detect seizure onset and intervene in the affected brain region.

 Publications

year authors and title journal last update
List of publications.
2018 Mary J. Donahue, Attila Kaszas, Gergely F. Turi, Balázs Rózsa, Andrea Slézia, Ivo Vanzetta, Gergely Katona, Christophe Bernard, George G. Malliaras, Adam Williamson
Multimodal Characterization of Neural Networks Using Highly Transparent Electrode Arrays
published pages: ENEURO.0187-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0187-18.2018
eneuro 5/6 2020-01-27
2019 Christopher M. Proctor, Ilke Uguz, Andrea Slezia, Vincenzo Curto, Sahika Inal, Adam Williamson, George G. Malliaras
An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
published pages: 1800270, ISSN: 2366-7478, DOI: 10.1002/adbi.201800270
Advanced Biosystems 3/2 2020-01-27
2019 Andrea Slezia, Christopher M. Proctor, Attila Kaszas, George G. Malliaras, Adam Williamson
\"Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice\"
published pages: , ISSN: 1940-087X, DOI: 10.3791/59268
Journal of Visualized Experiments 147 2019-10-17
2018 Jolien Pas, Alexandra L Rutz, Pascale P Quilichini, Andrea Slézia, Antoine Ghestem, Attila Kaszas, Mary J Donahue, Vincenzo F Curto, Rodney P O’Connor, Christophe Bernard, Adam Williamson, George G Malliaras
A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes
published pages: 65001, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aadc1d
Journal of Neural Engineering 15/6 2019-04-18
2018 Mary J. Donahue, Adam Williamson, Xenofon Strakosas, Jacob T. Friedlein, Robert R. McLeod, Helena Gleskova, George G. Malliaras
High-Performance Vertical Organic Electrochemical Transistors
published pages: 1705031, ISSN: 0935-9648, DOI: 10.1002/adma.201705031
Advanced Materials 30/5 2019-04-18
2018 Christopher M. Proctor, Andrea Slézia, Attila Kaszas, Antoine Ghestem, Isabel del Agua, Anna-Maria Pappa, Christophe Bernard, Adam Williamson, George G. Malliaras
Electrophoretic drug delivery for seizure control
published pages: eaau1291, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1291
Science Advances 4/8 2019-04-18
2017 Amanda E. Hernan, Catherine A. Schevon, Gregory A. Worrell, Aristea S. Galanopoulou, Philippe Kahane, Marco de Curtis, Akio Ikeda, Pascale Quilichini, Adam Williamson, Norberto Garcia-Cairasco, Rod C. Scott, Igor Timofeev
Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE
published pages: 28-39, ISSN: 0013-9580, DOI: 10.1111/epi.13905
Epilepsia 58 2019-04-18

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