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Late Stage Fluorination and its Applications to Drug Discovery

Total Cost €


EC-Contrib. €






 FLUDD project word cloud

Explore the words cloud of the FLUDD project. It provides you a very rough idea of what is the project "FLUDD" about.

pharma    overcoming    tracers    accessible    met    modern    progressed    advantageous    molecules    disease    dosing    appreciation    scientific    groups    scanning    shorten    frequently    fragments    compliance    medicine    academia    healthcare    18f    stages    pet    therapeutics    proteins    synthesis    clinic    patient    tomography    therapies    chemical    small    scientists    emission    populate    educational    fluorine    times    pressing    literature    diagnostics    discovery    fludd    containing    led    radiochemical    profiles    drugs    fluorination    labeling    dependent    train    chemistry    later    engagement    alliance    stronger    progress    facilitated    efficacy    pharmacological    doctoral    industry    cycle    superior    isotope    augmented    positron    moved    biomolecules    commercial    emitting    entities    guide    techniques    all    century    safety    reduce    sources    links    generation    multidisciplinary    clinicians    stage    substituted    goalposts    oxford    benefits    preferred    candidate    pharmacokinetic    decision    drug    janssen    space   

Project "FLUDD" data sheet

The following table provides information about the project.


Organization address
city: OXFORD
postcode: OX1 2JD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 1˙341˙024 €
 EC max contribution 1˙341˙024 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    JANSSEN CILAG SA ES (Madrid) participant 247˙872.00


 Project objective

All of modern medicine is dependent on advances in chemistry and the healthcare goalposts have moved as the century has progressed. The pressing need to shorten cycle times and reduce the costs of drug discovery has led pharma and the clinicians that guide them to use scanning techniques such as positron emission tomography (PET), enabling them to increase disease understanding, study target engagement with therapeutics and improve decision making, so that only the best candidate molecules progress to the later stages of drug development. Overcoming these challenges requires multidisciplinary knowledge, and can be facilitated through stronger links between academia and Pharma. Chemical entities substituted with fluorine or fluorine-containing groups are frequently used to design drugs with improved pharmacological and pharmacokinetic profiles that provide important benefits over existing therapies, such as superior safety, efficacy, dosing, and patient compliance. Furthermore, 18F is often selected as the preferred positron-emitting isotope for the labeling of PET tracers due to its advantageous properties. The scientific objective of FLUDD is to develop novel late stage fluorination chemistry to populate the chemical and radiochemical space available for drug discovery with a focus on novel fluorine-containing fragments, molecules and biomolecules that are not directly accessible from commercial sources or the scientific literature. These novel methodologies will be applied to drugs and diagnostics discovery using both small molecules and proteins. The educational objective is to train the next generation of doctoral scientists in the practice of chemical synthesis and radiochemical methods with an in-depth appreciation of their applications in medicine. FLUDD objectives will be met with a novel Oxford-Janssen Alliance augmented with leading partners from academia, industry and the clinic.


List of deliverables.
Public Website, Press release, Outreach, Open days, Embassy Other 2019-06-06 16:17:26
Website and Newsletters Documents, reports 2019-06-06 16:17:24
FLUDD Schools Other 2019-06-06 16:17:26
ESR recruitment process Other 2019-06-06 16:17:22
Supervisory Board of the Network Documents, reports 2019-05-30 15:25:57

Take a look to the deliverables list in detail:  detailed list of FLUDD deliverables.


year authors and title journal last update
List of publications.
2019 Claudio F. Meyer, Sandrine M. Hell, Jeroen B.I. Sap, Antonio Misale, Aldo Peschiulli, Daniel Oehlrich, Andrés A. Trabanco, Véronique Gouverneur
Hydrochlorofluoromethylation of unactivated alkenes with chlorofluoroacetic acid
published pages: 130679, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.130679
Tetrahedron 8 October 2019 2019-11-08
2019 Claudio F. Meyer, Sandrine M. Hell, Antonio Misale, Andres A Trabanco, Veronique Gouverneur
Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201903801
Angewandte Chemie International Edition 2019-06-06

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The information about "FLUDD" are provided by the European Opendata Portal: CORDIS opendata.

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