Opendata, web and dolomites

EPI-Centrd SIGNED

Epilepsy Controlled with Electronic Neurotransmitter Delivery

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EPI-Centrd project word cloud

Explore the words cloud of the EPI-Centrd project. It provides you a very rough idea of what is the project "EPI-Centrd" about.

intervene    million    inhibitory    efficient    organic    barrier    frequently    neurological    healthy    motor    blood    many    last    drug    oeip    minimally    standard    create    untreatable    surgically    cross    leave    epilepsy    unacceptable    model    gt    electronic    postoperative    impaired    molecular    pumps    seizure    onset    electrodes    disease    speech    demand    flexible    epileptiform    fails    additionally    significantly    thin    ion    rigid    regions    surgery    pharmacology    had    tissue    probes    invasive    memory    closed    option    rate    implantation    drugs    simply    function    persons    neurotransmitters    implants    transfer    functions    deficits    quality    neurosurgery    too    severe    damage    solution    electrophysiological    intervention    loop    brain    therapeutic    failed    capability    deemed    deleterious    film    detect    risky    patient    integrate    treat    delivering    clinical    recordings    resective    toxic    demonstrated    vivo    30    combine    vitro    resistance    disorders    core    resistant    conceptual    breakthrough    clinic    detection    region    designed    treatment    oeips    electronics   

Project "EPI-Centrd" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE D'AIX MARSEILLE 

Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙636˙250 €
 EC max contribution 1˙636˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 1˙636˙250.00

Map

 Project objective

Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology. The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky. The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detection and the molecular delivery capability of the OEIP for seizure intervention. The devices will be a closed-loop system to detect seizure onset and intervene in the affected brain region.

 Publications

year authors and title journal last update
List of publications.
2018 Mary J. Donahue, Attila Kaszas, Gergely F. Turi, Balázs Rózsa, Andrea Slézia, Ivo Vanzetta, Gergely Katona, Christophe Bernard, George G. Malliaras, Adam Williamson
Multimodal Characterization of Neural Networks Using Highly Transparent Electrode Arrays
published pages: ENEURO.0187-18.2, ISSN: 2373-2822, DOI: 10.1523/eneuro.0187-18.2018
eneuro 5/6 2020-01-27
2019 Christopher M. Proctor, Ilke Uguz, Andrea Slezia, Vincenzo Curto, Sahika Inal, Adam Williamson, George G. Malliaras
An Electrocorticography Device with an Integrated Microfluidic Ion Pump for Simultaneous Neural Recording and Electrophoretic Drug Delivery In Vivo
published pages: 1800270, ISSN: 2366-7478, DOI: 10.1002/adbi.201800270
Advanced Biosystems 3/2 2020-01-27
2019 Andrea Slezia, Christopher M. Proctor, Attila Kaszas, George G. Malliaras, Adam Williamson
\"Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice\"
published pages: , ISSN: 1940-087X, DOI: 10.3791/59268
Journal of Visualized Experiments 147 2019-10-17
2018 Jolien Pas, Alexandra L Rutz, Pascale P Quilichini, Andrea Slézia, Antoine Ghestem, Attila Kaszas, Mary J Donahue, Vincenzo F Curto, Rodney P O’Connor, Christophe Bernard, Adam Williamson, George G Malliaras
A bilayered PVA/PLGA-bioresorbable shuttle to improve the implantation of flexible neural probes
published pages: 65001, ISSN: 1741-2560, DOI: 10.1088/1741-2552/aadc1d
Journal of Neural Engineering 15/6 2019-04-18
2018 Mary J. Donahue, Adam Williamson, Xenofon Strakosas, Jacob T. Friedlein, Robert R. McLeod, Helena Gleskova, George G. Malliaras
High-Performance Vertical Organic Electrochemical Transistors
published pages: 1705031, ISSN: 0935-9648, DOI: 10.1002/adma.201705031
Advanced Materials 30/5 2019-04-18
2018 Christopher M. Proctor, Andrea Slézia, Attila Kaszas, Antoine Ghestem, Isabel del Agua, Anna-Maria Pappa, Christophe Bernard, Adam Williamson, George G. Malliaras
Electrophoretic drug delivery for seizure control
published pages: eaau1291, ISSN: 2375-2548, DOI: 10.1126/sciadv.aau1291
Science Advances 4/8 2019-04-18
2017 Amanda E. Hernan, Catherine A. Schevon, Gregory A. Worrell, Aristea S. Galanopoulou, Philippe Kahane, Marco de Curtis, Akio Ikeda, Pascale Quilichini, Adam Williamson, Norberto Garcia-Cairasco, Rod C. Scott, Igor Timofeev
Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE
published pages: 28-39, ISSN: 0013-9580, DOI: 10.1111/epi.13905
Epilepsia 58 2019-04-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPI-CENTRD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPI-CENTRD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

Cu4Peroxide (2020)

The electrochemical synthesis of hydrogen peroxide

Read More