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Microscopy - Making optimal use of photons and electrons

Total Cost €


EC-Contrib. €






 MicroMOUPE project word cloud

Explore the words cloud of the MicroMOUPE project. It provides you a very rough idea of what is the project "MicroMOUPE" about.

limited    specimen    temporal    signal    experiment    scattered    limit    creation    generator    accuracy    beam    university    shape    adaptive    tool    pulses    optical    microscopes    microscopy    sub    shot    proteins    specimens    resolution    plate    aberration    pattern    linear    tested    fast    nanoparticles    limits    arbitrary    pass    electro    vienna    feasible    potentials    dna    multiple    ponderomotive    coherent    electrons    interact    technologically    metal    sensitivity    optimal    proof    intense    modern    realized    optimize    cavities    optically    demonstrated    photons    fundamental    optics    times    electron    sensitive    bright    self    stanford    zernike    noise    single    blanking    detection    particle    evading    correction    spatial    nanometric    free    post    dark    overcoming    molecules    microscope    cells    introducing    landscapes    probe    of    laser    particles    designed    quadratic    interactions    created    enhancement    imaging    switch   

Project "MicroMOUPE" data sheet

The following table provides information about the project.


Organization address
city: WIEN
postcode: 1010

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 1˙672˙752 €
 EC max contribution 1˙672˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙672˙752.00


 Project objective

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

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The information about "MICROMOUPE" are provided by the European Opendata Portal: CORDIS opendata.

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