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Microscopy - Making optimal use of photons and electrons

Total Cost €


EC-Contrib. €






 MicroMOUPE project word cloud

Explore the words cloud of the MicroMOUPE project. It provides you a very rough idea of what is the project "MicroMOUPE" about.

dna    metal    tested    detection    cells    bright    shot    correction    times    resolution    electron    post    noise    scattered    microscopy    nanoparticles    temporal    proof    pass    cavities    blanking    single    ponderomotive    proteins    stanford    laser    imaging    linear    signal    modern    molecules    photons    fast    optics    pulses    plate    electro    landscapes    optically    sensitivity    tool    designed    creation    beam    switch    nanometric    of    microscopes    generator    pattern    spatial    created    adaptive    interact    intense    realized    technologically    optical    vienna    limit    arbitrary    optimal    dark    introducing    shape    feasible    particle    quadratic    specimens    aberration    multiple    probe    sensitive    experiment    electrons    free    limits    self    potentials    accuracy    specimen    fundamental    coherent    limited    sub    microscope    zernike    optimize    interactions    particles    evading    overcoming    enhancement    university    demonstrated   

Project "MicroMOUPE" data sheet

The following table provides information about the project.


Organization address
city: WIEN
postcode: 1010

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 1˙672˙752 €
 EC max contribution 1˙672˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙672˙752.00


 Project objective

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

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The information about "MICROMOUPE" are provided by the European Opendata Portal: CORDIS opendata.

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