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3D Scaffolds as a Stem Cell Delivery System for Musculoskeletal Regenerative Medicine

Total Cost €


EC-Contrib. €






Project "CELL HYBRIDGE" data sheet

The following table provides information about the project.


Organization address
address: Minderbroedersberg 4-6
postcode: 6200 MD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 1˙500˙000.00


 Project objective

Aging worldwide population demands new solutions to permanently restore damaged tissues, thus reducing healthcare costs. Regenerative medicine offers alternative therapies for tissue repair. Although first clinical trials revealed excellent initial response after implantation of these engineered tissues, long-term follow-ups demonstrated that degeneration and lack of integration with the surrounding tissues occur. Causes are related to insufficient cell-material interactions and loss of cell potency when cultured in two-dimensional substrates, among others. Stem cells are a promising alternative due to their differentiation potential into multiple lineages. Yet, better control over cell-material interactions is necessary to maintain tissue engineered constructs in time. It is crucial to control stem cell quiescence, proliferation and differentiation in three-dimensional scaffolds while maintaining cells viable in situ. Stem cell activity is controlled by a complex cascade of signals called “niche”, where the extra-cellular matrix (ECM) surrounding the cells play a major role. Designing scaffolds inspired by this cellular niche and its ECM may lead to engineered tissues with instructive properties characterized by enhanced homeostasis, stability and integration with the surrounding milieu. This research proposal aims at engineering constructs where scaffolds work as stem cell delivery systems actively controlling cell quiescence, proliferation, and differentiation. This challenge will be approached through a biomimetic design inspired by the mesenchymal stem cell niche. Three different scaffolds will be combined to achieve this purpose: (i) a scaffold designed to maintain cell quiescence; (ii) a scaffold designed to promote cell proliferation; and (iii) a scaffold designed to control cell differentiation. To prove the design criteria the evaluation of stem cell quiescence, proliferation, and differentiation will be assessed for musculoskeletal regenerative therapies.


year authors and title journal last update
List of publications.
2019 Sandra Camarero-Espinosa, Andrea Calore, Arnold Wilbers, Jules Harings, Lorenzo Moroni
Additive manufacturing of an elastic poly(ester)urethane for cartilage tissue engineering
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2019.11.041
Acta Biomaterialia 2019-12-16
2019 Honglin Chen, Danielle F. Baptista, Giuseppe Criscenti, João Crispim, Hugo Fernandes, Clemens van Blitterswijk, Roman Truckenmüller, Lorenzo Moroni
From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation
published pages: 14312-14321, ISSN: 2040-3364, DOI: 10.1039/c8nr10108f
Nanoscale 11/30 2019-12-16
2019 Jip Zonderland, Paul Wieringa, Lorenzo Moroni
A quantitative method to analyse F-actin distribution in cells
published pages: 2562-2569, ISSN: 2215-0161, DOI: 10.1016/j.mex.2019.10.018
MethodsX 6 2019-12-16
2017 Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B. Baker, Anne Leferink, Huipin Yuan, Roman Truckenmüller, Clemens van Blitterswijk, Lorenzo Moroni
Tailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineering
published pages: 82-93, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.07.003
Acta Biomaterialia 59 2019-05-27
2018 Honglin Chen, Xiaobin Huang, Minmin Zhang, Febriyani Damanik, Matthew B. Baker, Anne Leferink, Huipin Yuan, Roman Truckenmüller, Clemens van Blitterswijk, Lorenzo Moroni
Corrigendum to “Tailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineering” Acta Biomater. 59 (2017) 82–93
published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.01.030
Acta Biomaterialia 2019-05-27

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The information about "CELL HYBRIDGE" are provided by the European Opendata Portal: CORDIS opendata.

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