Opendata, web and dolomites


Reconstructing wiring rules of in vivo neural networks using simultaneous single-cell connectomics and transcriptomics

Total Cost €


EC-Contrib. €






 TYPEWIRE project word cloud

Explore the words cloud of the TYPEWIRE project. It provides you a very rough idea of what is the project "TYPEWIRE" about.

connectivity    repertoire    re    molecular    form    neurons    behaviours    organizational    functional    gene    thousands    space    tens    rnaseq    partial    principles    rules    functions    questions    single    relation    highlights    wiring    systematically    cellular    types    taxonomies    blocks    neuronal    topology    connections    resolve    implementations    unprecedented    brain    critical    conceivable    practically    diversity    reveal    obtain    cells    neural    neuroscience    connectomics    vivo    performs    unlimited    networks    purpose    fragmented    encode    orchestrated    conceptual    extraordinary    intelligence    network    vision    basic    expression    combine    assemble    datapoints    circuits    specialized    global    core    enormous    inspired    answering    transcriptome    cell    expand    function    synaptic    combinations    sophisticated    little    transcriptomics    computational    resolution    building    distinguish    picture    true    artificial    computation    systematic    nervous   

Project "TYPEWIRE" data sheet

The following table provides information about the project.


Organization address
city: HAIFA
postcode: 32000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙590˙000 €
 EC max contribution 1˙590˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The brain performs sophisticated functions and complex behaviours, orchestrated by highly specialized cells. Neurons are at the core of the nervous system’s computational capabilities. In recent years, we and others have advanced single-cell RNAseq to reveal their extraordinary molecular diversity in transcriptome-based cell-type taxonomies. It is the unique combinations of circuits that these different neuronal types form – within a practically unlimited space of possible implementations – that encode the large functional repertoire of the nervous system. Although critical, little is known about the basic organizational principles of cells within the circuits – the ‘wiring rules’. This highlights the conceptual challenge to measure connectivity on a systematic and synaptic, single-cell level. What is the topology of networks? What is the relation between network topology and function? How do cell types and gene expression determine wiring? Answering these questions will help resolve nervous system computation at the level of its cellular building blocks. The vision of this proposal is to provide and apply a novel approach that will allow us to investigate neuronal connectivity at large-scale. Two key requirements for such measurements are the ability to measure true synaptic connections, and obtain tens of thousands of datapoints. Further, the concept of cell types is crucial for addressing the connectivity problem, as it allows us to distinguish the network elements and thus assemble a global picture even from fragmented, partial measurements. For this purpose, we will combine transcriptomics and connectomics measurements at the single cell level. The proposed project has enormous potential to systematically (re)address basic functional questions in neuroscience. It can expand our understanding of neural circuits to an unprecedented resolution, with conceivable impact on computational research, such as in vivo inspired neural networks and artificial intelligence.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TYPEWIRE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TYPEWIRE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)


The Mass Politics of Disintegration

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More  
lastchecktime (2022-08-17 22:12:08) correctly updated