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MicroMOUPE SIGNED

Microscopy - Making optimal use of photons and electrons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MicroMOUPE project word cloud

Explore the words cloud of the MicroMOUPE project. It provides you a very rough idea of what is the project "MicroMOUPE" about.

realized    proteins    interactions    zernike    free    self    aberration    university    shot    nanometric    fast    metal    optically    electro    modern    limit    photons    interact    cavities    ponderomotive    pattern    created    arbitrary    nanoparticles    designed    tool    single    of    vienna    sensitive    correction    potentials    generator    resolution    optimize    spatial    optical    electron    linear    optics    times    signal    post    scattered    microscopes    quadratic    enhancement    technologically    fundamental    landscapes    electrons    specimen    intense    dark    temporal    experiment    optimal    microscopy    particles    limited    laser    coherent    evading    sensitivity    accuracy    proof    feasible    probe    shape    stanford    beam    specimens    limits    pass    demonstrated    switch    plate    creation    detection    microscope    introducing    molecules    cells    adaptive    tested    sub    pulses    particle    blanking    multiple    imaging    noise    dna    overcoming    bright   

Project "MicroMOUPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://imaging.univie.ac.at/
 Total cost 1˙672˙752 €
 EC max contribution 1˙672˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙672˙752.00

Map

 Project objective

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

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The information about "MICROMOUPE" are provided by the European Opendata Portal: CORDIS opendata.

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